Trivedi, Amit published the artcileFacile one-pot synthesis and antimycobacterial evaluation of pyrazolo[3,4-d]pyrimidines, Application In Synthesis of 14580-22-4, the publication is Archiv der Pharmazie (Weinheim, Germany) (2008), 341(7), 435-439, database is CAplus and MEDLINE.
The present article describes a facile one-pot synthesis of a series of eight pyrazolo[3,4-d]pyrimidines I (R = H, 2-Cl, 3-Cl, 4-Me, 3-SO3H, 4-SO3H, etc.) which were evaluated for their in-vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar-Blue susceptibility test and the activity expressed as the min. inhibitory concentration (MIC) in mg/mL. The compounds I (R = 2-Cl, 3-Cl, 4-Me) and II exhibited the best results (1.2 μg/mL) when compared with first-line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore, this class of compounds could be a good starting point to develop new lead compounds in the treatment of multidrug-resistant tuberculosis.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C7H8BFO2, Application In Synthesis of 14580-22-4.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics