Category: 1393128-21-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1393128-21-6, name is 4-(Methylthio)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H6N2S

To a solution of SB-FF (100 mg, 0.24 mmol) in DMF (2 mL) was added Al (55 mg, 0.48 mmol) and K2CO3 (100 mg, 0.72 mmol) at 19C. The reaction was stirred at 19C for 16 h. The resulting mixture was poured into water (3 ml). The mixture was extracted with EtOAc (2 mL x 3). The combined organic layers was washed with brine (5 mL), dried over Na2S04 and concentrated in vacuum. The residue was purified by silica gel column (Petroleum ether/ethyl acetate = 10/1 to 3/1) to give SB-14 (80 mg, yield: 74%) as a pink solid. 1H NMR: (400 MHz, CDC13) delta 7.53 (s, 1H), 7.43 (s, 1H), 4.79-4.97 (m, 2H), 4.47-4.65 (m, 1H), 2.56-2.63 (m, 1H), 2.35 (s, 3H), 2.19-2.26 (m, 1H), 2.00-2.08 (m, 2H), 1.63-1.92 (m, 5H), 1.35-1.57 (m, 5H), 1.20-1.1.32 (m, 5H), 1.07-1.18 (m, 5H), 0.75-0.91 (m, 1H), 0.71 (s, 3H). LCMS: rt = 1.25 mm, m/z = 449.2 [M+H]+

The synthetic route of 1393128-21-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAGE THERAPEUTICS, INC.; BOTELLA, Gabriel Martinez; HARRISON, Boyd L.; ROBICHAUD, Albert Jean; SALITURO, Francesco G.; BERESIS, Richard Thomas; WO2014/169833; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1393128-21-6, name is 4-(Methylthio)-1H-pyrazole, A new synthetic method of this compound is introduced below., Quality Control of 4-(Methylthio)-1H-pyrazole

To a solution of CI (300 mg, 0.679 mmol) in acetone (6 mL) was added K2C03 (280 mg) and 4-(methylthio)- lH-pyrazole (115 mg, 1.01 mmol). The mixture was stirred at 25C for 4 hrs. The solvent was removed by rotary evaporator. To the mixture was added water (6 mL) and EtOAc (8 mL). The organic layer was separated. The aqueous phase was extracted with EtOAc (2 x 8 mL). The combined organic layers was washed with brine (10 mL), dried over Na2S04, filtered and evaporated to give a residue, which was purified by preparative HPLC to afford compound 21 (30.3 mg, 75%). [349] 21: (400 MHz, CDC13) delta 7.53 (s, IH), 7.41 (s, IH), 4.94- 4.87 (m, IH), 4.86-4.78 (m, IH), 3.53 (d, = 9.0 Hz, IH), 3.32 (s, 3H), 3.18 (d, = 9.0 Hz, IH), 2.61-2.52 (m, IH), 2.34 (s, 3H), 2.24-2.13 (m, IH), 2.08-1.99 (m, IH), 1.96-1.86 (m, 2H), 1.79-1.61 (m, 8H), 1.52-1.35 (m, 5H), 1.27 (s, 9H), 0.66 (s, 3H). LCMS Rt = 0.900 min in 1.5 min chromatography, MS ESI calcd. for C27H42N203SNa [M+Na]+ 497, found 497

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAGE THERAPEUTICS, INC.; ROBICHAUD, Albert, Jean; SALITURO, Francesco, G.; HARRISON, Boyd, L.; MARTINEZ BOTELLA, Gabriel; (157 pag.)WO2016/134301; (2016); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics