Peterson, L. K.’s team published research in Canadian Journal of Chemistry in 52 | CAS: 53355-55-8

Canadian Journal of Chemistry published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Recommanded Product: 1H-Pyrazole-1-carbonyl chloride.

Peterson, L. K. published the artcileMechanism of the transition metal-catalyzed reaction of 1,1′-carbonyldipyrazoles with aldehydes and ketones, Recommanded Product: 1H-Pyrazole-1-carbonyl chloride, the publication is Canadian Journal of Chemistry (1974), 52(13), 2367-74, database is CAplus.

The metal-catalyzed reaction of 1,1′-carbonyldipyrazoles with aldehydes or ketones to give 1,1′-alkylidenedipyrazoles and CO2, the latter being derived from the amide carbonyl group as shown by labeling experiments, is sensitive to electronic and steric substituent effects. Under comparable reaction conditions, 1,1′-carbonyldiimidazole, N-acetylpyrazole, and 1-pyrazole-N,N-diethylcarbonamide do not react with acetone while pyrazole-1-carbo(N’-phenylhydrazide) yields an anilino isocyanate dimer. These results are interpreted in terms of a mechanism that involves coordination of the metal ion at the 2,2′-N atoms of the pyrazole rings and heterolytic cleavage of an amide bond, followed by formation of a carbamate intermediate, decarboxylation, and metal ion exchange. Unsym. substituted 1,1′-carbonyldipyrazoles equilibrate thermally with their resp. sym. analogs by an intermol. exchange mechanism.

Canadian Journal of Chemistry published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Recommanded Product: 1H-Pyrazole-1-carbonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Dehbi, Ouarda’s team published research in Acta Crystallographica, Section E: Structure Reports Online in 68 | CAS: 4551-69-3

Acta Crystallographica, Section E: Structure Reports Online published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Dehbi, Ouarda published the artcileBis(4-benzoyl-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-olato-κ2O,O’)(methanol-κO)dioxidouranium(VI) methanol monosolvate, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(4), m457-m458, database is CAplus and MEDLINE.

In the title compound, [U(C17H13N2O2)2O2(MeOH)]·MeOH, the UVI ion is coordinated by seven O atoms in a distorted pentagonal-bipyramidal geometry with two 3-methyl-1-phenyl-4-benzoyl-4,5-dihydro-1H-pyrazol-5-olate groups with two O atoms in a bidentate chelating coordination mode and by three O atoms, one of which is from a MeOH ligand. The crystal packing can be described by alternating layers of complex mols. along the a axis. The structure is stabilized by O-H···N and O-H···O H bonding and van der Waals interactions. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Mulyana, Yanyan’s team published research in Dalton Transactions in | CAS: 19959-71-8

Dalton Transactions published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Mulyana, Yanyan published the artcileNew cobalt(II) and zinc(II) coordination frameworks incorporating a pyridyl-pyrazole ditopic ligand, Category: pyrazoles-derivatives, the publication is Dalton Transactions (2005), 1598-1601, database is CAplus and MEDLINE.

The metal-directed assembly of new mol. frameworks incorporating 4-(4-pyridyl)pyrazole (HL), containing non-linear coordination vectors, is presented. Three metallo-arrays of types [Co(LH2)2(NO3)4], [Co(LH2)2(H2O)4][NO3]4·H2O and [Zn2(L)2Cl2]·2EtOH. The cobalt(II) in [Co(LH2)2(NO3)4] displays distorted octahedral geometry with the two protonated pyridylpyrazole ligands coordinated through their pyrazole nitrogen atoms in a trans-orientation and the remaining four coordination sites occupied by nitrate anions. Two internal hydrogen bonds occur between each pyrazole NH and the oxygens of adjacent coordinated nitrato ligands. Short intermol. hydrogen bonds also occur between the two pyridinium hydrogens and bound nitrate ligands on different mols. to yield a two-dimensional hydrogen-bonded array. Two of these arrays interpenetrate to form an extended two dimensional layer. The two-dimensional layers stack throughout the crystal structure. A second product of type [Co(LH2)2(H2O)4][NO3]4·H2O exists as two crystallog. independent forms that are chem. similar. In each form, the two protonated pyridylpyrazole ligands occupy trans positions about the cobalt with the remaining four coordination sites being filled by water mols. to yield a distorted octahedral coordination geometry. Intramol. hydrogen-bonding is observed between the two non-coordinated pyrazoyl nitrogen atoms and bound water oxygen atoms. The third complex, [Zn2(L)2Cl2]·2EtOH, contains dimer units consisting of two zinc(II) ions bridged by two pyrazoylate groups in which the coordination geometry of each zinc approximates a tetrahedron. Each zinc is bound to two deprotonated pyridylpyrazolato ligands, one pyridyl group (from a different dimeric unit) and one chloro ligand. Each pyridyl nitrogen thus connects each of these zinc dimers to an adjacent dimer unit, forming a three-dimensional network containing small voids. The latter are occupied by ethanol mols. which form hydrogen bonds to the chloro ligands.

Dalton Transactions published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Hong, Lin’s team published research in Journal of Biological Chemistry in 288 | CAS: 71203-35-5

Journal of Biological Chemistry published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, COA of Formula: C22H21N3O3S.

Hong, Lin published the artcileCharacterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe, COA of Formula: C22H21N3O3S, the publication is Journal of Biological Chemistry (2013), 288(12), 8531-8543, database is CAplus and MEDLINE.

Cdc42 plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathol. of cancers, immune diseases, and neuronal disorders. Therefore, Cdc42 inhibitors would be useful in probing mol. pathways and could have therapeutic potential. Previous inhibitors have lacked selectivity and trended toward toxicity. We report here the characterization of a Cdc42-selective guanine nucleotide binding lead inhibitor that was identified by high throughput screening. A second active analog was identified via structure-activity relationship studies. The compounds demonstrated excellent selectivity with no inhibition toward Rho and Rac in the same GTPase family. Biochem. characterization showed that the compounds act as noncompetitive allosteric inhibitors. When tested in cellular assays, the lead compound inhibited Cdc42-related filopodia formation and cell migration. The lead compound was also used to clarify the involvement of Cdc42 in the Sin Nombre virus internalization and the signaling pathway of integrin VLA-4. Together, these data present the characterization of a novel Cdc42-selective allosteric inhibitor and a related analog, the use of which will facilitate drug development targeting Cdc42-related diseases and mol. pathway studies that involve GTPases.

Journal of Biological Chemistry published new progress about 71203-35-5. 71203-35-5 belongs to pyrazoles-derivatives, auxiliary class GPCR/G Protein,Ras, name is 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C22H21N3O3S, COA of Formula: C22H21N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Waterson, Alex G.’s team published research in ACS Medicinal Chemistry Letters in 6 | CAS: 13599-22-9

ACS Medicinal Chemistry Letters published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C7H7BN2O2, Synthetic Route of 13599-22-9.

Waterson, Alex G. published the artcileDiphenylpyrazoles as replication protein A inhibitors, Synthetic Route of 13599-22-9, the publication is ACS Medicinal Chemistry Letters (2015), 6(2), 140-145, database is CAplus and MEDLINE.

Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here the authors describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. The authors evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.

ACS Medicinal Chemistry Letters published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C7H7BN2O2, Synthetic Route of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Willson, Timothy M.’s team published research in Bioorganic & Medicinal Chemistry Letters in 6 | CAS: 178424-17-4

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Willson, Timothy M. published the artcileBone targeted drugs. 2. Synthesis of estrogens with hydroxyapatite affinity, COA of Formula: C11H16N2O5, the publication is Bioorganic & Medicinal Chemistry Letters (1996), 6(9), 1047-1050, database is CAplus.

The utility of the bone targeting 4-carboxy-3-hydroxy-1,2pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Pyrazoles I (n = 1, 4) demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Orazbayeva, Dina’s team published research in Journal of Chromatography A in 1555 | CAS: 930-36-9

Journal of Chromatography A published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Orazbayeva, Dina published the artcileDetermination of transformation products of unsymmetrical dimethylhydrazine in water using vacuum-assisted headspace solid-phase microextraction, Application of 1-Methylpyrazole, the publication is Journal of Chromatography A (2018), 30-36, database is CAplus and MEDLINE.

A new, sensitive and simple method based on vacuum-assisted headspace solid-phase microextraction (Vac-HSSPME) followed by gas chromatog.-mass-spectrometry (GC-MS), is proposed for the quantification of rocket fuel unsym. dimethylhydrazine (UDMH) transformation products in water samples. The target transformation products were: pyrazine, 1-methyl-1H-pyrazole, N-nitrosodimethylamine, N,N-dimethylformamide, 1-methyl-1H-1,2,4-triazole, 1-methyl-imidazole and 1H-pyrazole. For these analytes and within shorter sampling times, Vac-HSSPME yielded detection limits (0.5-100 ng L-1) 3-10 times lower than those reported for regular HSSPME. Vac-HSSPME sampling for 30 min at 50 °C yielded the best combination of analyte responses and their standard deviations (<15%). 1-Formyl-2,2-dimethylhydrazine and formamide were discarded because of the poor precision and accuracy when using Vac-HSSPME. The recoveries for the rest of the analytes ranged between 80 and 119%. The modified Mininert valve and Thermogreen septum could be used for automated extraction as it ensured stable analyte signals even after long waiting times (>24 h). Finally, multiple Vac-HSSME proved to be an efficient tool for controlling the matrix effect and quantifying UDMH transformation products.

Journal of Chromatography A published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Keyari, Charles M.’s team published research in Journal of Medicinal Chemistry in 56 | CAS: 763120-58-7

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Application of 1H-Pyrazole-4-boronic acid.

Keyari, Charles M. published the artcileSynthesis of New Quinolinequinone Derivatives and Preliminary Exploration of their Cytotoxic Properties, Application of 1H-Pyrazole-4-boronic acid, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3806-3819, database is CAplus and MEDLINE.

A series of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were synthesized, characterized, and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor agents. The synthesis of lavendamycin analogs is illustrated. Metabolism studies demonstrated that 7-amino analogs were generally better substrates for NQO1 than 7-amido analogs, as were compounds with smaller heteroaromatic substituents at the C-2 position. Surprisingly, only two compounds, 7-acetamido-2-(8′-quinolinyl)quinoline-5,8-dione and 7-amino-2-(2-pyridinyl)quinoline-5,8-dione, showed selective cytotoxicity toward the NQO1-expressing MDA468-NQ16 breast cancer cells vs. the NQO1-null MDA468-WT cells. For all other compounds, NQO1 protected against quinoline-5,8-dione cytotoxicity. Compound I showed potent activity against human breast cancer cells expressing or not expressing NQO1, with resp. IC50 values of 190 nM and 140 nM and a low NQO1-mediated reduction rate, which suggests that the mode of action of I differs from that of lavendamycin and involves an unidentified target(s).

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Application of 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Songsichan, T.’s team published research in SynOpen in 2 | CAS: 930-36-9

SynOpen published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C5H6BNO2, Synthetic Route of 930-36-9.

Songsichan, T. published the artcileThiocyanation of Pyrazoles Using KSCN/K2S2O8 Combination, Synthetic Route of 930-36-9, the publication is SynOpen (2018), 2(1), 0006-0016, database is CAplus.

A convenient and practical thiocyanation of pyrazoles employed a combination of KSCN and K2S2O8 in DMSO (DMSO) was reported. The salient features of the present reaction included environmentally benign reagents, solvents and simple operation. The reaction showed wide functional group tolerance and gave moderate to excellent yields.

SynOpen published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C5H6BNO2, Synthetic Route of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Alvarez, Eva Maria’s team published research in Angewandte Chemie, International Edition in 60 | CAS: 930-36-9

Angewandte Chemie, International Edition published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Alvarez, Eva Maria published the artcileLate-Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α-Amino Alkyl Radicals, Application of 1-Methylpyrazole, the publication is Angewandte Chemie, International Edition (2021), 60(24), 13609-13613, database is CAplus and MEDLINE.

We report a late-stage heteroarylation of aryl sulfonium salts through activation with α-amino alkyl radicals in a mechanistically distinct approach from previously reported halogen-atom transfer (XAT). The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of heteroarenes. Furthermore, we demonstrate the applicability of this methodol. in synthetically useful cross-coupling transformations.

Angewandte Chemie, International Edition published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics