326827-21-8, name is 3-Amino-5-cyclobutyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-Amino-5-cyclobutyl-1H-pyrazole
Example 271: Preparation of 6-((4-((5-cydobutyl-lH-pyrazol-3-yl)amino)-5- (trifluorometh l) rimidin-2-yl)amino)-3,4-dihydroquinoli -2(lH)-one.6-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(lH)-one (0.060 g, 0.175 mmol), 5-cyclobutyl-lH-pyrazol-3-amine (0.024 g, 0.175 mmol) and N-ethyl-N- isopropylpropan-2-amine (0.034 ml, 0.193 mmol) were mixed in DMF (2 ml). The mixture was microwaved at 130 C for 30 min and then concentrated. 14 mg of product was recovered after automated reverse phase chromatography (water- 10% THF in MeCN). MS calcd for[C2iH2oF3N70+H]+: 444.18 found 444.15.
The synthetic route of 326827-21-8 has been constantly updated, and we look forward to future research findings.