Day: March 16, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Product Details of 5334-43-0

General procedure: (General method). Amixture of the appropriate aminonitrile 1 (3.0 mmol) and1,3-dicarbonyl compound (3.0 mmol) in anhydrous toluene(12 ml) was refluxed for 1 h in a flask equipped with aDean-Stark trap. Tin(IV) chloride (3.0 g, 11.5 mmol) wasadded to the reaction mixture, and refluxing was continuedfor additional 5-6 h. A resinous precipitate was formed,andthe colorless toluene layer was decanted. The residualsolvent was removed on a rotary evaporator, the obtainedglassy solids were dissolved in boiling dioxane, cooled, thenpoured into a solution of Na23 (4.0 g) in water (70 ml).The precipitate that formed was filtered off, washed withwater, dried, and recrystallized from a 5:1 mixture of2-PrOH-DMF.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288246-16-2, HPLC of Formula: C4H2BrN3

To a solution of 4-bromo-3-cyano-lH-pyrazole 49 (172 mg, 1 mmol) in pyridine (3 mL) was added 2,5-difluorophenyl boronic acid (237 mg, 1.5 mmol), and 4A molecular sieves. The mixture was stirred for 72 h at room temperature. The reaction was worked-up with saturated NaHC0 and EtOAc extraction. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over a2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 50 (70 mg, 25%) as a blue wax.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-pyrazole-5-carbonitrile, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-13-1, name is 1H-Pyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

4-( 1 H-pyrazol- 1 -yl)- benzonitrile4-Fluorobenzonitrile (204.2 g), pyrazole (138.6 g, 1.22 eq) and potassium carbonate (281.5 g, 1.22 eq) in DMF (1110 ml) were heated at 120 0C for 7 hours. The suspension was cooled to 25 0C and water (2920 ml) added. The reaction was extracted with MTBE (3 x 1460 ml) and the combined extracts were washed with water (3 x 1460 ml) and saturated aqueous sodium chloride (1460 ml). The organic phase was concentrated at atmospheric pressure until the pot temperature rose to 65 0C. Heptane (1700 ml) was added over 30 minutes at 60-65 0C, and then a further 300 ml of distillate was collected. The solution was stirred at 60-65 0C for 15 minutes and then cooled to <5 0C. The slurry was filtered and washed with heptane (2 x 200 ml), and dried under vacuum to constant weight to give the title compound as a solid (245.3 g, 87%). 1H NMR (400 MHz, CDCl3): 6.51 (q, IH), 7.71 (d, 2H), 7.75 (d, IH), 7.81 (d, 2H), 7.98 (d, IH).

According to the analysis of related databases, 288-13-1, the application of this compound in the production field has become more and more popular.

Application of 14531-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of L1 (0.21 g, 1.5 mmol) in methanol (20 mL) wasadded drop wise, under continuous stirring, to a solution of coppernitrate trihydrate Cu(NO3)2¡¤3H2O (0.348 g, 1.5 mmol) in methanol(5 mL). The resulting blue solution was stirred at room temperature.After 30 min, a solution of 1,10-phenanthroline (0.297 g,1.5 mmol) was added to the mixture reaction, sensing a colourenhancement. The solution was stirred for more 30 min at roomtemperature. After filtration, the solution rests at room temperature.Suitable blue crystals for (1), appear in few days, and wereused for all measurements. Yield (based on Cu2+): 76%. ElementalAnal. Calc. for C22H24CuN10O11 (Mr = 668.04): C, 39.55; H, 3.62; N,20.97. Found: C, 39.43; H, 6.43; N, 21.02%. IR (KBr, sigma/cm-1): 3207(m), 3137(m), 3067 (m), 2997(m), 2897 (m), 1585 (s), 1509 (s),1392 (vs), 1360 (vs), 1170 (s), 1142 (m) 1114 (m), 1029 (w), 849(s), 725 (s), 674 (w), 569 (w), 428 (w).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 146941-72-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 146941-72-2, name is 4-Bromo-1-methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

A) To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (312 mg) in a mixed solvent of water (2.0 mL) and toluene (2.0 mL) was added itaconic acid (245 mg). The reaction mixture was stirred at 120 C. for 5 hr, and the solvent was evaporated under reduced pressure. The residue was used for the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Amino-1H-pyrazole-4-carbonitrile

Commercially available 5-amino-lH-pyrazole-4-carbonitrile (2.0 g, 18.5 mmol) was mixed with formamide (10 mL) and heated to 180¡ãC overnight under nitrogen. The solution was cooled to rt, 60 mL of water was added, and the resulting precipitate was collected by vacuum filtration to yield C (2.367 g, 95percent). 3/4 NMR (DMSO-d6, 300 MHz) delta 8.13 (s, 1H), 8.06 (s, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.

Reference of 68703-67-3,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-amino-1H-pyrazole-3-carbonitrile (270 mg, 2.4977 mmol) in DMF was added cyclopropane carboxylic acid (1.1 equiv., 2.7475 mmol), HBTU (1.2 equiv., 2.9972 mmol) and DIEA (10 equiv., 24.977 mmol). Upon reaction completion, the reaction was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layer was concentrated in vacuo and purified by flash column chromatography onsilica to give 109a. MS-ESI [M+H] = 177.1.

The synthetic route of 68703-67-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 81945-73-5, name is 1H-Pyrazol-1-ol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81945-73-5, Quality Control of 1H-Pyrazol-1-ol

Methyl-phenyl-carbamic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to flash chromatography (Quad flash 25, EtOAc-heptane) (79%, oil which slowly crystallizes). HPLC-MS m/z=218.1 (M+1), Rt: 2.82 min. Mp 63-67 C. deltaH(300 MHz; CDCl3): 3.45 (bs, 3H), 6.28 (s, 3H), 7.30-7.47 (m, 7H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 948570-75-0, Product Details of 948570-75-0

To a solution of 1-(2-methoxyethyl)-4-nitro-1H-pyrazole (1 equiv) in THF (0.5 M) was added dropwise lithium bis(trimethylsilyl)amide (2.7 equiv) in THF (1.0 M) at -78 C. The reaction was stirred at -78 C. for 30 min before the addition of hexachloroethane (1.5 equiv) in THF (1.84 M). The reaction was stirred at -78 C. for 2.5 h before warming to room temperature. The reaction was diluted with brine and extracted with ethyl acetate. The combined extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by flash chromatography (10-20% ethyl acetate in petroleum ether) to afford the desired product as a yellow solid (83% yield). 1H NMR (400 MHz, CHLOROFORM-d1) delta ppm 8.13 (s, 1H), 8.08 (s, 1H), 4.31-4.28 (t, J=4.2 Hz, 2H), 3.74-3.72 (t, J=5.36 Hz, 2H), 3.37 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 5334-40-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5334-40-7 name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-nitro-3-pyrazolecarboxylic acid (3.14 g,20.0 mmol) in MeOH (50 mL) was slowly added thionyl chloride(7.3 mL, 0.1 mol) at 0 C. After the completion of the addition, thetemperature of the reaction mixture increased to 70 C and stirredfor 5 h. Methanol was removed in vacuo, and the resulting residuewas poured into ice water and extracted with EtOAc. The organiclayer was washed with 10% NaHCO3 solution, brine and dried overNa2SO4. The resulting reaction mixture concentrated in vacuo toafford 1 as a white solid (3.37 g, 99%). 1H NMR (400 MHz, DMSO-d6)delta 8.93 (s, 1H), 3.89 (s, 3H); 13C NMR (100 MHz, DMSO-d6)delta 161.4,138.0, 133.7, 132.0, 53.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitro-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.