Category: 368870-03-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 368870-03-5

The 9-cyclopentyl-2,6-dichloro-9H-purine (4.70 mmol) was dissolved in a mixture of n-propanol (15.0 ml) and N,N-diisopropyl-N-ethylamine (9.40 mmol) and to the solution 1 -[4-(1H-pyrazol-1 -yl)]phenylmethanamine (1.44 mmol) was added. The reaction mixture was heated in a sealedtube under an argon atmosphere at 100C. for 1.5 hour. Afier cooling to room temperature the resulting solid precipitate was suspended in ethanol (20 ml) and the precipitate was filtered off and washed with ice-cooled ethanol (20 ml). The crude product was dried at 80 C. for 2 hours and finally crystallized from ethanol. Yield: 72%, m.p.: 165-167 C. Elemental analysis: Calcd. for C2QH,9C1N60 (394.86): C, 60.84; H, 4.85; N, 21.28. Found: C, 60.56; H, 4.92; N, 21.48. HPLC-MS (ESI+): 394.3 (97.6%). ?H NMR (DMSO-d5):1. 61-1.71 (m, 2H), 1.80-1.98 (m, 4H), 2.09-2.18 (m, 2H), 4.66 (d, J=5.25, 2H, CH2), 4.77 (qui, J=7.05, 1H, CH), 6.51 (t, J=2.16, 1H,ArH), 7.45 (d, J=8.37, 2H,ArH), 7.71 (d, J=2.16, 1H, ArH), 7.77 (d, J=8.37, 2H, ArH), 8.27 (s, 1H, CH), 8.43 (d, J=2.16, 1H, ArH), 8.86 (t, J=5.25, 1H, NH)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6 mmol of compound III was dissolved in 30 mL of N, N-dimethylformamide (DMF), followed by 30 mmol of 4-dimethylaminopyridine (DMAP). 7 mmol of intermediate IIb was added thereto at room temperature. After the addition, the temperature was raised to 100 C for 16 hours. The reaction was stopped, the reaction solution was poured into ice water, and extracted with ethyl acetate several times. After the organic phase was dried, the obtained crude product was concentrated and separated by column chromatography to obtain the target Ib.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.

Application of 368870-03-5, These common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The corresponding acid (0.20 mmol), O-(1H-benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.24 mmol) and N-ethyldiisopropylamine (0.40 mmol) were mixed in DMF (1 mL) and stirred for 5 min under N2 atmosphere. Thereafter the amine component (0.20 mmol) was added and the inert atmosphere was restored. The mixture was stirred at room temperature for 16 hours then concentrated in vacuo and purified by column chromatography to furnish the amide product.

Statistics shows that (4-(1H-Pyrazol-1-yl)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 368870-03-5.