Kolodyazhna, Tatiana I. published the artcileSome Aspects of 4H-Pyrans Synthesis Based on 4-Chloro-1-ethyl-1H-benzo[c][1,2]thiazine-3-carbaldehyde 2,2-dioxide: Antimicrobial Activity of the Compounds Synthesized, Quality Control of 27412-71-1, the main research area is sigma linked benzopyrazolopyranothiazine dioxide preparation antibacterial antifungal.
A three-component interaction of 4-chloro-1-ethyl-1H-benzo[c][1,2]thiazine-3-carbaldehyde 2,2-dioxide with malononitrile and enol nucleophiles of heterocyclic nature has been studied. Depending on the nature of an enol nucleophile this reaction can lead either to heterocyclic ensemble of σ-linked 4-chloro-1-ethyl-1H-benzo[c][1,2]thiazine 2,2-dioxide and 2-amino-4H-pyran rings or condensed tetracyclic derivatives containing a new heterocyclic core of 7,10-dihydro-5H-benzo[c]pyrazolo[4′,3′:5,6]pyrano[2,3-e][1,2]thiazine 6,6-dioxide. The same result was obtained in the case of two-component approach involving 2-((4-chloro-1-ethyl-2,2-dioxido-1H-benzo[c][1,2]thiazin-3-yl)methylene)malononitrile. The structure of the tetracyclic derivatives has been confirmed by 2D NMR experiments A plausible mechanism of the three-component interaction resulting in the two possible products has been proposed. The synthesized compounds were screened for in vitro antibacterial and antifungal activities.
ChemistrySelect published new progress about Antibacterial agents. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics