330792-70-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
[0319] A mixture of (E)-2-( 4-( dimethylamino )-2-oxobut-3-enyl)isoindoline-1 ,3-dione ( 600 mg,2.33 mmol) and 5-amino-3-(4-phenoxy phenyl)-IH-pyrazole-4-carbonitrile (642 mg, 2.33mmol) in 20 mL of HOAc was stirred and heated to 120 ¡ãC for 15 hr. The mixture wasconcentrated and suspended in 30 mL of solvent (PE/EA = 411). The mixture was filtered andthe solid was purified by pre-TLC (DCM/EA = 5011) to give 430 mg (40percent) of 7-((1,3-dioxoisoindolin-2-yl )methyl)-2-( 4-phenoxyphenyl )pyrazolo [ 1 ,5-a ]pyrimidine-3-carbonitrile as a solid. 1H NMR (400 MHz, DMSO-d6) 8 8.74 (d, J = 4.4 Hz, IH), 8.05 (d, J = 8.8 Hz, 2H),7.96-7.90 (m, IH), 7.88-7.85 (m, 2H), 7.50 (d, J = 4.4 Hz, IH), 7.46-7.37 (m, 2H), 7.21-7.09 (m,5H), 5.32 (s, 2H). MS (ESI) m/e [M+It 472.1.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.