Day: November 28, 2022

Willson, Timothy M. published the artcileBone targeted drugs. 2. Synthesis of estrogens with hydroxyapatite affinity, COA of Formula: C11H16N2O5, the publication is Bioorganic & Medicinal Chemistry Letters (1996), 6(9), 1047-1050, database is CAplus.

The utility of the bone targeting 4-carboxy-3-hydroxy-1,2pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Pyrazoles I (n = 1, 4) demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Orazbayeva, Dina published the artcileDetermination of transformation products of unsymmetrical dimethylhydrazine in water using vacuum-assisted headspace solid-phase microextraction, Application of 1-Methylpyrazole, the publication is Journal of Chromatography A (2018), 30-36, database is CAplus and MEDLINE.

A new, sensitive and simple method based on vacuum-assisted headspace solid-phase microextraction (Vac-HSSPME) followed by gas chromatog.-mass-spectrometry (GC-MS), is proposed for the quantification of rocket fuel unsym. dimethylhydrazine (UDMH) transformation products in water samples. The target transformation products were: pyrazine, 1-methyl-1H-pyrazole, N-nitrosodimethylamine, N,N-dimethylformamide, 1-methyl-1H-1,2,4-triazole, 1-methyl-imidazole and 1H-pyrazole. For these analytes and within shorter sampling times, Vac-HSSPME yielded detection limits (0.5-100 ng L^-1) 3-10 times lower than those reported for regular HSSPME. Vac-HSSPME sampling for 30 min at 50 °C yielded the best combination of analyte responses and their standard deviations (<15%). 1-Formyl-2,2-dimethylhydrazine and formamide were discarded because of the poor precision and accuracy when using Vac-HSSPME. The recoveries for the rest of the analytes ranged between 80 and 119%. The modified Mininert valve and Thermogreen septum could be used for automated extraction as it ensured stable analyte signals even after long waiting times (>24 h). Finally, multiple Vac-HSSME proved to be an efficient tool for controlling the matrix effect and quantifying UDMH transformation products.

Journal of Chromatography A published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Keyari, Charles M. published the artcileSynthesis of New Quinolinequinone Derivatives and Preliminary Exploration of their Cytotoxic Properties, Application of 1H-Pyrazole-4-boronic acid, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3806-3819, database is CAplus and MEDLINE.

A series of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were synthesized, characterized, and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor agents. The synthesis of lavendamycin analogs is illustrated. Metabolism studies demonstrated that 7-amino analogs were generally better substrates for NQO1 than 7-amido analogs, as were compounds with smaller heteroaromatic substituents at the C-2 position. Surprisingly, only two compounds, 7-acetamido-2-(8′-quinolinyl)quinoline-5,8-dione and 7-amino-2-(2-pyridinyl)quinoline-5,8-dione, showed selective cytotoxicity toward the NQO1-expressing MDA468-NQ16 breast cancer cells vs. the NQO1-null MDA468-WT cells. For all other compounds, NQO1 protected against quinoline-5,8-dione cytotoxicity. Compound I showed potent activity against human breast cancer cells expressing or not expressing NQO1, with resp. IC₅₀ values of 190 nM and 140 nM and a low NQO1-mediated reduction rate, which suggests that the mode of action of I differs from that of lavendamycin and involves an unidentified target(s).

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Application of 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Songsichan, T. published the artcileThiocyanation of Pyrazoles Using KSCN/K₂S₂O₈ Combination, Synthetic Route of 930-36-9, the publication is SynOpen (2018), 2(1), 0006-0016, database is CAplus.

A convenient and practical thiocyanation of pyrazoles employed a combination of KSCN and K₂S₂O₈ in DMSO (DMSO) was reported. The salient features of the present reaction included environmentally benign reagents, solvents and simple operation. The reaction showed wide functional group tolerance and gave moderate to excellent yields.

SynOpen published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C5H6BNO2, Synthetic Route of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Alvarez, Eva Maria published the artcileLate-Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α-Amino Alkyl Radicals, Application of 1-Methylpyrazole, the publication is Angewandte Chemie, International Edition (2021), 60(24), 13609-13613, database is CAplus and MEDLINE.

We report a late-stage heteroarylation of aryl sulfonium salts through activation with α-amino alkyl radicals in a mechanistically distinct approach from previously reported halogen-atom transfer (XAT). The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of heteroarenes. Furthermore, we demonstrate the applicability of this methodol. in synthetically useful cross-coupling transformations.

Angewandte Chemie, International Edition published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, Alexander Nikolaevich published the artcileSynergistic solvent extraction of lanthanides(III) with mixtures of 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone and phosphoryl-containing podands, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Chimica Slovenica (2020), 67(1), 246-252, database is CAplus and MEDLINE.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu from weak acidic chloride solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone (HP) and phosphoryl-containing podands (L) has been studied. A considerable synergistic effect was observed in the presence of neutral ligands L in the organic phase containing HP. The stoichiometry of the Ln(III) extracted species was determined by slope anal. and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted with mixtures of HP and neutral ligands in toluene from weak acidic solutions as LnLP3 complexes.

Acta Chimica Slovenica published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, Alexander N. published the artcileAdsorption of lanthanides and scandium ions by silica sol-gel material doped with novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoyl-5-onate, Computed Properties of 4551-69-3, the publication is Journal of Environmental Chemical Engineering (2016), 4(4_Part_A), 3788-3796, database is CAplus.

Sol-gel processed silica doped with a novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoylpyrazol-5-onate ([A336]⁺[L]^–), was prepared and used as a sorbent for recovery and separation of scandium and lanthanides from nitric acid solutions The effect of HNO₃ concentration in the aqueous phase on the adsorption of microquantities of Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu is considered. A significant synergistic effect was observed for scandium and lanthanide adsorption from aqueous solutions Sc(III) is sorbed from aqueous solutions much better than lanthanides(III) and separation of Sc(III) from lanthanides(III) can be achieved by simple adjusting acidity of the aqueous phase. The efficiency of lanthanide(III) adsorption from low-concentration HNO₃ solutions increases with an increasing at. number The process of lanthanide(III) adsorption is exothermic, spontaneous and follows a pseudo-second-order kinetic model. The potentialities of the doped silica material for the preconcentration of lanthanides(III) and Sc(III) from nitrate solutions are demonstrated.

Journal of Environmental Chemical Engineering published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-Phosphorylphenoxyacetamides, Computed Properties of 4551-69-3, the publication is Russian Journal of Inorganic Chemistry (2019), 64(3), 407-413, database is CAplus.

Extraction of rare earth element(III) (REE) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-phosphorylphenoxyacetamides in organic solvents has been studied. Observed considerable synergic effect is related to the formation of hydrophobic mixed-ligand REE(III) complexes. The stoichiometry of extracted complexes has been determined and extraction constants have been calculated Effect of aqueous phase composition, organic solvent nature, and 2-phosphorylphenoxyacetamide structure on the efficiency of REE(III) ions recovery into organic phase has been considered.

Russian Journal of Inorganic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare-Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and Phosphoryl-Containing Podands, Formula: C17H14N2O2, the publication is Russian Journal of General Chemistry (2019), 89(9), 1830-1835, database is CAplus.

Extraction of rare-earth elements(III) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and phosphoryl-containing podands in organic solvents has been studied. The observed significant synergistic effect is associated with the formation of hydrophobic mixed-ligand complexes of rare-earth elements(III). The stoichiometry of the extracted complexes has been determined, and the extraction constants have been calculated The influence of the phosphoryl-containing podand structure, the organic solvent nature, and the aqueous phase composition on the efficiency of the extraction of rare-earth element(III) ions into the organic phase has been considered.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of Some New Tridentate Carbamoylmethylphosphine Oxides and 4-Benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one from Hydrochloric Acid Solutions, Computed Properties of 4551-69-3, the publication is Russian Journal of General Chemistry (2021), 91(3), 383-388, database is CAplus.

Extraction of rare earths(III) from hydrochloric acid solutions with mixtures of new tridentate carbamoylmethylphosphine oxides Ph₂P(O)CH₂CON(R)CH₂CH₂P(O)Ph₂ (R = Me, Bu, Oct) and 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one in organic solvents has been studied. The observed strong synergistic effect has been attributed to the formation of hydrophobic mixed-ligand rare earth complexes in the organic phase. Stoichiometry of the extractable complexes has been determined, and extraction constants have been calculated The effect of organic solvent and composition of the aqueous phase on the extraction efficiency has been analyzed.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C19H15NO3, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics