Day: November 22, 2022

Glycosides of pyrazole and condensed pyrazole heterocycles. II. Synthesis of pyrazolo-[3,4-b]pyridine glycosides was written by Korbukh, I. A.;Blanko, F. F.;Preobrazhenskaya, M. N.;Dorn, H.;Kondakova, N. G.;Sukhova, T. I.;Kostyuchenko, N. P.. And the article was included in Zhurnal Organicheskoi Khimii in 1973.Product Details of 49834-67-5 The following contents are mentioned in the article:

β-D-Ribofuranosylpyrazolo[3,4-b]pyridines (I; R1 = Cl, H2NNH, Me2N, H2N, MeS) were obtained by condensation of the appropriate pyrazolo[3,4-b]pyridines with acyl derivatives of saccharides, followed by deacylation and appropriate substitution reactions. Addnl. 1-β-D-glucopyranosyl-4-chloropyrazolo[3,4-b]pyridine was prepared This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Product Details of 49834-67-5).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 49834-67-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxo-phosphonates was written by Sun, Aixue;Ye, Jia-Hai;Yu, Haitao;Zhang, Wenchao;Wang, Xiaolong. And the article was included in Tetrahedron Letters in 2014.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles was developed by reacting of hydrazonoyl halides with β-oxo-phosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility was established. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of 1-isopropylamino-3-(pyrazolo[1,5-a]pyridyloxy)-2-propanols was written by Miki, Yasuyoshi;Tasaka, Junko;Uemura, Kyoko;Miyazeki, Kunihiro;Yamada, Jun. And the article was included in Heterocycles in 1996.Application of 141032-72-6 The following contents are mentioned in the article:

Treatment of the 4-hydroxypyrazolo[1,5-a]pyridine with glycidyl tosylate in the presence of base, followed by reaction with isopropylamine gave 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-4-yloxy)-2-propanol. In a similar manner, 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-6- and 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-3-yloxy)-2-propanol were also prepared This study involved multiple reactions and reactants, such as Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6Application of 141032-72-6).

Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application of 141032-72-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation was written by Chen, Miao-Miao;Shao, Ling-Yan;Lun, Li-Jun;Wu, Yu-Liang;Fu, Xiao-Pan;Ji, Ya-Fei. And the article was included in Chinese Chemical Letters in 2019.SDS of cas: 17355-75-8 The following contents are mentioned in the article:

The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-1H-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp²-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallog., and probably serves as an active species in the catalytic cycle. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8SDS of cas: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of N-Methoxy-N-methyl-β-enaminoketoesters: New Synthetic Precursors for the Regioselective Synthesis of Heterocyclic Compounds was written by Persson, Tobias;Nielsen, John. And the article was included in Organic Letters in 2006.COA of Formula: C18H16N2O2 The following contents are mentioned in the article:

Weinreb amides react with the lithium or sodium acetylide of Et propynoate in a hitherto unexplored acyl substitution-conjugate addition sequence to furnish (E)-N-methoxy-N-methyl-β-enaminoketoesters. This approach provides a diverse entry to densely functionalized heterocyclic compounds, including pyrazoles through regioselective cyclocondensations with hydrazines in a microwave-assisted reaction. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8COA of Formula: C18H16N2O2).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C18H16N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Behavior of the hetero ring in γ-phenyl-Δβ,γ-butenolide derivatives toward hydrazines. Acid rearrangement of 4-phenylhydrazono-2-phenyloxazolin-5-one was written by Mustafa, Ahmed;Khattab, Samir A.;Asker, Wafia. And the article was included in Canadian Journal of Chemistry in 1963.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

The substituted pyridazinones 3-phenyl- and 1,3-diphenyl-5-benzylidene-1,4,5,6-tetrahydropyridazin-6-one have been prepared from α-phenacylcinnamic acid hydrazide and α-phenacylcinnamic acid phenylhydrazone, resp. The dipyridazinone (I) was prepared from the dilactone (II). Rearrangement of 4-phenylhydrazono-2-phenyloxazolin-5-one (III) now has been found to proceed also in the presence of acidic reagents. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Poly(pyrazol-1-ylmethyl)benzenes: new multidentate ligands was written by Hartshorn, Chris M.;Steel, Peter J.. And the article was included in Australian Journal of Chemistry in 1995.Computed Properties of C21H24N6 The following contents are mentioned in the article:

Twelve new multidentate poly(pyrazol-1-ylmethyl)benzene ligands have been synthesized by phase-transfer catalyzed alkylations of pyrazoles with poly(bromomethyl)benzenes, and their ¹H and ¹³C NMR spectra have been fully assigned. X-Ray crystal structure determinations have been carried out on the tetrachloropalladate salt of the diprotonated form of 1,4-bis(3,5-dimethylpyrazol-1-ylmethyl)-2,3,5,6-tetramethylbenzene and on hexakis(pyrazol-1-ylmethyl)benzene. This study involved multiple reactions and reactants, such as 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7Computed Properties of C21H24N6).

1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C21H24N6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

1,3-Dipolar cycloadditions. XXXIII. Differences in the reactivity of substituted nitrilimines was written by Huisgen, Rolf;Adelsberger, Klaus;Aufderhaar, Ernst;Knupfer, Hans;Wallbillich, Guenter. And the article was included in Monatshefte fuer Chemie in 1967.Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

cf. CA 67: 99380s. Disubstituted nitrilimines (16), released from hydrazide halides with Et3N were compared in their ability to undergo cycloadditions with 12 dipolarophiles of various activities. Electron-attracting substituents on the nitrilimine C and N stabilized the ground state, reduced the 1,3-dipolar activity, and promoted the formation of tetrasubstituted 1,4-dihydro-1,2,4,5-tetrazines (I). At least 3 different reaction paths from hydrazide halides to 1,4-dihydrotetrazines were shown. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Origin of the High Affinity and Selectivity of Novel Receptors for NH₄⁺ over K⁺: Charged Hydrogen Bonds vs Cation-π Interaction was written by Oh, Kyung Seok;Lee, Chi-Wan;Choi, Hyuk Soon;Lee, Seok Jong;Kim, Kwang S.. And the article was included in Organic Letters in 2000.Related Products of 172606-26-7 The following contents are mentioned in the article:

Given the recent report of a novel pyrazole receptor exhibiting a high selectivity for NH₄⁺ over K⁺, it would be interesting to investigate the origin of this selectivity and affinity so that better receptors could be designed. On the basis of extensive theor. studies, we conclude that the origin arises from a subtle interplay of charged H-bonds and cation-π interactions. The approach employed herein would be very useful in the rational design of novel functional mol. systems. This study involved multiple reactions and reactants, such as 1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7Related Products of 172606-26-7).

1,1′,1”-((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1H-pyrazole) (cas: 172606-26-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Related Products of 172606-26-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Discovery and evaluation of Ca_v3.1-selective T-type calcium channel blockers was written by Bezencon, Olivier;Remen, Lubos;Richard, Sylvia;Roch, Catherine;Kessler, Melanie;Moon, Richard;Mawet, Jacques;Ertel, Eric A.;Pfeifer, Thomas;Capeleto, Bruno. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

The authors identified and characterized a series of pyrazole amides as potent, selective Ca_v3.1-blockers. This series culminated with the identification of pyrazole amides (I) and (II), with excellent potencies and/or selectivities toward the Ca_v3.2- and Ca_v3.3-channels. This compound displays poor DMPK properties, making its use difficult for in vivo applications. Nevertheless, this compound as well as analogous ones are well-suited for in vitro studies. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics