Category: 178424-17-4

Willson, Timothy M.’s team published research in Bioorganic & Medicinal Chemistry Letters in 6 | CAS: 178424-17-4

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Willson, Timothy M. published the artcileBone targeted drugs. 2. Synthesis of estrogens with hydroxyapatite affinity, COA of Formula: C11H16N2O5, the publication is Bioorganic & Medicinal Chemistry Letters (1996), 6(9), 1047-1050, database is CAplus.

The utility of the bone targeting 4-carboxy-3-hydroxy-1,2pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Pyrazoles I (n = 1, 4) demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics