Day: November 21, 2022

Trabanco, Andres A. published the artcileNew positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones, Recommanded Product: 1H-Pyrazole-4-boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(3), 971-976, database is CAplus and MEDLINE.

A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as pos. allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 (I) is described.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C12H6NNaO4, Recommanded Product: 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Girimanchanaika, Swamy Savvemala published the artcileInvestigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells, SDS of cas: 763120-58-7, the publication is International Journal of Molecular Sciences (2021), 22(20), 11002, database is CAplus and MEDLINE.

The design and development of a small mol. named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which specifically inhibited the phosphorylation of BAD at Ser99 in human carcinoma cells has been previously reported. Herein, the synthesis, characterization, and effect on cancer cell viability of NPB analogs, and the single-crystal X-ray crystallog. studies of an example compound (4r), which was grown via slow-solvent evaporation technique is reported. Screening for loss of viability in mammary carcinoma cells revealed that compounds such as 2[4(2,3-dichlorophenyl)piperazin-1-yl][naphthalen-1-yl]methylphenol (4e), 5[4(2,3-dichlorophenyl)piperazin-1-yl](2-hydroxyphenyl)methyluran-2-carbaldehyde (4f), 3[2-hydroxyphenyl][4(p-tolyl)piperazin-1-ylmethyl]benzaldehyde (4i), and NPB inhibited the viability of MCF-7 cells with IC₅₀ values of 5.90, 3.11, 7.68, and 6.5 μM, resp. The loss of cell viability was enhanced by the NPB analogs synthesized by adding newer rings such as naphthalene and furan-2-carbaldehyde in place of N-cyclopentyl-benzamide of NPB. Furthermore, these compounds decreased Ser99 phosphorylation of hBAD. Addnl. in silico d. functional theory calculations suggested possibilities for other analogs of NPB that may be more suitable for further development.

International Journal of Molecular Sciences published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, SDS of cas: 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Cox, Brian published the artcileEscaping from Flatland: Antimalarial Activity of sp³-Rich Bridged Pyrrolidine Derivatives, Name: 3-Isopropyl-1H-pyrazole-5-carboxylic acid, the publication is ACS Medicinal Chemistry Letters (2020), 11(12), 2497-2503, database is CAplus and MEDLINE.

Synthetic photochem. to generate novel sp3-rich scaffolds and report the design, synthesis, and biol. testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold was utilized . Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5μM range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.

ACS Medicinal Chemistry Letters published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Name: 3-Isopropyl-1H-pyrazole-5-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Hack, Daniel published the artcileAsymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis, Application In Synthesis of 14580-22-4, the publication is Angewandte Chemie, International Edition (2016), 55(5), 1797-1800, database is CAplus and MEDLINE.

A stereoselective one-pot synthesis of spiropyrazolones, e.g., I, through an organocatalytic asym. Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chem. and mechanistic experiments

Angewandte Chemie, International Edition published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Application In Synthesis of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

He, Yuanjun published the artcileSynthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors, Application of 1H-Pyrazole-4-boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(1), 161-164, database is CAplus and MEDLINE.

The design and synthesis of isoxazole I is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds II and III which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound I. Extensive SAR studies will be described as well as preliminary in vivo data of the two lead compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Application of 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

He, Yuanjun published the artcileSynthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors, Product Details of C3H5BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(1), 161-164, database is CAplus and MEDLINE.

The design and synthesis of isoxazole I is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds II and III which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound I. Extensive SAR studies will be described as well as preliminary in vivo data of the two lead compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Product Details of C3H5BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Trivedi, A. R. published the artcileA facile synthesis of pyrazolo[3,4-d]pyrimidines, Product Details of C10H9ClN2O, the publication is Indian Journal of Heterocyclic Chemistry (2008), 17(4), 385-386, database is CAplus.

A new series of the pyrazolo[3,4-d]pyrimidines were prepared by one-pot reaction of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde, 1-(aryl)-3-methyl-1H-pyrazol-5-(4H)-ones and thiourea. Compounds were evaluated for their antimicrobial activity. Some of the compounds showed interesting antimicrobial activity as compared to the standard drugs.

Indian Journal of Heterocyclic Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C8H5F3N4, Product Details of C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Tsai, Chen-Yen published the artcileRing-opening polymerization of cyclic esters initiated by zirconium, titanium and yttrium complexes, Product Details of C17H14N2O2, the publication is RSC Advances (2014), 4(28), 14527-14537, database is CAplus.

A series of dinuclear zirconium [(Lⁿ)Zr(OⁱPr)₂]₂[(μ-OⁱPr)₂] (1–3, n = 1-3) as well as mononuclear titanium [(L³)Ti(OⁱPr)₂] (4), yttrium [(L²)YCl] (5) and zirconium [(Lⁿ)Zr(OⁱPr)₂] (6, n = 4; 7, n = 5) salen-type complexes (Lⁿ = dianionic [ONNO]-tetradentate ancillary ligand) have been prepared and characterized. Dinuclear zirconium salen complexes [(Lⁿ)Zr(OⁱPr)₂]₂[(μ-OⁱPr)₂] (1–3) showed effective activity toward the ring opening polymerization of lactides and ε-caprolactone. However, mononuclear titanium, yttrium and zirconium complexes 4–7 are almost inactive for the ROP of L-lactide. Solvent-free bulk polymerization of L-lactide initiated by dinuclear zirconium complex 2 with a conversion > 90% can be achieved within 10 min, yielding high mol. weight polylactide with low polydispersity index. Kinetic studies reveal the ROP of L-lactide initiated by dinuclear zirconium complex 3 has a first-order dependency on [LA].

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H12F3NO5S, Product Details of C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Du, Hai-Tang published the artcileSynthesis of 5-chloro-3-methyl-1-phenyl-N-[4-(trifluoromethyl)phenyl]thioxomethyl]-1H-pyrazole-4-carboxamide and 5-chloro-3-methyl-1-phenyl-N-[2,6-dichloro-4-(trifluoromethyl)phenyl]thioxomethyl]-1H-pyrazole-4-carboxamide derivatives and determination of their activity as agrochemical fungicides, Synthetic Route of 14580-22-4, the publication is Youji Huaxue (2008), 28(2), 356-360, database is CAplus.

A series of the title compounds was prepared in order to search for pesticides with high biol. activity and low toxicity. Their structures were characterized by IR, ¹H NMR spectra and elemental anal. A preliminary bioassay indicated that some compounds had fungicidal activity.

Youji Huaxue published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Synthetic Route of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zeng, Shaogao published the artcileDiscovery of an Orally Active and Long-Acting DPP-IV Inhibitor through Property-Based Optimization with an in Silico Biotransformation Prediction Tool, Related Products of pyrazoles-derivatives, the publication is ChemMedChem (2020), 15(16), 1608-1617, database is CAplus and MEDLINE.

Long-acting dipeptidyl peptidase IV inhibitors have emerged as promising mols. for interventions for type 2 diabetes. Once weekly dosing brings greater patient compliance and more stable glycemic control. Starting from our previous highly potent compound with a thienoprimidine scaffold, which is unfortunately severely hit by hepatic biotransformation, a lead compound was rapidly generated by drawing on the experience of our previously discovered long-acting compounds with pyrrolopyrimidine scaffold. With the aid of an in silico biotransformation prediction tool, (R)-2-((2-(3-aminopiperidin-1-yl)-4-oxo-6-(pyridin-3-yl)thieno[3,2-d]pyrimidin-3(4H)-yl)methyl)-4-fluorobenzonitrile(I) was eventually generated and determined to have high potency, a fine pharmacokinetic profile, and a long-acting in vivo efficacy.

ChemMedChem published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C17H28ClNO3, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics