Analyzing the synthesis route of 2458-26-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6, Computed Properties of C9H8N2

Jert-butyl (H)-( 1 -(3-phenyl-1H-pyrazol- 1 -yl)propan-2-yl)carbamate 3-Phenyl-1 H-pyrazole (200 mg, 1 .39 mmol), cesium carbonate (4.52 g, 13.90 mmol) and (fi)-2-((tert-butoxycarbonyl)amino)propyl methanesulfonate (704 mg, 2.78 mmol) were combined in anhydrous A/,A/-dimethylformamide (4 ml). The resulting suspension was heated to 50 C and the progress of the reaction was monitored by TLC. Once the reaction was complete (~ 3 h) the reaction mixture was quenched by addition of water and the product was extracted with ethyl acetate three times. The organic layers were combined and washed with a saturated aqueous solution of sodium chloride. The crude material was purified by column chromatography, eluting 20% ethyl acetate/petroleum spirits to give the title compound as a colourless solid (177 mg, 42%). LRMS [M+H]+ 302.2 m/z; HRMS [M+H]+ 302.1863 m/z found 302.1864 m/z; 1H NMR (400 MHz, CDCI3) delta 7.86 – 7.73 (m, 2H), 7.43 – 7.35 (m, 3H), 7.33 – 7.27 (m, 1 H), 6.55 (d, J= 2.3 Hz, 1 H), 5.08 (s, 1 H), 4.27 (dd, J = 13.7, 4.5 Hz, 1 H), 4.23 – 4.13 (m, 1 H), 4.05 (dd, J= 12.7, 5.8 Hz, 1 H), 1 .43 (s, 9H), 1 .14 (d, J = 6.8 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MONASH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA; BAELL, Jonathan; PIGGOTT, Matthew; RUSSELL, Stephanie; TOYNTON, Arthur; RAHMANI, Raphael; FERRINS, Lori; NGUYEN, Nghi; (178 pag.)WO2015/172196; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of 866837-96-9

Statistics shows that Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 866837-96-9.

Reference of 866837-96-9, These common heterocyclic compound, 866837-96-9, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1 -Phenyl-5-(3-phenyl-ureido)-1 H-pyrazole-3-carboxylic acid 145,3mg (3,63mmol, 1 ,2Eq) of a 60%suspension of NaH in mineral oil aresuspended in 25ml of dioxane, 700mg (3,03 mmol) of ethyl 5-am ino-1 -^-fluorophenyl)-. H-pyrazole-3-carboxylate are added and the resulting mixture is stirred for 10 minutes at RT: Then phenylisocanate (360, 6mg, 3,03mmol, 1 Eq) is added and the resulting mixture is heated to 80C for 5hours. After cooling 7ml of 1 M NaOH are added and the resulting mixture is stirred overnight at RT. The solvent is evaporated in vacuo and the obtained crude product is subjected to HPLCchromatography. 257mg (26%) of the pure product are obtained.

Statistics shows that Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 866837-96-9.

Reference:
Patent; SANOFI; RUF, Sven; SADOWSKI, Thorsten; HORSTICK, Georg; SCHREUDER, Herman; BUNING, Christian; OLPP, Thomas; WIRTH, Klaus; WO2012/101199; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Share a compound : 5334-39-4

The synthetic route of 5334-39-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H5N3O2

A suspension of 3-methyl-l-(4-(methylsulfonyl)phenyl)-4-nitro-lH-pyrazole compound and 5-methyl-l-(4-(methylsulfonyl)phenyl)-4-nitro-lH-pyrazole (0.57 g, 2.0 mmol) and palladium on carbon (10 wt%, 0.2 g) in ethanol was stirred under a hydrogen atmosphere at 55 C for 18 hours. The reaction mixture was filtered through celite and concentrated to give the title compounds as a mixture of regioisomers (446 mg, 87%).

The synthetic route of 5334-39-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; BURDICK, Daniel Jon; CHAMBERS, Mark; CHEN, Huifen; ESTRADA, Anthony; SWEENEY, Zachary Kevin; CHAN, Bryan K.; WO2012/62783; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Continuously updated synthesis method about 309740-49-6

The synthetic route of 309740-49-6 has been constantly updated, and we look forward to future research findings.

Application of 309740-49-6,Some common heterocyclic compound, 309740-49-6, name is Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate, molecular formula is C6H7N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 1 -methyl-4-nitro-1 H-pyrazole-5-carboxylate (10 g, 51.31 mmol, 1. eq.) and palladium carbon (11.50 g, 103 mmol, 2.00 eq) was suspended in methanol (100 ml_). The resulting solution was stirred under hh atmosphere for 16 h at 25 C. The solids were filtered. The resulting mixture was concentrated under vacuum. The residue was purified by column chromatography (Method A). Methyl 4-amino-i -methyl-i H-pyrazole-5-carboxylate was isolated as a pink solid, (9 g, quant); LCIMS (Method J): Rt 0.64i mi [MH]+ i56.i mlz.

The synthetic route of 309740-49-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; BURGDORF, Lars; TSAKLAKIDIS, Christos; (177 pag.)WO2020/49017; (2020); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sources of common compounds: 3-Methyl-4-nitro-1H-pyrazole

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-4-nitro-1H-pyrazole, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-39-4, Computed Properties of C4H5N3O2

: To a solution of l-ethyi-5-hydroxy-piperidin-2-one (530 mg, 3.70 mmol), 3-methyl-4-nitro-lH-pyrazole (706 mg, 5.55 mmol) and PPrn (i ,46 g, 5.55 mmol) in THF (20 mL) was added dropwise DIAD (1.12 g, 5.55 mmol ) at 0 C over 20 min. After addition, the mixture was stirred at this temperature for 40 min, and then the resulting mixture was stirred at 20 C for 1 1 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 5: 1 to 0: 1) to give a mixture of l-ethyl-5-(5-methyl-4-nitro-lH-pyrazol-l- yi)piperidin-2~one and l~ethyl-5-(3~methyl-4-nitro-lH~pyrazol-l~yl)piperidin~2-one as a yellow solid. LCMS: RT 0.881 min, m/z = 253.1 [M+H]+ To a solution of l-ethyl-5-(5-methyl-4-nitro-pyrazol-l- yl)piperidin-2-one and l -ethyl-5-(3-metliyl-4-nitro-pyrazol-l-yl)piperidin-2-one (420 mg, 1.66 mmol) in MeOH (40 ml.) was added Pd/C (10%, 176 mg) under 2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 (15 psi) at 20 C for 2 h. The reaction mixture was filtered and the filtrate was concentrated to give a mixture of 5-(4-amino-5-methyl-lH- pyrazol-l-yl)-l-ethylpiperidin-2-one and 5-(4-atnino-3-methyl-lH-pyrazol-l-yl)-l-ethylpiperidin-2-one as a brown oil , LCMS: RT 0.566 min, m/z = 223 ,3 [M+Hf. To a solution of 5-(4-amino–5-methyi-pyrazoi-1–yl)-i -ethyl-piperidin-2.-one and 5-(4-arnino-3-rnetlwi-pyrazoi- I -yl)- I .-ethyl-piperidin.-2-one (310 rng, 1.39 mmoi), and 4-cyciopropvi-2-(methyisuifonyi)-5-(trifiuoromethyi)pyrimidine (370 mg, 1.39 mmoi)in 1,4-dioxane (10 mL) was added TFA (317mg, 2.78 mmol). The mixture was stirred at 100 c for 2 h. The reaction mixture was diluted with H,O (30 mL), adjusted with aq. NaHCO3 (30 mU) to pH 8 and extracted with EtOAc (3 x 30 mE). The combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give crude product. The crude product was triiurated with DMF (5 mE). The undissoived solid was filtered to givecrude product as a solid. This ciude product was separated by SFC to give 5-(4-((4-cyclopropyl–5- (trfiuoroniethyl)pyriniidin-2-yl)arnino)-3-methyl- 1H-pyrazoi- 1 -yl)- I -ethylpiperidin-2-one as a single enantiomer (Peak I in SFC) and 5-(4-((-cyciopropvi-5-(trifiuoromethyi)pvrimidin-2-yi)amino)-3- methyl-I H-pyrazol-1 -yi)-I -ethyipiperidin-2-one as a single enantiomer (Peak 2 in SFC). The DMF filtrate was concentrated to give crude product. This crude product was puiified by prep-HPLC TFA) and thentwice of SFC to give 5-(4-((-cyclopropyI-5-(tf1uoroinethyl)pyriinidin-2-yi)arnino)-5-metliyI- 1H- pyrazoi-i-yi)-i-cthyipiperidin-2-one as a single enantiomer (Peak 1 in SFC) and 5-(4–((4-cyciopropyi-5- (trifiuoroniethyl)pyrimidin-2-yi)amino)-5–mcthyi- I H-pyrazoi- 1 -yl)- I -ethyipiperidin-2-one as a single enantiomer (Peak 2 in SFC).First eluting isomer (Peak 1): (S)-5-(4-((4-cyclopropyl-5-(trifluoromethyl)pyrimidin-2-yI)ainino)-5-inethyl-IH-pyrazol4-yl)-1-ethylpiperidin-2-one (4-59): 1H NMR (400 MHz, MD3OD): dppm 8.25 – 8-45 (m. 1 H), 748 – 767 (m, I H), 4.64 4.79 (in, I H), 3.72 – 3.8-4 (in. 1 H), 356 – 363 (m,1 H), 344 – 354 (m, 1 H), 3.35 – 3.43 (in, I H), 2.50-2.61 (m, 2 H), 232 -244 (rn, I H), 2.25 (s, 3 H),2.09 -2.21 (in, 2 H), 0.98 1.34 (in, 7 H). HPLC: RT 2.480 miii. MS: m: 409.2 FM-f-Hi?. SFC: RT 5.72mm, == 100%.Second ehiting isomer (Peak 2): 5-(4-((4-cyclopropyl-5-(trifluoromethyi)pyrimidin-2-y)amino)-5-methy1-1H-pyrazoi-1-yl)-1-ethypiperidin-2-one (A-60): 1H NMR (400 MHz, CD3OD): dppm 8.21 – 8.48 (in, 1 H), 743 – 7.71 (in, I H), 4.67 – 4.80 (in, I H), 3.72 – 3.83 (in, I H), 356 – 362 (in,I H), 344 – 3.54 (in, 1 H), 3.34 – 3.43 (in, I H), 2.49 – 2.60 (in, 2 H), 233 – 244 (in, I H), 2.25 (s, 3 H),2.08 -2.21 (in, 2 H), 0.97- 1.34 (rn, 7 H). HPEC: RT 2.487 mm. MS; m/z; 409.1 [M+Hf. SFC: RT 6.33mm, cc = 100%.First eiuting isomer (Peak 1): 5-(4-((4-cyclopropvI-5-(trif1uoromethy)pvrimidin-2- yI)arnino)-3-rnethyl-1H-pyrazol-1-yl)-1.-ethylpiperidin-2-one (4-61): ?H NMR (400 MHz, CD3OD): oe ppm 8.34-8.43 (in, I H), 7.84 – 7.94 (in. I H), 4.54 -469 in, 1 H), 369 -3.79 (in, 2 H), 3.38-3.52 (in,2 H), 2.46- 2.57 (m. 2 H). 2.32-243 (m, 1 H). 2.22-2.30 (m, I H), 2.19 (s. 4 H). 1.18 – 131 (m, 2 H).1.07 – 1.17 (m, 5 Fl). FIPLC: RT 2.468 miii. MS: ith: 409.1 [M+Tlj. SFC: RT 4.87 miii, cc 100%. Second eluting isomer (Peak 2) :5-(4-((4-cyclopropyl-5-(trifluoromethyl)pyriinidin-2-yI)arnino)-3-rnethyi-1H-pyrazol-1-yI)-l -ethylpiperidin-2-one (A-62): ?H NMR (400 MHz, CD3OD): oeppm 8.34 – 8.42 (m, I H), 7.83 – 7.).S (m. I H). 4.56 – 471 (m, I H). 3.68 – 3.80 (m, 2 H), 3.37 – 3.53 (m.2 Fl). 2.45 – 2.58 (in, 2 H), 2.32- 2.43 (m, I H), 2.23 -2.30 (in, 1 Fl). 2.19 (s, 4 H), 1.19- 1.30 (m, 2 H),1.06 – 1.18 (in, 5 H). HPLC: RT 2.464 mm. MS: rn/i?: 40g. I [M+Hf. SFC: Rf 5.67 mm, cc 98.02%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-4-nitro-1H-pyrazole, and friends who are interested can also refer to it.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Simple exploration of 1-Methyl-4-nitro-1H-pyrazole

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H5N3O2

A solution of l-methyl-4-nitro-lH-pyrazole (9.7 g, 76.7 mmol) and 4-pentenal (10 g, 84.4 mmol) in dry THF (250 mL) was cooled to -78 C and stirred under nitrogen. A solution of LiHMDS (1 M in THF, 192 mL, 191.7 mmol) was added dropwise over a period of 3 hr. The reaction mixture was allowed to warm and to -40 C and stirred for 2 hr, quenched by dropwise addition of saturated ammonium chloride solution (100 mL), warmed to room temperature and diluted with EtOAc (200 mL). The organic layer was washed with saturated ammonium chloride solution (50 mL), separated, dried over MgS04 and the solvent removed under reduced pressure. Purification via silica gel chromatography (0-100% EtOAc/DCM) followed by silica gel chromatography (0-100% EtOAc/isohexane) to gave l-(l-methyl-4- nitro-lH-pyrazol-5-yl)pent-4-en-l-ol as a pale yellow oil (5.75 g, 36%). NMR (400 MHz, CDC13) delta 8.06 (s, 1H), 5.85-5.78 (m, 1H), 5.32-5.26 (m, 1H), 5.12-5.04 (m, 2H), 3.98 (s, 3H), 3.45 (d, / = 8.7 Hz, 1H), 2.92-2.09 (m, 3H), 1.90-1.86 (m, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BURCH, Jason; CHEN, Huifen; WANG, Xiaojing; WO2015/140189; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 1-Methyl-4-nitro-1H-pyrazole

The synthetic route of 1-Methyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 3994-50-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

At room temperature, pyrazole (0.2 mol) was dissolved in concentrated sulfuric acid (50 mL) and slowly raised to a temperature of 60 CConcentrated nitric acid (9.2 mL) was added and stirring was continued at 60 C for 1.5 hours.After completion of the reaction, the reaction solution was poured into 600 g of ice water, and the resulting white solid was separated by filtration and washed with water.After extraction with ethyl acetate (100 mL x 3), the organic phase was washed successively with 1% sodium bicarbonate solution (100 mL), water (100 mL) and physiological saline (100 mL), dried over anhydrous sodium sulfate and filtered, Finally, the organic phase liquid was rotary evaporated to give a white solid which was combined with the previously obtained white solid to give compound 2a. The resulting compound 2a (12 mmol) was dissolved in DMSO (9 mL)And potassium carbonate (10.9 mmol) was added successively thereto,Methyl iodide (6 mmol),8-hydroxyquinoline (1 mmol),CuI (0.58 mmol). Argon under the conditions of protection, stirMixed and heated to 130 C,After 20 hours of reaction,The reaction solution was poured into an appropriate amount of water,The resulting green solid was separated by filtration.The mother liquor was extracted with ethyl acetate (100 mL x 3). Finally, the organic phase liquid was evaporated to dryness and the resulting crude product was combined with the previously obtained green solid and purified by silica gel column chromatography to obtain Compound 4a. Compound 4a (1 mmol), hydrazine hydrate (0.5 mL) was added to ethanol (1 mL) and palladium on carbon (0.02 g) was added as catalyst.Heated at 80 C and refluxed for 10 minutes. After the completion of the reaction, the resulting mother liquor was subjected to rotary evaporation and drying to obtain Compound 5a. Compound 4a (1 mmol), hydrazine hydrate (0.5 mL) was added to ethanol (1 mL) and palladium on carbon (0.02 g) was added as catalyst.Heated at 80 C and refluxed for 10 minutes. After the completion of the reaction, the resulting mother liquor was subjected to rotary evaporation and drying to obtain Compound 5a. The compound 8a (1 mmol),EDC (1 mmol), HOBt (1 mmol) was added to DMF(3 mL) for 30 min.The compound 5a, DMAP (1 mmol), triethylamine (500 [mu] L) were added to the activated DMFSolution. At room temperature, stir overnight.After completion of the reaction, 100 mL of saturated sodium chloride solution was added to the reaction solution, and the mixture was washed with ethyl acetateEster extraction (200 mL x 3) extraction. Finally, the organic phase liquid was evaporated under vacuum and evaporated to dryness to obtain a crude product, using a silica gel columnSeparation and purification to give the final compound 9a to give a white solid powder in a yield of 86.4%

The synthetic route of 1-Methyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University; Zhu Hailiang; Shi Lu; Wang Zefeng; Wang Chenru; (14 pag.)CN107098861; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of 285984-25-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, its application will become more common.

Related Products of 285984-25-0,Some common heterocyclic compound, 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, molecular formula is C14H19N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 1-(4-((2-((3-Aminobenzo[d]isoxazol-5-yl)amino)pyrimidin-4-yl)oxy) naphthalen-1-yl)-3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea To a solution of CDI (56 mg, 0.35 mmol) in DCM (3.0 mL) was added Intermediate A1 (68 mg, 0.24 mmol) and the reaction mixture maintained at RT for 23 hr. The resulting solution was added to a solution of Intermediate B5 (50 mg, 0.098 mmol) in THF (3.0 mL) and the reaction mixture was kept at RT for 2 hr and was then partitioned between EtOAc (30 mL) and saturated aq. NaHCO3 (30 mL). The organic phase was separated and washed with saturated aq. NaHCO3 (30 mL), water (2*30 mL) and brine (2*30 mL), and then dried and evaporated in vacuo. The residue was purified by flash column chromatography (SiO2, 12 g, 0-100% EtOAc in isohexane, gradient elution) to afford tert-butyl (5-((4-((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzo[d]isoxazol-3-yl)carbamate (62 mg, 81%); Rt 2.88 min (Method 2, acidic); m/z 740 (M+H)+, (ES+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, its application will become more common.

Reference:
Patent; TOPIVERT PHARMA LIMITED; Duffy, Lorna Anne; King-Underwood, John; Longshaw, Alistair Ian; Murray, Peter John; Onions, Stuart Thomas; Taddei, David Michael Adrien; Williams, Jonathan Gareth; Ito, Kazuhiro; Charron, Catherine Elisabeth; US2015/203475; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Research on new synthetic routes about C4H6N2S

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1393128-21-6, name is 4-(Methylthio)-1H-pyrazole, A new synthetic method of this compound is introduced below., Quality Control of 4-(Methylthio)-1H-pyrazole

To a solution of CI (300 mg, 0.679 mmol) in acetone (6 mL) was added K2C03 (280 mg) and 4-(methylthio)- lH-pyrazole (115 mg, 1.01 mmol). The mixture was stirred at 25C for 4 hrs. The solvent was removed by rotary evaporator. To the mixture was added water (6 mL) and EtOAc (8 mL). The organic layer was separated. The aqueous phase was extracted with EtOAc (2 x 8 mL). The combined organic layers was washed with brine (10 mL), dried over Na2S04, filtered and evaporated to give a residue, which was purified by preparative HPLC to afford compound 21 (30.3 mg, 75%). [349] 21: (400 MHz, CDC13) delta 7.53 (s, IH), 7.41 (s, IH), 4.94- 4.87 (m, IH), 4.86-4.78 (m, IH), 3.53 (d, = 9.0 Hz, IH), 3.32 (s, 3H), 3.18 (d, = 9.0 Hz, IH), 2.61-2.52 (m, IH), 2.34 (s, 3H), 2.24-2.13 (m, IH), 2.08-1.99 (m, IH), 1.96-1.86 (m, 2H), 1.79-1.61 (m, 8H), 1.52-1.35 (m, 5H), 1.27 (s, 9H), 0.66 (s, 3H). LCMS Rt = 0.900 min in 1.5 min chromatography, MS ESI calcd. for C27H42N203SNa [M+Na]+ 497, found 497

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAGE THERAPEUTICS, INC.; ROBICHAUD, Albert, Jean; SALITURO, Francesco, G.; HARRISON, Boyd, L.; MARTINEZ BOTELLA, Gabriel; (157 pag.)WO2016/134301; (2016); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of 852227-86-2

The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.

Reference of 852227-86-2,Some common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, molecular formula is C6H9ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of NaH (64 mg, 1.59 mmol) in THF (4 mL) at 0 0C under argon was added 5-(chloromethyl)-l,3-dimethyl-lH-pyrazole (230 mg, 1.59 mmol) and allowed to stir for 20 minutes. (6-Bromopyridin-2-yl)methanol (150 mg, 0.80 mmol) was then added and the mixture was allowed to warm to room temperature and then heated to 55C overnight. The reaction was then cooled to ambient temperature and quenched by the addition of water. The quenched reaction mixture was diluted with water (10 mL) and DCM (10 mL) and shaken. The suspensions were passed through disposable phase separators and the DCM eluent was captured and evaporated to dryness to afford the title compound which was used without further purification. Calc’d for C12H15BrN3O [M+H]+: 296, Found 296.

The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2008/156726; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics