Moriarty, R. M.’s team published research in Tetrahedron in 1989 | CAS: 27412-71-1

Tetrahedron published new progress about Oxidation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application of 5-Phenyl-1H-pyrazol-3(2H)-one.

Moriarty, R. M. published the artcileHypervalent iodine oxidation of 5-substituted and 4,5-disubstituted pyrazol-3(2H)-ones. A facile synthesis of methyl-2-alkynoates and methyl 2,3-alkadienoates, Application of 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrazolone oxidation iodine hypervalent; alkynoate methyl; alkadienoate methyl.

Hypervalent iodine oxidation of various 5-substituted pyrazol-3(2H)-ones I (R = Me, Et, CO2Me, CH2CO2Me, Ph, 4-ClC4H4, 4-MeC6H4, 4-MeOC6H4) with iodobenzene diacetate or iodosobenzene in methanol results in fragmentative loss of mol. dinitrogen to yield RCCCO2Me. However, 5-methyl-4-substituted pyrazol-3(2H)-ones II (R1 = Me, Et, CH2CO2Me, CH2Ph) under similar conditions yield Me 2,3-allenic esters H2C:C:CRCO2Me. Me 2,3-cycloalkadienoates III (n = 6, 7, 9) are obtained by the oxidative cleavage of 4,5-polymethylene pyrazol-3(2H)-ones IV using iodobenzene diacetate or iodosobenzene in methanol. The scope and mechanism of these reactions are discussed.

Tetrahedron published new progress about Oxidation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application of 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics