Day: April 20, 2021

Adding a certain compound to certain chemical reactions, such as: 784193-37-9, name is 3-Bromo-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 784193-37-9, Recommanded Product: 3-Bromo-4-nitro-1H-pyrazole

To a mixture of 3-bromo-4-nitro-1H-pyrazole (6.20 g, 32.3 mmol) and K2CO3 (5.36 g, 38.7 mmol) in DMF (40 mL) was added MeI (5.50 g, 38.7 mmol) at 0 C. Then, the mixture was stirred at 25 C. for 2 hours. On completion, the mixture was diluted with water (200 mL), then extracted with EA (3¡Á80 mL). The combined organic layer was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography over silica gel (PE:EA=20:1-3:1) to give the title compound (3.90 g, 58% yield) as light yellow solid. 1H NMR (400 MHz, CDCl3) delta 8.16 (s, 1H), 3.97 (s, 3H).

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Electric Literature of 85290-80-8,Some common heterocyclic compound, 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 1-methyl-1H-pyrazole-4-carboxylate (20.2 g, 131 mmol) and NaOH (6.3 g, 158 mmol) in 200 mL absolute ethanol was refluxed for 2 h and stirring was continued at RT for 18 h. After that, the solvent was removed in vacuo. The residue was dissolved in water. The aq solution was washed with ether and acidified with concentrated HCl. The solid was filtered, washed with water and air-dried to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.

The synthetic route of 85290-80-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 26308-42-9

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one (0.100 g, 0.44 mmol) and 3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (0.074 g, 0.48 mmol), and pyridine (0.16 mL, 1.96 mmol) in acetonitrile (4 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.91 mL, 1.53 mmol). The sealed tube was heated to 50 C. for 5 days and the precipitation formed. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile/water to give 3-ethyl-1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-5-carboxamide (0.044 g, 26%). 1H NMR (400 MHz, DMSO-d): delta 12.64 (bs, 1H), 10.19 (s, 1H), 7.76 (m, 1H), 7.69 (dd, 1H, J=8.4, 2.0 Hz), 7.54 (s, 1H), 7.22 (s, 3H), 6.91 (d, 1H, J=8.0 Hz), 4.07 (s, 3H), 2.93 (t, 2H, J=7.2 Hz), 2.59 (m, 2H), 1.19 (t, 3H, J=7.6 Hz). MS (ESI): Calcd. for C19H19N5O2S: 381, found 382 (M+1)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37687-24-4, Recommanded Product: Diethyl 3,5-pyrazoledicarboxylate

To a solution of diethyl 1H-pyrazole-3,5-dicarboxylate (10.0 g, 47 mmol) and chloroacetone (3.76 mL, 47 mmol) in acetone (200 mL) was added potassium carbonate (7.2 g, 52 mmol). After heating at 30 C. for 6 h, the mixture was concentrated to remove the volatiles. The residue was taken into EtOAc and washed with water. The organics were dried over MgSO4 and concentrated to give diethyl 1-(2-oxopropyl)-1H-pyrazole-3,5-dicarboxylate as a light brown solid, which was used directly in the next step, MS m/z 269.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 3,5-pyrazoledicarboxylate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35277-02-2, name is 4-Fluoro-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 4-Fluoro-1H-pyrazole

4-Fluoro-1H-pyrazole (4.73 g, 55 mmol) and potassium carbonate (17.27 g, 125 mmol) were combined and stirred in N,N-dimethylformamide (41.7 mL) for 10 minutes in an open sealed tube before addition of 2-bromo-5-acetylpyridine (10 g, 50 mmol). The reaction tube was sealed and stirred 20 hours at 100C. The reaction mixture was then cooled to room temperature and poured into water (700 mL). The mixture was sonicated and stirred for 20 minutes. A beige solid was isolated by filtration, washed with small amounts of water, and dried to yield 1-(6-(4-fluoro-1H- pyrazol-1-yl)pyridin-3-yl)ethan-1-one (9.81 g, 96% yield). MS: M+1 = 206.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 143426-52-2 as follows. Recommanded Product: 1-(4-(Chloromethyl)phenyl)-1H-pyrazole

To a mixture of methyl 2-amino-3, 4-dimethyl-5- (4, 4, 5, 5- tetramethyl-1, 3, 2-dioxaborolan-2-yl) benzoate (0.69 g) , l-(4- (chloromethyl) phenyl) -lH-pyrazole (0.46 g) , 2 M aqueous sodium carbonate solution (2.26 mL) and DME (20 mL) was added (1,1- bis (diphenylphosphino) ferrocene) dichloropalladium ( II) (1707) dichloromethane adduct (0.09 g) under an argon atmosphere and the mixture was stirred at 80C overnight. The reaction mixture was dried over anhydrous sodium sulfate and (1708) concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.65 g) . (1709) MS: [M+H]+ 336.1

According to the analysis of related databases, 143426-52-2, the application of this compound in the production field has become more and more popular.

Related Products of 112029-98-8,Some common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 70 (160mg, 1 eq.) was dissolved in re-distilled dichloromethane, and dichlorosulfoxide (310 mul, 3 eq.) was added under ice bath. The mixture was reacted for 1 h, evaporated to remove solvent. The product was directly used in the next step without purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1-Methyl-1H-pyrazol-4-yl)methanol, its application will become more common.

Related Products of 14521-80-3, The chemical industry reduces the impact on the environment during synthesis 14521-80-3, name is 3-Bromo-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.19 g of 3-bromopyrazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50C for 1.5 hours. Then, the reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.31 g of 2-[3-(3- bromopyrazole-l-yl)pyridin-4-yl]-5-(trifluoromethyl)benzoxazole (hereinafter, referred to as “active compound 59”).Active compound 591H-NMR (CDC13) 6: 8.92 (s, IH), 8.89 (d, J=5.1 Hz, IH), 8.16 (d, J=5.1 Hz, IH), 8.08-8.07 (m, IH), 7.69 (dd, J=8.8, 1.2 Hz, IH), 7.66 (d, J=2.4 Hz, IH), 7.59 (d, J=8.8 Hz, IH), 6.57 (d, J=2.4 Hz, IH)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 37687-24-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-bromo-1-(3,4-dihydro-1H-isochromen-/-yl)ethanone (Intermediate 63A, 2.30 g, 8.1 mmol, 90% purity) in acetone (35 ml) were added diethyl 1H-pyrazole-3,5-dicarboxylate (1.56 g, 7.4 mmol) and potassium carbonate (2.75 g, 19.9 mmol). After stirring overnight at room temperature, the solids were filtered off, and the filtrate was concentrated under reduced pressure. The res-idue was purified by flash-chromatography on silica gel (eluent: petroleum ether/ethyl acetate 4:1)to give 2.40 g (83% of theory) of the title compound. LC/MS [Method 23]: Ri = 0.91 min; MS (ESlpos): m/z = 387 [M+H]?.1H-NMR (400 MHz, DMSO-d): 5 [ppm] = 7.84-7.86 (m, 1H), 7.76 (s, 1H), 7.35-7.38 (m, 2H), 6.20 (s, 2H), 4.77 (s, 2H), 4.31 (gq, 2H), 4.20 (q, 2H), 3.92 (t, 2H), 2.89 (t, 2H), 1.31 (t, 3H), 1.17 (t, 3H).

The chemical industry reduces the impact on the environment during synthesis Diethyl 3,5-pyrazoledicarboxylate. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 15802-80-9, name is 3-(tert-Butyl)pyrazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 15802-80-9

Part A – 4,5-Dibromo-3-tert-butylpyrazole Following the procedure of Example 30, Part A, but substituting 3-tert-butylpyrazole for 3-ethylpyrazole, there was prepared 4,5-dibromo-3tert-butylpyrazole with a melting point at 224 to 227 C. Analysis: Calc’d. for C7 H10 Br2 N2: C, 29.81; H, 3.57; N, 9.94. Found: C, 30.06; H, 3.68; N, 10.01.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15802-80-9, its application will become more common.