Application of 368870-03-5, These common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The corresponding acid (0.20 mmol), O-(1H-benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.24 mmol) and N-ethyldiisopropylamine (0.40 mmol) were mixed in DMF (1 mL) and stirred for 5 min under N2 atmosphere. Thereafter the amine component (0.20 mmol) was added and the inert atmosphere was restored. The mixture was stirred at room temperature for 16 hours then concentrated in vacuo and purified by column chromatography to furnish the amide product.
Statistics shows that (4-(1H-Pyrazol-1-yl)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 368870-03-5.