612511-81-6,Some common heterocyclic compound, 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the solution of 4-bromo-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl) methoxy)-2-methylpyridazin-3(2H)-one (73 mg, 0.2 mmol) in toluene (4 mL) underNz, (1-methyl-1Hpyrazol-3-yl)methanamine (22 mg, 0.2 mmol), Pd2(dba)3 (18 mg, 0.02 mmol), BINAP (18 mg,20 0.03 mmol) and Na01Bu (29 mg, 0.3 mmol) were added. After the reaction mixture was stirred at85 ¡ãC for 4 h, 15 mL water was added. The mixture was extracted with EtOAc (3 x 10 mL). Thecombined organics were dried over MgS04, filtered and concentrated in vacuo. The residue waspurified by Pre-HPLC to afford the title compound as a solid. 1H NMR (400 MHz, MeOD) o8.06 (d, 1H), 7.50(d, 1H), 7.30 (dd, 1H), 7.17 (d, 1H), 6.21 (d, 1H), 5.83 (s, 1H), 4.32 (s, 2H),25 4.18-4.14 (m, 1H), 4.06-4.02 (m, 1H), 3.87 (s, 3H), 3.84 (s, 3H), 3.62 (s, 3H), 2.09 -2.04 (m,1H), 1.76- 1.72(m, 1H), 1.20-1.15 (m, 1H), 1.05-1.00 (m, 1H); LRMS m/z (M+H) 397.2 found,3 97.19 required.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 612511-81-6, its application will become more common.