Application of 309740-49-6,Some common heterocyclic compound, 309740-49-6, name is Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate, molecular formula is C6H7N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 1 -methyl-4-nitro-1 H-pyrazole-5-carboxylate (10 g, 51.31 mmol, 1. eq.) and palladium carbon (11.50 g, 103 mmol, 2.00 eq) was suspended in methanol (100 ml_). The resulting solution was stirred under hh atmosphere for 16 h at 25 C. The solids were filtered. The resulting mixture was concentrated under vacuum. The residue was purified by column chromatography (Method A). Methyl 4-amino-i -methyl-i H-pyrazole-5-carboxylate was isolated as a pink solid, (9 g, quant); LCIMS (Method J): Rt 0.64i mi [MH]+ i56.i mlz.
The synthetic route of 309740-49-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; BURGDORF, Lars; TSAKLAKIDIS, Christos; (177 pag.)WO2020/49017; (2020); A1;,
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