Adding a certain compound to certain chemical reactions, such as: 10199-68-5, name is 4-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10199-68-5, name: 4-Phenyl-1H-pyrazole
General procedure: To a solution of 4-aryl-1H-pyrazole or 1H-pyrazole (1.25 mmol) in dimethyl sulfoxide(DMSO) (1.5 mL), solid potassium tert-butoxide (1.38 mmol) was added, the mixture was stirred at room temperature for 15 min, then a solution of N-(2-(dimethylamino)ethyl)-4-bromonaphthalimide 2 (1.31 mmol) in DMSO (0.5 mL) was added through a syringe. The mixture washeated to 72 C and kept at this temperature for 1.5 h. Then the mixture was cooled to room temperature and quenched with ice water (10 mL), the precipitate was collected by filtration and oven-dried in vacuum. The crude pruduct was further purified by recrystallization from ethanol to give pure products 4a-4l in excellent yields.
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