Day: November 22, 2022

Reaction of diazoacetic ester with propargyl acetate was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Zhurnal Obshchei Khimii in 1975.Product Details of 61453-49-4 The following contents are mentioned in the article:

Cyclization of HCCCH2OAc and N2CHCO2Et in refluxing toluene gave the isomeric pyrazolecarboxylates I and II. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Product Details of 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Product Details of 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product class 1: pyrazoles was written by Stanovnik, B.;Svete, J.. And the article was included in Science of Synthesis in 2002.Synthetic Route of C18H16N2O2 The following contents are mentioned in the article:

A review. Methods for preparing pyrazoles are reviewed including cyclization, ring transformation, aromatization and substituent modifications. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Synthetic Route of C18H16N2O2).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C18H16N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of N-Methoxy-N-methyl-β-enaminoketoesters: New synthetic precursors for the regioselective synthesis of heterocyclic compounds. [Erratum to document cited in CA145:271693] was written by Persson, Tobias;Nielsen, John. And the article was included in Organic Letters in 2007.Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

In the Supporting Information section, on page S6, “1 M aq HC1 (5 mL)” should read “1 M aq HC1 (2 mL)”. A corrected Supporting Information file has been posted online. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of isomeric pyrazoles by the reaction of propargyl acetate with alkyl diazoacetates was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1976.HPLC of Formula: 61453-49-4 The following contents are mentioned in the article:

Isomeric pyrazoles I, II (R = Et, Me) were obtained by cyclization of HCCCH2OAc with N2CHCO2R. Hydrolysis of I, II (R = Et) led to the corresponding deacetylated esters. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4HPLC of Formula: 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cross coupling of bromo sydnones: development of a flexible route toward functionalized pyrazoles was written by Browne, Duncan L.;Taylor, John B.;Plant, Andrew;Harrity, Joseph P. A.. And the article was included in Journal of Organic Chemistry in 2009.Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

The application of a Suzuki cross coupling approach to a range of C-4 substituted sydnones from a 4-bromosydnone is described. Moreover, the potential of this approach to prepare a diverse range of pyrazoles is demonstrated. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles. [Erratum to document cited in CA141:207140] was written by Antilla, Jon C.;Baskin, Jeremy M.;Barder, Timothy E.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2004.Reference of 741717-60-2 The following contents are mentioned in the article:

On page 5578, an important reference describing the copper-catalyzed N-arylation of pyrazoles was left out of the manuscript: Cristau, H.-J., Cellier, P. P.; Spindler, J.-F.; Taillefer, M. Eur. J. Organic Chem. 2004, 695-709. This study involved multiple reactions and reactants, such as Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2Reference of 741717-60-2).

Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Reference of 741717-60-2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Thermolysis of 2-methoxy-2,3,5-triaryl-1,3,4-oxadiazolines in the presence of trapping reagents was written by Scherowsky, Guenther;Franke, Hermann. And the article was included in Tetrahedron Letters in 1974.HPLC of Formula: 17355-75-8 The following contents are mentioned in the article:

Trapping experiments with HCCCO2Et, di-Me 1,2,4,5-tetrazine – 3,6 – dicarboxylate, and 1,3 – diphenylisobenzofuran showed that the thermal elimination of p-RC6H4CO2Me from the title compounds I and II gave a carbene-nitrene intermediate. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8HPLC of Formula: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. HPLC of Formula: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reaction of hydrazonic halides and stabilized phosphorus ylides. Evidence for a two step mechanism was written by Dalla Croce, Piero. And the article was included in Annali di Chimica (Rome, Italy) in 1973.Formula: C18H16N2O2 The following contents are mentioned in the article:

The reaction of RCCl:NNHR1 (R = CO2Et, Ac, R1 = Ph, p-O2NC6H4, o-O2NC6H4) with Ph3P:CHCOR2 (R2 = Ph, Me, CO2Et, NMe2, OEt) gave the corresponding I in a 2 step reaction via R2COCH(P+Ph3)CR:NN-R1. R2COC(:PPh3)CR:NNHR1 was isolated in the reaction. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Formula: C18H16N2O2).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C18H16N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Coelenterands: a new class of metal-encapsulating ligands was written by Hartshorn, Chris M.;Steel, Peter J.. And the article was included in Angewandte Chemie, International Edition in English in 1996.Application In Synthesis of 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) The following contents are mentioned in the article:

Several salts of I were prepared and the crystal and mol. structures of I[ZnCl₄] were determined by x-ray crystallog. Also, II(PF₆)₂ and the encapsulating ligand were prepared This study involved multiple reactions and reactants, such as 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7Application In Synthesis of 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole)).

1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

1,3-Dipolar cycloaddition of ethyl diazoacetate to alkynes in the pores of zeolite NaY was written by Kobayashi, Keijiro;Igura, Yuta;Imachi, Shouhei;Masui, Yoichi;Onaka, Makoto. And the article was included in Chemistry Letters in 2007.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

Zeolite NaY promotes 1,3-dipolar cycloaddition of Et diazoacetate to alkynes having an electron-withdrawing group to afford the corresponding functionalized pyrazoles in high yields. The activation of the dipolarophile inside the pores of NaY is proposed based on the ¹³C MAS NMR anal. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics