Day: November 21, 2022

Lu, Chunliang published the artcileRegioselective Bromination of Thieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one and Sequential Suzuki Couplings, Quality Control of 763120-58-7, the publication is Journal of Organic Chemistry (2017), 82(17), 9229-9234, database is CAplus and MEDLINE.

Regioselective bromination of 5-methylthieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one (I) at 2 or 9-position was achieved by modulating the basicity of the reaction conditions. An anion directed site-specific bromination mechanism was proposed. In addition, a one-pot bromination-Suzuki coupling protocol was developed for quick access of analogs at 9-position, II [Ar = Ph, C₆H₄F-4, C₆H₄Cl-4, C₆H₄(CF₃)-4, C₆H₄OMe-4, C₆H₄Me-3, C₆H₄Me-2, 1-methylpyrazin-4-yl, thien-2-yl, pyridin-3-yl].

Journal of Organic Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Quality Control of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Li-Xia published the artcileDirect sulfonylation of pyrazolones with sodium sulfinates catalyzed by TBAI in water, Related Products of pyrazoles-derivatives, the publication is Tetrahedron Letters (2018), 59(15), 1517-1520, database is CAplus.

An efficient sulfonylation reaction of pyrazolones with sodium sulfinates catalyzed by TBAI was established. A wide variety of valuable sulfonated pyrazolones were obtained in good to excellent yields using water as solvent.

Tetrahedron Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Rheault, Tara R. published the artcileHeteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties, Product Details of C3H5BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(15), 4587-4592, database is CAplus and MEDLINE.

Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors’ physiochem. and DMPK properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Product Details of C3H5BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Trivedi, Amit published the artcileFacile one-pot synthesis and antimycobacterial evaluation of pyrazolo[3,4-d]pyrimidines, Application In Synthesis of 14580-22-4, the publication is Archiv der Pharmazie (Weinheim, Germany) (2008), 341(7), 435-439, database is CAplus and MEDLINE.

The present article describes a facile one-pot synthesis of a series of eight pyrazolo[3,4-d]pyrimidines I (R = H, 2-Cl, 3-Cl, 4-Me, 3-SO₃H, 4-SO₃H, etc.) which were evaluated for their in-vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar-Blue susceptibility test and the activity expressed as the min. inhibitory concentration (MIC) in mg/mL. The compounds I (R = 2-Cl, 3-Cl, 4-Me) and II exhibited the best results (1.2 μg/mL) when compared with first-line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore, this class of compounds could be a good starting point to develop new lead compounds in the treatment of multidrug-resistant tuberculosis.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C7H8BFO2, Application In Synthesis of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Spink, Edward published the artcileStructure-Activity Relationship for the Oxadiazole Class of Antibiotics, Related Products of pyrazoles-derivatives, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1380-1389, database is CAplus and MEDLINE.

The structure-activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding protein. They impair cell-wall biosynthesis and exhibit activities against the Gram-pos. bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. Compound I was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. This antibiotic is bactericidal and is orally bioavailable in mice. This class of antibiotics holds great promise in recourse against infections by MRSA.

Journal of Medicinal Chemistry published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C4H10O2, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Remya, Chandran published the artcileNeuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation, Recommanded Product: (1H-Pyrazol-5-yl)boronic acid, the publication is Computational and Structural Biotechnology Journal (2021), 4517-4537, database is CAplus and MEDLINE.

An novel high affinity multi-target directed ligands (MTDLs) against AChE and NMDAR, with reduced hepatotoxicity, performed in-silico structure-based modifications on tacrine, chem. synthesis of the derivatives and in-vitro validation of their activities. Nineteen such derivatives I [R = H, methylcarbamoyl, hydrazinecarbonyl, ethoxycarbonyl; R¹ = 2-furanyl, 1-methylpyrazol-4-yl, 2-FC₆H₄, etc.] showed inhibition with IC₅₀ values in the range of 18.53 ± 2.09 – 184.09 ± 19.23 nM against AChE and 0.27 ± 0.05 – 38.84 ± 9.64μM against NMDAR. Some of the selected compounds protected rat primary cortical neurons from glutamate induced excitotoxicity. Two of the tacrine derived MTDLs, I [R = H, R¹ = 1-methylpyrazol-4-yl; R = H, R¹ = 2-FC₆H₄] exhibited in-vivo efficacy in rats by protecting against behavioral impairment induced by administration of the excitotoxic agent, monosodium glutamate. Addnl., several of these synthesized compounds also exhibited promising inhibitory activitiy against butyrylcholinesterase. MTDL-201 I [R = H, R¹ = 1-methylpyrazol-4-yl] was also devoid of hepatotoxicity in-vivo. Given the therapeutic potential of MTDLs in disease-modifying therapy, studies revealed several promising MTDLs among which I [R = H, R¹ = 1-methylpyrazol-4-yl] appeared to be a potential candidate for immediate preclin. evaluations.

Computational and Structural Biotechnology Journal published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Recommanded Product: (1H-Pyrazol-5-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Dorn, Helmut published the artcileElectrophilic substitution of 3(5)-aminopyrazole, HPLC of Formula: 3553-12-6, the publication is Justus Liebigs Annalen der Chemie (1967), 141-6, database is CAplus.

3(5)-Aminopyrazole (I) was halogenated to give 3(5)-amino-4-halopryazole. Acetylation of I yielded 3(5)-acetamidopyrazole (II), as shown by ir spectroscopy. II was nitrated to give 3(5)-acetamido-4-nitropyrazole, resp. The tautomerism of I and the site of the preferred electrophilic substitution are discussed based on the N.M.R. spectra.

Justus Liebigs Annalen der Chemie published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, HPLC of Formula: 3553-12-6.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Latha, Ganesapandian published the artcileNickel-catalyzed oxidative hydroxylation of arylboronic acid: Ni(HBTC)BPY MOF as an efficient and ligand-free catalyst to access phenolic motifs, SDS of cas: 763120-58-7, the publication is Catalysis Communications, database is CAplus.

A straightforward and mild oxidative ipso-hydroxylation of arylboronic acids was achieved using a simple and non-noble metal, nickel-based reusable heterogeneous catalyst Ni(HBTC)BPY MOF (HBTC = benzene-1,3,5-tricarboxylate, BPY = 4,4′-bipyridine) in the presence of benign hydrogen peroxide as an oxidant under ambient reaction condition. The Ni(HBTC)BPY MOF exhibited excellent catalytic activity towards the formation of phenols from diverse arylboronic acids within short time and was reused up to five times without any notable loss in its activity as well as shown high functional group tolerance even in the presence of sensitive functionalities and useful to achieve hydroxyl group in heterocycles.

Catalysis Communications published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, SDS of cas: 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Arriau, J. published the artcileStudy by semiempirical methods on theoretical chemistry in the pyrazolone series. IV. Substituted derivatives of 1-phenyl-3-methylpyrazol-5-one, HPLC of Formula: 14580-22-4, the publication is Tetrahedron (1972), 28(23), 5725-38, database is CAplus.

The electronic spectrum of 1-phenyl-3-methylpyrazol-5-one was calculated by the semiempirical MO methods of complete neglect of differential overlap, Pariser-Parr-Pople, and Hueckel-ω. At long wavelengths the Ph groups gave 2 relatively weak bands, the pyrazolone ring showed an intense transition, and another strong band, only observed exptl. in solvents such as n-heptane, occurred at short wavelengths. Substituents in the Ph group influenced the spectra according to their nature and position. The effect of solvent was estimated quant.

Tetrahedron published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, HPLC of Formula: 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Desai, Krunal G. published the artcileMicrowave enhanced heterocyclization: A convenient procedure for antimicrobial 1,5-benzothiazepine compounds, SDS of cas: 14580-22-4, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2007), 46B(7), 1179-1186, database is CAplus.

A series of 2,5-dihydro-4-[1-(2-chlorophenyl)-3-methyl-5-pyrazolylidenamino]-2-aryl-1,5 benzothiazepines I [R = Ph, 2-HOC₆H₄, 3-O₂NC₆H₄, 2-ClC₆H₄, 4-ClC₆H₄, 4-Me₂NC₆H₄, 4-MeOC₆H₃-3-OH, 3,4,5-(MeO)₃C₆H₂, 3-PhOC₆H₄, 4-MeOC₆H₄] was synthesized by an environmentally benign procedure, and they were evaluated for their antimicrobial activity. On microwave irradiation (MWI) under solvent-free conditions, neat reactants resulted in enhancement of yields and reaction rates. Structures of the synthesized compounds were elucidated on the basis of elemental anal. and spectra. The compounds showed moderate antibacterial and antifungal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, SDS of cas: 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics