Application of 2075-45-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2075-45-8 name is 4-Bromo-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2[00250j To solution of 4-bromo-1H-pyrazole (21.6 g, 147 mmol) in dichloromethane (400 mL) was added a solution of HC1 (4 N in dioxane) (2.204 mL, 8.82 mmol) and ethoxyethene (12.72 g, 176 mmol). After 30 mm, the reaction was quenched with aqueous NaHCO3 (30 mL), stirred at room temperature for lh, and the two layers were separated. The organic layer was washed with water, dried over Na2504, andconcentrated under reduced pressure to dryness to afford the crude product (28g). This material was purified by silica gel chromatography using a solvent gradient of EtOAc in hexanes to afford after concentration 13.2 g (4 1%) of the product as a clear oil. ?H NMR (400MHz, chloroform-d) oe 7.61 (s, 1H), 7.47 (s, 1H), 5.48 (q, J5.9 Hz, 1H), 3.53 – 3.41 (m, 1H),3.35(dq,J=9.5,7.OHz, 1H), 1.68- 1.62(m,3H), 1.21- 1.12(m,3H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.