Month: November 2022

Turanov, Alexander Nikolaevich published the artcileSynergistic solvent extraction of lanthanides(III) with mixtures of 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone and phosphoryl-containing podands, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Chimica Slovenica (2020), 67(1), 246-252, database is CAplus and MEDLINE.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu from weak acidic chloride solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone (HP) and phosphoryl-containing podands (L) has been studied. A considerable synergistic effect was observed in the presence of neutral ligands L in the organic phase containing HP. The stoichiometry of the Ln(III) extracted species was determined by slope anal. and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted with mixtures of HP and neutral ligands in toluene from weak acidic solutions as LnLP3 complexes.

Acta Chimica Slovenica published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, Alexander N. published the artcileAdsorption of lanthanides and scandium ions by silica sol-gel material doped with novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoyl-5-onate, Computed Properties of 4551-69-3, the publication is Journal of Environmental Chemical Engineering (2016), 4(4_Part_A), 3788-3796, database is CAplus.

Sol-gel processed silica doped with a novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoylpyrazol-5-onate ([A336]⁺[L]^–), was prepared and used as a sorbent for recovery and separation of scandium and lanthanides from nitric acid solutions The effect of HNO₃ concentration in the aqueous phase on the adsorption of microquantities of Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu is considered. A significant synergistic effect was observed for scandium and lanthanide adsorption from aqueous solutions Sc(III) is sorbed from aqueous solutions much better than lanthanides(III) and separation of Sc(III) from lanthanides(III) can be achieved by simple adjusting acidity of the aqueous phase. The efficiency of lanthanide(III) adsorption from low-concentration HNO₃ solutions increases with an increasing at. number The process of lanthanide(III) adsorption is exothermic, spontaneous and follows a pseudo-second-order kinetic model. The potentialities of the doped silica material for the preconcentration of lanthanides(III) and Sc(III) from nitrate solutions are demonstrated.

Journal of Environmental Chemical Engineering published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-Phosphorylphenoxyacetamides, Computed Properties of 4551-69-3, the publication is Russian Journal of Inorganic Chemistry (2019), 64(3), 407-413, database is CAplus.

Extraction of rare earth element(III) (REE) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-phosphorylphenoxyacetamides in organic solvents has been studied. Observed considerable synergic effect is related to the formation of hydrophobic mixed-ligand REE(III) complexes. The stoichiometry of extracted complexes has been determined and extraction constants have been calculated Effect of aqueous phase composition, organic solvent nature, and 2-phosphorylphenoxyacetamide structure on the efficiency of REE(III) ions recovery into organic phase has been considered.

Russian Journal of Inorganic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare-Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and Phosphoryl-Containing Podands, Formula: C17H14N2O2, the publication is Russian Journal of General Chemistry (2019), 89(9), 1830-1835, database is CAplus.

Extraction of rare-earth elements(III) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and phosphoryl-containing podands in organic solvents has been studied. The observed significant synergistic effect is associated with the formation of hydrophobic mixed-ligand complexes of rare-earth elements(III). The stoichiometry of the extracted complexes has been determined, and the extraction constants have been calculated The influence of the phosphoryl-containing podand structure, the organic solvent nature, and the aqueous phase composition on the efficiency of the extraction of rare-earth element(III) ions into the organic phase has been considered.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of Some New Tridentate Carbamoylmethylphosphine Oxides and 4-Benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one from Hydrochloric Acid Solutions, Computed Properties of 4551-69-3, the publication is Russian Journal of General Chemistry (2021), 91(3), 383-388, database is CAplus.

Extraction of rare earths(III) from hydrochloric acid solutions with mixtures of new tridentate carbamoylmethylphosphine oxides Ph₂P(O)CH₂CON(R)CH₂CH₂P(O)Ph₂ (R = Me, Bu, Oct) and 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one in organic solvents has been studied. The observed strong synergistic effect has been attributed to the formation of hydrophobic mixed-ligand rare earth complexes in the organic phase. Stoichiometry of the extractable complexes has been determined, and extraction constants have been calculated The effect of organic solvent and composition of the aqueous phase on the extraction efficiency has been analyzed.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C19H15NO3, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileSynergistic Solvent Extraction of Lanthanides(III) with Mixtures of 4-benzoyl-3-methyl-1-phenylpyrazol-5-one and Some Novel Carbamoyl- and Phosphorylmethoxymethylphosphine Oxides, Application In Synthesis of 4551-69-3, the publication is Solvent Extraction and Ion Exchange (2014), 32(5), 492-507, database is CAplus.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y from weak acidic hydrochloric acid solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenylpyrazol-5-one (HP) and neutral tridentate organophosphorus ligands R₂P(O)CH₂OCH₂C(O)NBu₂ R = Bu (I), R = Ph (II) and R₂P(O)CH₂OCH₂P(O)R¹₂ R = R¹ = Bu (III); R = Bu, R¹ = Ph (IV); R = R¹ = Ph(V) has been studied. A considerable synergistic effect was observed in the presence of HP in the organic phase containing tetraoctyldiglycolamide (TODGA) and neutral organophosphorus ligands . A successive replacement of C(O)NAlk₂ groups in the diglycolamide extractant mol. by P(O)Ph₂ groups leads to an increase in the extraction efficiency of Ln(III) ions when toluene was used as diluent. Phosphoryl-containing podand possess a higher extraction efficiency towards Ln(III) ions than TODGA. The extraction equilibrium was investigated and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted as LnLP₃ and LnL₂P₃ complexes with mixtures of HP and I in toluene from weak acidic solutions

Solvent Extraction and Ion Exchange published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C3H5BN2O2, Application In Synthesis of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lin, Cai published the artcileExploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents, Category: pyrazoles-derivatives, the publication is European Journal of Medicinal Chemistry (2022), 114367, database is CAplus and MEDLINE.

Leishmaniasis causes high mortality and morbidity in tropical and subtropical regions of Africa, Asia, the Americas and southern Europe, and is characterized by diverse clin. manifestations. The Leishmania parasite is deficient in de novo purine synthesis, and therefore acquires purines from the host and processes these using a purine salvage pathway. In vitro screening of an inhouse purine nucleoside library and analog synthesis afforded the 6-methyl-7-(2-pyridyl)-7-deazapurine ribonucleoside analog, e.g. I, as a promising hit. Encouraged by the favorable in vitro metabolic stability, an in vivo study was performed using an early curative L. infantum hamster model. When orally administrated at 50 mg/kg once daily (s.i.d) for 10 days, I was devoid of side effects, however, it only poorly reduced amastigote burdens in the major target organs.

European Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Rizwan, Komal published the artcilePalladium catalyzed cross-coupling of 3-methylthiophene-2-carbonyl chloride with aryl/het-aryl boronic acids: a convenient method for synthesis of thienyl ketones, Synthetic Route of 724710-02-5, the publication is Journal of Sulfur Chemistry (2022), 43(5), 494-506, database is CAplus.

A protocol for the synthesis of thienyl ketones was developed via Pd(0) catalyzed cross-coupling reaction. The desired thienyl ketones were synthesized by cross coupling of 3-methylthiophene-2-carbonyl chloride with variety of aryl/heteroarylboronic acids in good to excellent yields (46-91%) under mild conditions (1.5 equiv Cs₂CO₃ at 50°C). Different functional groups were well tolerated under the developed reaction conditions.

Journal of Sulfur Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Synthetic Route of 724710-02-5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Purohit, Vishal B. published the artcilePalladium N-heterocyclic carbene catalyzed regioselective C-H halogenation of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones using N-halosuccinimides (NXS), Quality Control of 14580-22-4, the publication is Catalysis Science & Technology (2015), 5(6), 3113-3118, database is CAplus.

A novel palladium N-heterocyclic carbene [Pd(NHC)Cl₂] complex of vitamin B₁ was synthesized and characterized by ¹H NMR, EDX, FT-IR and UV-visible spectroscopy. The complex was used as a catalyst for regioselective ortho-C-H chlorination/bromination of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones via C-H bond activation utilizing Ag₂O as the effective terminal additive. The catalyst was easy to prepare, efficient and found to be highly regioselective, affording the target products in moderate to excellent yields.

Catalysis Science & Technology published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Quality Control of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Richman, Jeremy G. published the artcileNicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors, Synthetic Route of 890590-91-7, the publication is Journal of Biological Chemistry (2007), 282(25), 18028-18036, database is CAplus and MEDLINE.

Nicotinic acid remains the most effective therapeutic agent for the treatment and prevention of atherosclerosis resulting from low high d. lipoprotein cholesterol. The therapeutic actions of nicotinic acid are mediated by GPR109A, a G_i protein-coupled receptor, expressed primarily on adipocytes, Langerhans cells, and macrophage. Unfortunately, a severe, cutaneous flushing side effect limits its use and patient compliance. The mechanism of high d. lipoprotein elevation is not clearly established but assumed to be influenced by an inhibition of lipolysis in the adipose. The flushing side effect appears to be mediated by the release of prostaglandin D2 from Langerhans cells in the skin. We hypothesized that the signal transduction pathways mediating the anti-lipolytic and prostaglandin D2/flushing pathways are distinct and that agonists may be identified that are capable of selectively eliciting the therapeutic, anti-lipolytic pathway while avoiding the activation of the parallel flush-inducing pathway. We have identified a number of GPR109A pyrazole agonists that are capable of fully inhibiting lipolysis in vitro and in vivo and not only fail to elicit a flushing response but can antagonize the ability of nicotinic acid to elicit a flush response in vivo. In contrast to flushing agonists, exposure of cells expressing GPR109A to the non-flushing agonists fails to induce internalization of the receptor or to activate ERK 1/2 mitogen-activated protein kinase phosphorylation.

Journal of Biological Chemistry published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Synthetic Route of 890590-91-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics