Category: 17827-61-1

Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; De Mendoza, Javier; Martin, M. Rosario published the artcile< NN'-linked biazoles. Part 4. Nucleophilic substitution in quaternary salts of NN'-linked biazoles and related systems>, SDS of cas: 17827-61-1, the main research area is nucleophile substitution biazolyl cation azolylpyridinium; pyridinium azolyl substitution nucleophile.

Some di- and monocationic N,N’-linked biazoles and quaternized 1-(N-azolyl)pyridinium ions were prepared and their reactions with nucleophiles were studied. Although the pyrrolyl nucleus is a poor leaving group in these reactions, in other cases nucleophilic attack readily occurs at an azolyl C, with subsequent elimination of the N substituent. E.g., reaction of dication I with NaCN in H2O at room temperature for 18 h gave 80% 2-cyano-1-methylbenzimidazole and 7% 1-methylbenzimidazol-2-one.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydrolysis kinetics. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, SDS of cas: 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Vasilevskii, S. F.; Shvartsberg, M. S. published the artcile< Oxidative iodination of substituted N-methylpyrozoles>, Computed Properties of 17827-61-1, the main research area is oxidation iodination methylpyrazole; pyrazole methyl oxidation iodination.

1-Methylpyrazole was iodinated in position 4 with iodine in aqueous KI with a low yield: introduction of an electron donor substituent in position 3 or 5 increased the reactivity of the heterocycle. Iodination of 5-amino-1,3-dimethylpyrazole gave 80% 4-iodide, but its N-acetyl derivative did not react. N-Methylpyrazole-4-carboxylic acids and -4-aldehydes underwent iodination under the same conditions and gave the 4-iodo or polyiodo derivative The presence of moderately strong electro acceptor substituents, e.g., iodo, or CO2Me, in the ring in the 4 position did not exclude the possibility of oxidative iodination at other positions of the ring. Strong electron acceptor groups, e.g., NO2, retard the reaction.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Iodination. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Computed Properties of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Rickborn, Bruce published the artcile< The retro-Diels-Alder reaction. Part II. Dienophiles with one or more heteroatom>, COA of Formula: C6H8N2O2, the main research area is review One; review II; review More; review Dienophiles; review Reaction; review Retro DielsAlder; review Part; review Heteroatom.

A review of the article The retro-Diels-Alder reaction. Part II. Dienophiles with one or more heteroatom.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, COA of Formula: C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Juanes, Olga; De Mendoza, Javier; Rodriguez-Ubis, Juan Carlos published the artcile< Synthesis of macrobicyclic ligands containing pyrazole subunits: the N,N'-bipyrazolyl cryptand>, Category: pyrazoles-derivatives, the main research area is bromomethylbipyrazole cyclocondensation ammonia diazatetraoxacyclooctadecane; pyrazole bromomethyl cyclocondensation ammonia diazatetraoxacyclooctadecane; amination bromomethylpyrazole; cryptand bipyrazolyl; methanamine pyrazolyl.

The cryptands I and II were prepared in 19 and 56% yield, resp., by reaction of 3,3′-bis(bromomethyl)-1,1′-bipyrazole with anhydrous NH3 and 4,13-diaza-1,7,10,16-tetraoxacyclooctadecane, resp., in dry MeCN at 100°. The tripodal pyrazolyl ligands III (R = H, Me, CH2Ph) were prepared analogously in 35, 41, and 39% yield, resp., by reaction of the appropriate pyrazoles IV with anhydrous NH3.

Journal of the Chemical Society, Chemical Communications published new progress about Amination. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Vasil’eva, V. F.; Yashunskii, V. G. published the artcile< Sydnones and sydnonimines. XIII. Reaction of 3-methyl- and 3-ethylsydnones with methyl acrylate>, HPLC of Formula: 17827-61-1, the main research area is .

Treatment of N-methylglycine with NaNO2 in aqueous HCl at 0°, followed by keeping the crude N-nitroso derivative with Ac2O 10 days at room temperature, gave 56.2% 3-methylsydnone (I), b0.7 162-5°. Similarly was prepared N-nitroso-N-ethylglycine, m. 85-6°, which with Ac2O gave 45.5% 3-ethylsydnone (II), b0.5 153-6°. Heating I with CH2:CHCO2Me 36 hrs. at 125-50° gave 56.5% Me 1-methyl-δ2-pyrazoline-3-carboxylate (III), b7 103-4°, d20 1.1162, n20D 1.5093, λ 306 mμ, and 24% crude Me x-carbomethoxy-1-methylpyrazoline-propionate (IV) (positions of attached groups not certain), b0.6 138-41°. The former in 2 days in MeOH-NH8 gave 1-methyl-δ2-pyrazolinecarboxamide, m. 116-18°, λ 296 mμ, while the latter ester gave the corresponding diamide, decomposed 241-2°. III and Pb(OAc)4 in AcOH (exothermic) gave 65% Me 1-methyl-pyrazole-3-carboxylate, b1 108-10°, which with MeOH-NH3 gave the corresponding amide, m. 139-40.5°, λ 220 mμ. 1-Methylpyrazole-4-carboxylic acid refluxed with MeOH-H2SO4 in C5H6 gave the Me ester, m. 63-4.5°, which with MeOH-NH3 1 day in a sealed tube gave the amide, m. 181.5-83°. II and CH2:CHCO2Me in 34 hrs. at 125° gave 51% Me 1-ethyl-δ2-pyrazoline-3-carboxylate (V), b7 110-12° b0.8 90° 1.0860, 1.5065, and some 25% crude 1-ethyl analog of IV, b0.5 135-42°. The former in MeOH-NH3 gave the amide, m. 92-4° while the latter ester similarly gave the diamide, decomposed 251-2°. V and Pb(OAc)4, as above, gave 62.5% Me 1-ethylpyrazole-3-carboxylate, b6 115-16°, which gave the amide, m. 100-1°. Infrared and ultraviolet spectra of the esters are reported.

Zhurnal Obshchei Khimii published new progress about IR spectra. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, HPLC of Formula: 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 17827-61-1, name is Methyl 1-Methylpyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O2

Step B: 1 -Methyl- lH-pyrazole-3-carboxamide (3)A solution of methyl l-methyl-lH-pyrazole-3-carboxylate (1.1 g, 7.9 mmol) in NuEta32Omicron (10 mL) was stirred for 2 h at room temperature. The solvent was evaporated to give the crude product which was used for the next step without further purification.

The synthetic route of Methyl 1-Methylpyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; MCCOMAS, Casey, C.; REGER, Thoma, S.; QI, Changhe; WO2014/150114; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17827-61-1, name is Methyl 1-Methylpyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2O2

To a solution of Ir(COD)2(OMe)2 (5.00 mg, 7.54 pmol, 0.02 equiv) and 4, 4, 5, 5- tetramethyl-l, 3, 2-dioxaborolane (68.5 mg, 535 pmol, 77.7 pL, 1.50 equiv) in -pentane (0.50 mL) was added 4-/er/-butyl-2-(4-/er/-butyl-2-pyridyl)pyridine (5.00 mg, 18.6 pmol, 0.05 equiv) and the mixture was stirred at 25 C for 20 minutes. To this mixture was added a solution of methyl l-methylpyrazole-3-carboxylate (50.0 mg, 357 pmol, 1.00 equiv) in -pentane (0.50 mL) and THF (0.50 mL) and the mixture was stirred at 25 C for 24 h. The mixture was partitioned between ethyl acetate (10.0 mL) and water (10.0 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated to afford the crude product methyl l-methyl-5-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole-3-carboxylate (50.0 mg, 113 pmol, 31.6% yield, 60.0% purity) as a black oil. 1H NMR (400MHz, CDCl3) d = 7.28 (s, 1H), 4.15 (s, 3H), 3.93 (s, 3H), 1.35 (s, 12H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17827-61-1, name is Methyl 1-Methylpyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 17827-61-1

Step 2: To a solution of step 1 intermediate (7.0 g, 50 mmol) in a mixture of THF (20 mL) and MeOH (20 mL) was added a solution of LiOH H20 (4.2 g, 100 mmol) in water (20 mL) at 0C. The RM was stirred at rt for 3 h. The RM was concentrated and subsequently diluted with water. The aqueous layer was acidified with sat. NaHS04 solution up to pH~4-5 and extracted with EtOAc. The combined organic layers were dried and concentrated under reduced pressure to yield the desired product (6.2 g, 98%). LC-MS (Method 3): m/z [M+H]+ = 127.2 (MW calc. 126.11); R, = 0.44 min.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.