4522-35-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4522-35-4, name is 3-Iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 3-iodo-1H-pyrazole (1 g, 5.16 mmol) and p-TsOH (88 mg, 0.52 mmol) in DCM (15 mL) was added DHP (0.56 mL, 6.19 mmol) and stirred atr.t. for2 hr. The reaction mixture was washed with satd. NaHCO3 and brine, dried over anhy. Na2SO4 and concentrated. The residue was purified by flash chromatography (silica gel, 0 -. 10% EtOAcin PE) to give 3-iodo-1-(oxan-2-yl)-1H-pyrazole (1.4 g). LC-MS (m/z 279 (M¡ÂH).
The synthetic route of 3-Iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.