Synthetic Route of 1128-54-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1128-54-7 as follows.
General procedure: A solution of equimolar amounts of 1b [1], 1c [16],d [17],e,f[17],g and 2,5-hexanedione 2 and p-toluenesulfonic acid monohydrate(20% mol/mol than the appropriate amine) in anhydrous dioxane was refluxed for different hours (see below). At set intervals of reflux (see below), 50% of stoichiometric amounts of 2,5-hexanedione was added. Then, the solvent was removed under reduced pressure and the oily residue was purified by flash chromatography and/or crystallization as described below.
According to the analysis of related databases, 1128-54-7, the application of this compound in the production field has become more and more popular.