Continuously updated synthesis method about 155377-19-8

These common heterocyclic compound, 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7F3N2O2

Example 119: Preparation of l-(prop-2-yl)-3-trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester and 2-(prop-2-yl)-3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester3-Trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.2 mmol) was dissolved in acetonitrile (25 ml) and stirred at room temperature. To the solution was added 2-iodopropane (1.8 ml, 1.8 mmol), followed by potassium carbonate (2.488 g, 1.8 mmol). The reaction mixture was heated to reflux and stirred for 6.5 hours. The reaction mixture was stored at room temperature for 16 hours. The reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate and concentrated to give l-(prop-2-yl)-3- trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (isomer A) and 2-(prop-2-yl)- 3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester (isomer B) (9:1 mixture) as a yellow oil which was purified by column chromatography on silica gel (eluent: 0-10% ethyl acetate in hexane). Isomer A was obtained as a white solid (1.724 g, 57% yield). 1H-NMR (400 MHz, CDCl3): 1.35 (t, 3H, Me), 1.55 (d, 6H, Me), 4.3 (q, 2H, CH2), 4.55 (m, IH, CH), 8.0 (s, IH, CH) ppm.

The synthetic route of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.