Category: 49834-67-5

Glycosides of pyrazole and condensed pyrazole heterocycles. II. Synthesis of pyrazolo-[3,4-b]pyridine glycosides was written by Korbukh, I. A.;Blanko, F. F.;Preobrazhenskaya, M. N.;Dorn, H.;Kondakova, N. G.;Sukhova, T. I.;Kostyuchenko, N. P.. And the article was included in Zhurnal Organicheskoi Khimii in 1973.Product Details of 49834-67-5 The following contents are mentioned in the article:

β-D-Ribofuranosylpyrazolo[3,4-b]pyridines (I; R1 = Cl, H2NNH, Me2N, H2N, MeS) were obtained by condensation of the appropriate pyrazolo[3,4-b]pyridines with acyl derivatives of saccharides, followed by deacylation and appropriate substitution reactions. Addnl. 1-β-D-glucopyranosyl-4-chloropyrazolo[3,4-b]pyridine was prepared This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Product Details of 49834-67-5).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 49834-67-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors was written by Schirok, Hartmut;Kast, Raimund;Figueroa-Perez, Santiago;Bennabi, Samir;Gnoth, Mark J.;Feurer, Achim;Heckroth, Heike;Thutewohl, Michael;Paulsen, Holger;Knorr, Andreas;Huetter, Joachim;Lobell, Mario;Muenter, Klaus;Geiss, Volker;Ehmke, Heimo;Lang, Dieter;Radtke, Martin;Mittendorf, Joachim;Stasch, Johannes-Peter. And the article was included in ChemMedChem in 2008.Electric Literature of C6H5N3O The following contents are mentioned in the article:

Rho kinase plays a pivotal role in several cellular processes such as vasoregulation, making it a suitable target for the treatment of hypertension and related disorders. We discovered a compound class of Rho kinase (ROCK) inhibitors containing a 7-azaindole hinge-binding scaffold tethered to an aminopyrimidine core. Herein we describe the structure-activity relationships elucidated through biochem. and functional assays. The introduction of suitable substituents at the 3-position of the bicyclic moiety led to an increase in activity, which was required to design compounds with favorable pharmacokinetic profile. Azaindole I was identified as a highly selective and orally available ROCK inhibitor able to cause a sustained blood pressure reduction in vivo. This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Electric Literature of C6H5N3O).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Electric Literature of C6H5N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Insights from Ab initio quantum chemical calculations into the preferred tautomeric forms and binding affinities to CDK2 of substituted pyrazolopyridines was written by Duca, Jose S.;Madison, Vincent S.. And the article was included in Biopolymers in 2005.Formula: C6H5N3O The following contents are mentioned in the article:

Ab initio calculations were employed to compute pKa values and tautomer properties of a series of substituted pyrazolopyridines. The results show that the neutral 1H tautomer predominates, but upon protonation this proton migrates to give the preferred charged [2H,7H] tautomer. The basicity of the pyrazolopyridines is correlated with the electron donating capability of the 4-substituent. Ab initio free energy calculations were also used to identify determinants of binding affinity for some recently published pyrazolopyridine inhibitors of CDK2. Hydrogen-bonding affinity may be one important component of binding strength. This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Formula: C6H5N3O).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Formula: C6H5N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

New xanthine oxidase inhibitors of the pyrazolo[3,4-d]pyrimidine and pyrazolo[3,4-b]pyridine class. II. Comparative evaluation of their effectiveness was written by Vartanyan, L. S.;Rashba, Yu. E.;Kazachenko, A. I.;Korbukh, I. A.;Bulychev, Yu. N.;Preobrazhenskaya, M. N.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1982.Reference of 49834-67-5 The following contents are mentioned in the article:

Thirty pyrazolo[3,4-d]pyrimidines I (R = H, CH₂NMe₂, N-methylpiperazinylmethyl, or piperidinylmethyl; R¹ = H, CH₂NEt₂, or N-methylpiperazinylmethyl; R² = H or Me) and II [R = H, CN, CH₂CN, C(NH₂):NOH, etc.; R¹ = SH, SMe, NHNH₂, etc.; R² = H, SH, or SMe] and 5 pyrazolo[3,4-b]pyridines III (R = H or OH; R¹ = H, OH, SH, Cl, or SMe) were tested for xanthine oxidase  [9002-17-9]-inhibiting activity. The kinetics of xanthine oxidase inhibition by I, II, and III was studied. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Reference of 49834-67-5).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Reference of 49834-67-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics