Category: 70817-26-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70817-26-4, name is (1-Phenyl-1H-pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., SDS of cas: 70817-26-4

(1 -Phenyl- lH-pyrazol-4-yl)~methanol (2 g) in dichloromethane (15 mL) was treated with thionyl chloride (10 mL) and the mixture stirred at 200C for Ih. The resulting suspension was diluted with wA¸hexane (15 mL) and the solid collected by filtration to afford the subtitled compound as an off-white solid (1.120 g).1H NMR (400 MHz, CDCl3) I’ 8.61 (IH, s), 7.84 – 7.80 (3H, m), 7.53 – 7.47 (2H, m), 7.35 7.30 (IH, m), 4.77 (2H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2009/153536; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 70817-26-4, These common heterocyclic compound, 70817-26-4, name is (1-Phenyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4) Will be 1.74 g (0.01 muM) 1 – phenyl -4 – hydroxymethyl pyrazole, in 100 ml of the single port in the bottle, by adding 35 ml dichloromethane, stirring in ice bath, dripping 1.43 g (0.012 muM) of thionyl chloride, device end gas collecting device, TLC monitoring after the reaction, reducing pressure and solvent, adding (3 × 50 ml) ethyl acetate extraction, the organic phase with saturated salt water 50 ml washing, desolvation residue after column chromatography (eluting agent is ethyl acetate with petroleum ether (reflux 60 – 90 C), the volume ratio of 1:4) shall be 1.55 g brown solid, yield 81.0%.

The synthetic route of 70817-26-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Liu Changling; Guan Aiying; Sun Qin; Yang Jinlong; Li Zhinian; Sun Xufeng; Xia Xiaoli; Ma Sen; Yang Fan; (63 pag.)CN107964007; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 70817-26-4, name is (1-Phenyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 70817-26-4

Example 14: (R)-3-(l-Phenyl-cycloheptanecarbonyloxy)-l-(l-phenyl-lH-pyrazol-4- ylmethyl)-l-azonia-bicyclo[2.2.2]octane chloridea) 4-Chloromethyl- 1 -phenyl- lH-pyrazole (1 -Phenyl- lH-pyrazol-4-yl)-methanol (2 g) in dichloromethane (15 mL) was treated with thionyl chloride (10 mL) and the mixture stirred at 200C for 1 h. The resulting suspension was diluted with z’s°hexane (15 mL) and the solid collected by filtration (1.12 g).1H NMR (399.826 MHz, DMSO-D6) delta 8.61 (s, IH), 7.84 – 7.80 (m, 3H), 7.53 – 7.47 (m, 2H), 7.35 – 7.30 (m, IH), 4.77 (s, 2H).

The synthetic route of (1-Phenyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan; WO2009/139709; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics