Computed Properties of C9H9N3O2On September 8, 2016 ,《Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate》 was published in ACS Medicinal Chemistry Letters. The article was written by Evans, Catherine A.; Liu, Tao; Lescarbeau, Andre; Nair, Somarajan J.; Grenier, Louis; Pradeilles, Johan A.; Glenadel, Quentin; Tibbitts, Thomas; Rowley, Ann M.; DiNitto, Jonathan P.; Brophy, Erin E.; OHearn, Erin L.; Ali, Janid A.; Winkler, David G.; Goldstein, Stanley I.; OHearn, Patrick; Martin, Christian M.; Hoyt, Jennifer G.; Soglia, John R.; Cheung, Culver; Pink, Melissa M.; Proctor, Jennifer L.; Palombella, Vito J.; Tremblay, Martin R.; Castro, Alfredo C.. The article contains the following contents:
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo and is currently in Phase 1 clin. evaluation in subjects with advanced solid tumors. After reading the article, we found that the author used Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1Computed Properties of C9H9N3O2)
Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Computed Properties of C9H9N3O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics