Ding, Yun’s team published research in ACS Combinatorial Science in 17 | CAS: 763120-58-7

ACS Combinatorial Science published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Product Details of C3H5BN2O2.

Ding, Yun published the artcileRobust Suzuki-Miyaura Cross-Coupling on DNA-Linked Substrates, Product Details of C3H5BN2O2, the publication is ACS Combinatorial Science (2015), 17(1), 1-4, database is CAplus and MEDLINE.

The Suzuki-Miyaura cross-coupling is one of the most widely employed reactions in medicinal chem. To apply this reaction to DNA-encoded library technol. (ELT), an alternative approach in the discovery of small mol. hits and leads, we explored the Suzuki-Miyaura cross-coupling on DNA-linked aryl halides. Pd(PPh3)4 was demonstrated to be an effective catalyst for cross-coupling with on-DNA halide substrates under aqueous conditions. It efficiently catalyzes the coupling of Ph halides (iodide or bromide) and pyridinyl bromides with various boronic acids/esters, including challenging heterocyclic boronic acids/esters.

ACS Combinatorial Science published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Product Details of C3H5BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics