Day: April 28, 2021

Related Products of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Stage 4: Synthesis of 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester; A 2OL reaction vessel equipped with a digital thermometer and stirrer was charged with 4- nitro-lH-pyrazole-3-carboxylic acid (1.117Kg, 7.11mol, lwt) and methanol (8.950L, 8vol). The reaction mixture was stirred under nitrogen, cooled to 0 to 50C, thionyl chloride (0.581L, 8.0mol, 0.52vol) added over 180 minutes and the resultant mixture allowed to warm to and stir at 18 to 22C overnight after which time 1H NMR analysis (d6-DMSO) indicated reaction completion. The reaction mixture was concentrated under reduced pressure at 40 to 450C, the residue treated with toluene and re-concentrated (3x 2.250L, 3x 2vol) under reduced pressure at 40 to 45C to give 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester as an off-white solid (1.210Kg, 99.5%th).; Stage 4: Preparation of 4-nitro-lH-pyrazole-3-carboxylic acid methyl; esterC4H3N3O4 C5H5N3O4FW: 157.09 FW: 171.114-Nitro-lH-pyrazole-3-carboxylic acid (1.00kg, 6.37mol, l.Owt) and methanol (8.00L, 8.0vol) were charged to a flange flask equipped with a mechanical stirrer, condenser and thermometer. The suspension was cooled to 0 to 5C under nitrogen and thionyl chloride (0.52L, 7.12mol, 0.52vol) was added at this temperature. The mixture was warmed to 15 to 25C over 16 to 24 hours. Reaction completion was determined by 1H NMR analysis (dbeta-DMSO). The mixture was concentrated under vacuum at 35 to 45C. Toluene (2.00L, 2.0vol) was charged to the residue and removed under vacuum at 35 to 45C. The azeotrope was repeated twice using toluene (2.00L, 2.0vol) to give 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester (1.071Kg, 98.3%) as an off white solid.

Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-3,5-dimethylpyrazole

A mixture of tert-butyl 3-(cyanomethyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate (381 mg, 0.981 mmol, from Example 1, step 2), 4-bromo-3,5-dimethyl-1H-pyrazole (206 mg, 1.18 mmol), tetrakis(triphenylphosphine)palladium(0) (110 mg, 0.098 mmol) and sodium carbonate (310 mg, 2.9 mmol) in 1,4-dioxane (10 mL) and water (5 mL) was purged with N2 and stirred at 110° C. for 2 h. The reaction mixture was filtered, diluted with EtOAc, then washed with water. The organic layer was concentrated and purified on silica gel (eluting with 0-100percent EtOAc/hexanes followed by 0-10percent MeOH/ dichloromethane) to give tert-butyl 3-(cyanomethyl)-3-(3?,5?-dimethyl-1H,1?H-4,4?-bipyrazol-1-yl)azetidine-1-carboxylate (90 mg, 26percent). LCMS calculated for C18H25N6O2 (M+H)+: m/z=357.2. Found: 357.2.

The synthetic route of 3398-16-1 has been constantly updated, and we look forward to future research findings.

Reference of 81945-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81945-73-5 name is 1H-Pyrazol-1-ol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(General Procedure 16)4-Cyclopentyl-piperazine-1-carboxylic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and N-cyclopentylpiperazine applying the general procedure 16. The crude product was purified by preparative HPLC (water-acetonitrile-0.1% TFA) (34%, salt with TFA). 1H NMR (300 MHz; CDCl3): delta 1.45-2.01 (m, 8H), 2.70 (bs, 4H), 2.92 (bs, 1H), 3.55 (bt, 1H), 3.63 (bs, 2H), 3.77 (bs, 2H), 6.31 (t, 1H), 7.38 (dd, 1H), 7.41 (dd, 1H); HPLC-MS: m/z=265.1 (M+1); Rt=0.54 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazol-1-ol, and friends who are interested can also refer to it.

Application of 4522-35-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4522-35-4, name is 3-Iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

INTERMEDIATE 58 4-(3-Iodo-lH-pyrazol-l-yl)pyrimidine-2-carbonitrile To a solution of 3-iodo-lH-pyrazole (298 mg, 1.536 mmol) in anhydrous DMSO (4 mL) added NaH (86 mg, 2.151 mmol) at 0 C. The mixture was stirred for 30 min at 0C, followed by the addition of 4-chloropyrimidine-2-carbonitrile (214 mg, 1.536 mmol) in DMSO(l mL). The resulting mixture was stirred at room temperature overnight. The mixture was quenched with water (10 mL) and extracted with EtOAc(40 mL x 3). The organic layer was collected and dried over Na2S04. The solvent was removed in vacuo to give the crude product. This was purified by flash chromatography (IS CO Combiflash, lOg, Biotage Si column, -30 mL/min, 100% hexanes 5min, gradient to 100% EtOAc in hexanes 15min) to afford 4-(3-iodo-lH- pyrazol-l-yl)pyrimidine-2-carbonitrile. LCMS calc. = 297.95; found = 297.92 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 113100-53-1,Some common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 3 (7.5 mmol)And thionyl chloride (30 mmol) were mixed and heated under reflux for 4 hours,And then cooled, soot the excess to remove the amount of thionyl chloride to get yellowColor liquid compound 41-methyl-3- (trifluoromethyl) -1H-pyrazole-4-carboxylic acid chloride.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, its application will become more common.

Electric Literature of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

General Procedure J; Preparation of a 4-amino-1H-pyrazole-3-carboxylic acid amideStep J (T). Preparation of a 4-nitro-1H-pyrazole-3-carboxylic acid amide4-Nitropyrazole-3-carboxylic acid (10 g; 63.66 mmol, 1 equiv.) was added to a stirred solution of an amine RNH2 (70 mmol, 1.1 equiv.), EDC (14.6 g; 76.4 mmol, 1.2 equiv.), and HOBt (10.3 g; 76.4 mmol, 1.2 equiv.) in DMF (250 ml), then stirred at room temperature overnight. The solvent was removed by evaporation under reduced pressure and the residue triturated with ethyl acetate / saturated brine solution. The resultant solid was collected by filtration, washed with 2M hydrochloric acid, then dried under vacuum to give 15.5 g of the amide compound.

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7

Cystamine dihydrochloride (1.90 g, 8.43 mmol), N-hydroxymethylpyrazole(3.32 g, 33.9 mmol) and triethylamine (1.76 g,17.5 mmol) dissolved in dichloromethane (50 mL) were stirredfor 24 h at RT. The reaction mixture was extracted with water(30 mL) three times, after which the organic layer was dried overMgSO4 and the solvent was evaporated. This yielded L3 as a colorlessoil (3.96 g, 8.38 mmol, 99%), which was used without furtherpurification. 1H NMR (300 MHz, CD3CN, RT): d 2.65 (t, J = 7 Hz,4H, S-CH2), 2.94 (t, J = 7 Hz, 4H, S-CH2-CH2), 5.07 (s, 8H, N-CH2-Pz), 6.27 (t, J = 2 Hz, 4H, N-CH-CH), 7.47 (d, J = 1 Hz, 4H, N-CH),7.63 (d, J = 2 Hz, N-CH). 13C NMR (75 MHz, CD3CN, RT): d 37.1 (SCH2),50.2 (S-CH2-CH2), 68.9 (N-CH2-Pz), 106.6 (N-CH-CH), 130.8(N-CH), 140.1 (N-CH). ESI-MS found (calculated) for [M+Na]+ m/z495.0 (495.2); [MC3+Na]+ m/z 459.0 (459.2); [M2 C3+Na]+ m/z422.9 (423.2); [M3 C3+Na]+ m/z 387.0 (387.2); [M4 C3+Na]+m/z 350.9 (351.2). IR (neat, cm1): 3110w, 2941w, 1513m,1393m, 1251m, 1121m, 1084s, 1046s, 962m, 743vs, 653m, 614s.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H8N2O

To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2 -amine (Intermediate E, 50 mg, O. l9mmol) and 1 -methyl -lH-pyrazol -4 -yl -methanol (207mg, l.85mmol) was added potassium 2-methylpropane-2-olate (1M in THF, l.85mL, l.85mmol) and the mixture was stirred for 30min. The mixture was transferred to a silica gel samplet which was subsequently loaded on to a Biotage Snap column. The residue was purified by column chromatography (Si02, hexane/ethyl acetate). Combined fractions were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5mL) and water (lOmL), frozen and lyophilized to yield 3-(3-((6-((l-methyl-lH-pyrazol-4- yl)methoxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (8.5mg, 0.023mmol, 13%) as a white solid. MS: 363.2 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 4-Bromo-1-cyclopropyl-1H-pyrazole

General procedure: A suspension of 1 -Difluoromethyl-4-(4,4,5,5 -tetramethyl-[ 1,3,21 dioxaborolan-2-yl)- 1H-pyrazole (1.47 g, 6.03 mmol), 4-bromo-2,6-difluorobenzaldehyde (1.1 g, 4.98 mmol), palladium acetate (0.03 g, 0.12 mmol), butyldi-1-adamantylphosphine (0.11 g, 0.3 mmol), and potassium carbonate (2.06 g, 14.93 mmol) in water (7 ml) and 1,4-dioxane (22 ml) in a tube was degassedfor 10 mm with argon, then the tube was sealed and heated at 100 C overnight. The reaction mixture was cooled to room temperature, concentrated under reduce pressure, the residue was diluted with EtOAc and washed with brine 2x then dried over Na2SO4, filtered and concentrated under reduced pressure. The crude residue was purified by silica column chromatography (10% to 25% EtOAc/Hex) to afford P7. 1HNMR (400 MHz, Chloroform-d) oe 10.32 (s, 1H), 8.16 (s,1H), 7.96 (s, 1H), 7.23 (t, J = 60.4 Hz, 1H), 7.14 (d, J = 9.5 Hz, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 82560-12-1, The chemical industry reduces the impact on the environment during synthesis 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, I believe this compound will play a more active role in future production and life.

a. 3-(5-Amino-3-tert-butyl-pyrazol-1-yl)-5-fluoro-phenol (Intermediate Wa) Degassed toluene (sparged with argon for 25 mins, 10.0 mL) was added to a mixture of 3-bromo-5-fluorophenol (1.00 g, 5.23 mmol), 3-tert-butyl-1H-pyrazole-5-amine (728 mg, 5.23 mmol), copper (I) iodide (50.0 mg, 0.26 mmol) and potassium carbonate (1.52 g, 11.0 mmol). Trans-N,N’-dimethylcyclohexanediamine (165 muL, 1.05 mmol) was added and the reaction heated to 150 C. for 3.5 h using microwave irradiation. The mixture was partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (3*). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-75% EtOAc in cyclohexane, to give the title compound (488 mg, 37%). LCMS (Method 4): Rt 2.49 min, m/z 250 [MH+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.