Reference of 20154-03-4, A common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
From the indications on page 343 of Ref. refPreviewPlaceHolder49, the following procedure was designed: 3-(trifluoromethyl)-1H-pyrazolerefPreviewPlaceHolder [32] , refPreviewPlaceHolder33 M.E.F. Braibante, G. Clar, M.A.P. Martins and C. Jackson. J. Heterocycl. Chem., 30 (1993), pp. 1159-1160. [33] and refPreviewPlaceHolder[34] (1e) (5.54 g, 40.7 mol) and N-chlorosuccinimide (5.97 g, 44.7 mmol) in acetonitrile (13 mL) were heated in a microwave oven at 120 ¡ãC for 1 h. The resulting mixture was concentrated to dryness and dispersed in water (300 mL). The precipitate was filtered, rinsed with water and left to dry over 3 days to yield compound 3i (5.08 g, 73percent) as a powder; mp 94 ¡ãC 1H NMR (CDCl3): 7.69 (s, 1H); 11.2 (s (br), 1H). 13C NMR (CDCl3): 109.6; 120.2 (q, J=267 Hz); 129.5; 130.0 (q, J=37 Hz). HRMS: calcd for C4H2ClF3N2-H: 168.9780; Found: 168.9747.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.