Category: 1620075-73-1

Computed Properties of C9H9N3O2On September 8, 2016 ,《Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate》 was published in ACS Medicinal Chemistry Letters. The article was written by Evans, Catherine A.; Liu, Tao; Lescarbeau, Andre; Nair, Somarajan J.; Grenier, Louis; Pradeilles, Johan A.; Glenadel, Quentin; Tibbitts, Thomas; Rowley, Ann M.; DiNitto, Jonathan P.; Brophy, Erin E.; OHearn, Erin L.; Ali, Janid A.; Winkler, David G.; Goldstein, Stanley I.; OHearn, Patrick; Martin, Christian M.; Hoyt, Jennifer G.; Soglia, John R.; Cheung, Culver; Pink, Melissa M.; Proctor, Jennifer L.; Palombella, Vito J.; Tremblay, Martin R.; Castro, Alfredo C.. The article contains the following contents:

Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo and is currently in Phase 1 clin. evaluation in subjects with advanced solid tumors. After reading the article, we found that the author used Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1Computed Properties of C9H9N3O2)

Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Computed Properties of C9H9N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,European Journal of Organic Chemistry included an article by Belaroussi, Rabia; El Hakmaoui, Ahmed; Akssira, Mohamed; Guillaumet, Gerald; Routier, Sylvain. Electric Literature of C9H9N3O2. The article was titled 《Regioselective Synthesis of 2,4-Substituted Pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyrimidines through Sequential Pd-Catalyzed Arylation and SNAr Reactions》. The information in the text is summarized as follows:

The synthesis and regioselective functionalization of rare 2,4-disubstituted-pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyrimidine derivatives is reported. C-4 aminations were performed by chlorine nucleophilic substitution SNAr reactions, and their efficiencies were compared with those for direct one-pot amide C-O activation with bromotripyrrolidinophosphonium hexafluorophosphate (PyBroP) as a reagent. The latter method was used to perform palladium-catalyzed C-4 (het)arylation. Finally, two C-4 amino and aryl derivatives were prepared on a large scale and engaged in desulfurative Liebeskind-Srogl-type reactions under microwave irradiation to afford the envisioned compound library. Each step was optimized, and the results are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1Electric Literature of C9H9N3O2)

Methyl 2-aminopyrazolo[1,5-a]pyridine-3-carboxylate(cas: 1620075-73-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Electric Literature of C9H9N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics