Synthetic Route of 82560-12-1, The chemical industry reduces the impact on the environment during synthesis 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, I believe this compound will play a more active role in future production and life.
a. 3-(5-Amino-3-tert-butyl-pyrazol-1-yl)-5-fluoro-phenol (Intermediate Wa) Degassed toluene (sparged with argon for 25 mins, 10.0 mL) was added to a mixture of 3-bromo-5-fluorophenol (1.00 g, 5.23 mmol), 3-tert-butyl-1H-pyrazole-5-amine (728 mg, 5.23 mmol), copper (I) iodide (50.0 mg, 0.26 mmol) and potassium carbonate (1.52 g, 11.0 mmol). Trans-N,N’-dimethylcyclohexanediamine (165 muL, 1.05 mmol) was added and the reaction heated to 150 C. for 3.5 h using microwave irradiation. The mixture was partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (3*). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-75% EtOAc in cyclohexane, to give the title compound (488 mg, 37%). LCMS (Method 4): Rt 2.49 min, m/z 250 [MH+].
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