Day: March 17, 2021

Reference of 100114-57-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-chloro-N-(2 ,4-d imethoxybenzyl)-5-n itrobenzenesulfonamide (700 mg,1.81 mmol) in acetonitrile (14 mL) were added 3-cyclopropyl-1H-pyrazole (240 p1,2.71 mmol, CAS-RN 100114-57-6) and powdered potassium carbonate (750 mg,5.43 mmol) and the mixture was irradiated for lh at 120C in the microwave. 5-Cyclopropyl-1H-pyrazole (240 p1, 2.71 mmol) was added, and microwave irradiation wascontinued for 2h at 140C. The reaction mixture was filtered and concentrated in vacuo,and the residue was extracted with dichloromethane and water. The aqueous phase was washed three times with dichloromethane. Then the combined organic phases were washed with brine and dried using a Whatman filter. Concentration under reduced pressure led to the title compound that was purified by flash chromatography (187 mg, 21% yield, 95% purity).LC-MS (Method B): Rt = 1.34 mm, MS (ESIpos): mlz = 459 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 0.76 (m, 2H), 1.00 (m, 2H), 2.03 (m, 1H), 3.40 (s,3H), 3.60 (s, 3H), 4.17 (s, 2H), 6.11 (d, 1H), 6.28 (dd, 1H), 6.42 (d, 1H), 7.09 (d, 1H), 7.78 (d, 1H), 8.18 (d, 1H), 8.21 (d, 1H), 8.37 (t, 1H), 8.39 (dd, 1H).

The synthetic route of 3-Cyclopropyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 1260243-04-6, A common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate 1 (1.0 mmol), an appropriate aldehyde 2 (1.0 mmol) and aterminal alkyne 3 (1.0 mmol) in acetic acid (5 mL) was stirred at 25 ¡ãC for 10 min. The mixture was then stirred at 60 ¡ãC under ultrasound using a laboratory ultrasonic bath SONOREX SUPER RK 510H model producing irradiationof 35 kHz for 30 min in the presence of air. The increase of bath temperature beyond 60 ¡ãC due to the prolonged ultrasound irradiation was controlled by adding cold water time to time. After completion of the reaction the mixture was cooled to room temperature, poured into ethyl acetate (25 mL) and washed with brine solution (2 x 15 mL) followed by 10percent NaHCO3 solution (2 x 15 mL). The organiclayer was collected, dried over anhydrous Na2SO4, filteredand concentrated under low vacuum. The residue isolatedwas purified by column chromatography over silica gel using3-8percent petroleum ether-EtOAc to give the desired product.

The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 154471-65-5, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154471-65-5, Formula: C5H5F3N2

To a stirred solution of 11.5 g (76,6 mmol) 1-methyl-3-(trifluoromethyl)-1H-pyrazole (2) in dichloromethane (100 ml) was added 8.75 ml (79.8 mmol) of methyltriflate. The solvent was removed after stirring overnight at ambient temperature. Crystallization from MTBE gave 19 g (79 %) of the ionic liquid 6 as colourless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6, COA of Formula: C9H8N2

A solution of 2,2,2-trifluoro-1- (2-iodo-phenyl) -ethanol (0.331 g, 1.1 mmol), 3-phenylpyrazole (0.144 g,(0.1 L), (1R, 2R) -N, N’-dimethyl-cyclohexane-1,2-diamine (0.028 g, 0.2 mmol) and toluene (10 ml) were placed in a 20 ml pressure tube at 130 C (oil bath temperature)Under heating for 12 hours. The mixture was diluted with ethyl acetate, washed with H? O (2 x 20 ml), brine and dried over sodium sulfate. RemovedSolvent The crude product was purified by ISCO column chromatography using 5-10% ethyl acetate in hexanes as solvent to giveTo a solution of 2,2,2-trifluoro-1- [2- (3-phenyl-pyrazol-1-yl) -phenyl] -ethanol (75 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Benzyl-4-iodo-1H-pyrazole

Tri TBDMS derivative was obtained by treating 18 with TBDMSCl and imidazole in DMF. Lithiation with LTMP followed by quenching with tri n-butyltin chloride gave exclusively 2-stannyl derivative 20. Ammonolysis in 2-propanol gave 2-stannyladenosine 12. Stille coupling of 12 with 1 -benzyl-4-iodopyrazole in presence of Pd(PPl^ and CuI resulted in 21 (K. Kato et.al., J. Org. Chem. (1997), 62, 6833-6841). Deprotection of silyl groups on 2 upsilon and 5′ hydroxyls with 0.5 M ammonium fluoride in methanol gave 22 in good yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 26621-44-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 38 (S)-3-Cyclohexyl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-N-[1-((R)-2,3-dihydroxy-propyl)-1H-pyrazol-3-yl]-propionamide A solution of 3-nitro-1H-pyrazole (prepared as in Example 5, 3.00 g, 26.55 mmol) in N,N-dimethylformamide (15 mL) was treated with solid potassium carbonate (5.50 g, 39.82 mmol) and (S)-(-)-glycidol (3.93 g, 53.10 mmol) and placed in a sealed tube and heated at 100 C. for 1 h in an oil bath. After this time the N,N-dimethylformamide was removed in vacuo. Purification by ISCO flash chromatography (Teledyne Isco RediSep Flash Column 12 g; 0% to 10% methanol/dichloromethane) afforded (R)-3-(3-nitro-pyrazol-1-yl)-propane-1,2-diol (3.17 g, 64%) as a yellow oil: LR-ES-MS m/z calculated for C6H9N3O4 [M]+ 187, observed [M+H]+ 188.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1384973-12-9, name is 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1384973-12-9, Quality Control of 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile

A mixture of 5-amino-3-bromo-1H-pyrazole-4-carbonitrile 7b (10 g, 53.8 mmol), 3-(toluenesulfonyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester (22 g, 64.5 mmol), cesium carbonate (58 g, 107.6 mmol) and acetonitrile (250 mL) was heated to 90 C. and reacted for 4 hours, and was then cooled to room temperature, filtered and the resulting filter cake was washed with dichloromethane, the filtrates were combined and concentrated under reduced pressure, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate=5/1), so as to obtain the title product (S)-3-(5-amino-3-bromo-4-cyano-1H-pyrazol-1-yl)pyrrolidine-1-carboxylic acid tert-butyl ester 7c (5 g, yellow oil), and the yield was 26%. MS m/z (ESI): 300/302[M+1-56]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C3H3BrN2

General procedure: To a 20 ml or 40 ml viale quipped with a stir bar was added photocatalyst, nitrogen nucleophile, iodomesitylene dicarboxylate, copper salt, and ligand. Dioxane was added followed by addition of the base. The solution was sonicated for 1-3 min until it became homogeneous. Next, the solution was degassed by sparging with nitrogen for 5-10 min before sealing with Parafilm. The reaction was stirred and irradiated using two 34-W blue LED lamps (3 cm away, with cooling fan to keep the reaction at room temperature) for 1 h. The reaction mixture was removed from the light, cooled to ambient temperature, diluted with water (15 ml) and ethyl acetate (25 ml), and the aqueous layer was extracted with ethyl acetate (3 ¡Á 25 ml). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel to afford the desired decarboxylative C-N coupling product. For aniline substrates, a solution of these nitrogen nucleophiles in dioxane was used; additionally, if the iodomesitylene dicarboxylate is a liquid, its solution in dioxane was used.

The synthetic route of 3-Bromo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference of 64517-88-0, A common heterocyclic compound, 64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, molecular formula is C5H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[5]; 2-(6-Chlorobenzotriazol-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate was used in place of 2-(7-azabenzotriazol- 1 -yl)- 1 , 1 ,3,3-tetramethyluronium hexafluorophosphate(V) as the coupling agent. The product gave the following characterising data :- 1H NMR Spectrum: (DMSOd6) 2.13 (s, 3H), 3.66 (s, 2H), 3.70 (s, 3H), 3.78 (s, 3H), 6.77 (d, IH), 6.91 (m, IH), 7.06 (d, IH), 7.37 (d, IH), 7.81 (s, IH)5 8.08 (s, IH), 8.92 (s, IH), 9.44 (s, IH), 9.57 (d, IH); Mass Spectrum: M+H+ 438 and 440.

The synthetic route of 64517-88-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1355249-29-4, A common heterocyclic compound, 1355249-29-4, name is Ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxylate, molecular formula is C14H15IN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 15, Step D[00156] To a solution of 2-isopropoxy-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane (14.5 g, 77.2 mmol) and compound 15d (10 g, 25.9 mmol) in THF (10 mL) at -78 C was added n-BuLi (30 mL, 2.5 M in hexane, 75 mmol). The reaction mixture was stirred for 2 hrs at -78C, quenched with water and extracted with EtOAc (2 x 50 mL). The combined organic layers were dried over MgS04, filtered and concentrated in vacuum to give the crude product 15e (10 g, 100%) used directly without purification.

The synthetic route of 1355249-29-4 has been constantly updated, and we look forward to future research findings.