71229-85-1, The chemical industry reduces the impact on the environment during synthesis 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.
To a degassed (N2 bubbling) solution of 4-bromo-1-ethyl-1H-pyrazole (2 g, 11.42 mmol) in 1,4-dioxane (30 ml) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-(1,3,2-dioxaborolane) (4.35 g, 17.14 mmol, 1.5 eq.), Pd(dppf)Cl2 (0.93 g, 1.14 mmol, 0.1 eq.) and potassium acetate (2.79 g, 28.55 mmol, 2.5 eq.) using the procedure of Intermediate Example 1(b). The solvent was distilled off to give the product in 88% yield (2.2 g). LC-MS (ESI): Calculated mass: 222.09; Observed mass: 223.3 [M+H]+ (rt: 0.83 min).
The chemical industry reduces the impact on the environment during synthesis 71229-85-1. I believe this compound will play a more active role in future production and life.