Guillou, Sandrine published the artcile5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities, Application In Synthesis of 27412-71-1, the main research area is substituted pyrazole preparation; arylation; heterocycles; organic synthesis; palladium; pyrazoles.
Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of Et 3-ethoxy-1H-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and di-Et 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole. These compounds have opened the way to a quick access to many original pyrazole series. As an illustration, we report here on the selectivity of N-arylation, by using the Lam and Cham method, the C4- and C5-arylation of some of these 3-ethoxypyrazole derivatives by using the Suzuki-Miyaura reaction, and C5-benzylation reactions by means of the Negishi reaction. This was followed by hydrolysis of the ethoxy group, which led to the corresponding pyrazol-3-one derivatives As a conclusion of this work, we conducted an investigation into the regiochem. of the condensation between di-Et 2-(ethoxymethylene)malonate and the hydrochloride salts of Me, benzyl, or Ph hydrazine.
Chemistry – A European Journal published new progress about Arylation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics