Application of 29097-00-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29097-00-5 name is Methyl 3-amino-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1.0 g of compound (2′) is added to 10 ml of phosphoric acid to dissolve. This solution is ice-cooled to keep the temperature to -5 to 0C, and 0.54 g of sodium nitrite is added thereto, followed by stirring for 1 hour to obtain a diazonium salt solution. Separately, 20 ml of NMP (N- methylpyrrolidone) is added to 1.60 g of compound (3′) and, under stirring, the aforesaid diazonium salt solution is added thereto at 8C or lower. Simultaneously with completion of the addition, the ice bath is removed, and stirring is continued for further 1 hour. 40 ml of methanol is added to the reaction solution, and the resulting mixture is stirred for 30 minutes. Crystals precipitated are collected by filtration, and spray-washed with 30 ml of methanol. The thus- obtained crystals are added, without drying, to 100 ml of water, followed by stirring at 20 to 25C for 30 minutes. Crystals precipitated are collected by filtration, and sufficiently spray-washed with water. The thus-obtained crystals are added, without drying, to 20 ml of NMP and 10 ml of water, followed by stirring for 30 minutes under heating at 100C. After stirring for 30 minutes at room temperature, crystals precipitated are collected by filtration, and spray-washed with 20 ml of NMP/water=2/l and 20 ml of water. The thus-obtained crystals are dried to obtain 2.0 g of compound D-228 of the invention. Yield: 80%.Infrared absorption chart is shown in Fig. 6.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-amino-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.