Category: 368870-03-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 368870-03-5

8 mmol of compound III was dissolved in 30 mL of THF, followed by 30 mmol of triethylamine. 7 mmol of intermediate IIc was added thereto under ice-cooling. After the addition is complete, continue to stir in the ice bath for 10 hours. The reaction was stopped, and the solvent was removed under reduced pressure. The obtained crude product was separated by column chromatography to obtain the target compound Ic.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 368870-03-5.

Reference:
Patent; Nantong University; Dai Hong; Liang Kai; Ni Yadan; Li Jinfeng; Shi Yujun; Gao Lei; Sui Ying; Zhou Huanyu; Zhou Qian; Yan Ruijian; (7 pag.)CN110713460; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 368870-03-5, SDS of cas: 368870-03-5

Method 2: General procedure for the preparation of examples 19-21 and 29-31 via urea formation with N,N’-carbonyldiimidazole.The corresponding primary amine (33.7 mg, 0.19 mmol) was dissolved in DMF (0.5 mL) and N,N’-carbonyldiimidazole (31.5 mg, 0.19 mmol) was added. The mixture was stirred for 20 min at room temperature a then the secondary amine (50 mg, 0.19 mmol) was added and the mixture was stirred at 8O0C for 16 h. The product urea was obtained by preparative HPLC purification. l-r3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazol-4-yll-l-methyl-3-r(4-pyrazol-l- ylphenvDmethyllureaThe titel compound was prepared by general method 2 using intermediate 11 and the commercially available (4-pyrazol-l-ylphenyl)methanamine. 1H NMR (400 MHz, CDCl3) delta (ppm) 7.91 (d, 1 H), 7.73 (d, 1 H), 7.57 – 7.62 (m, 2 H), 7.37 (br. s., 3 H), 7.26 (s, 2 H), 6.47 (s, 1 H), 5.01 (t, 1 H), 4.34 (d, 2 H), 3.13 (s, 3 H), 2.46 (s, 3 H); MS (ESI) m/z 456 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-1-yl)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10784; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 368870-03-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-(Pyrazol-1-yl)benzylamine (12.2 g, 0.07 mol) was dissolved in 50 mL of 2-methoxyethanol (75 mL) and 3-isopropyl-pyrimidine-5,7-dithiol (2) (13.3 g, 0.059 mol) was added under an atmosphere of nitrogen. The reaction mixture was heated at 120 C for 12 hours. The reaction product crystallized upon cooling to 10-15 C and was filtered off. After washing with 2-methoxyethanol, then THF, and drying in vacuo at 75 C, 13.7 g of product are obtained in 62% yield. The analytical sample was recrystallized from DMS0/H20, dried at 75 C under vacuum; m.p. 268-270 C (decomposition), UV (nm): 268 l, 288 l, 300 l, 336 l?. MS ESI+ 366.1 (M+H)+, ESI- 364.1 (M-H) . NMR (500 MHz; DMSO-d6): 1.23 (d, / = 7.03 Hz, 6H, -CH(C//3)2); 3.44 (bs, 1H, -C//(CH3)2); 4.75 (d, J = 6.11 Hz, 2H, -NH-G-); 6.50-6.51 (m, 1H, HAT); 7.46 (d, / = 7.95 Hz, 2H, HAT); 7.71 (d, / = 1.53 Hz, 1H, HAT); 7.79 (d, J = 8.25 Hz, 2H, HAT) ; 8.45 (d, J = 2.45 Hz, 1H, HAT) ; 9.17 (bs, 1H, -NH-); l2.23(bs, 1H, -NH); 13.74 (bs, 1H, -SH). 13C (125 MHz; DMSO-d6): 21.8; 42.4; 107.7; 118.3; 127.6; 128.7; 138.7; 140.8. Anal. (CI8H19N7S) C, H, N, S.

The synthetic route of (4-(1H-Pyrazol-1-yl)phenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERZITA PALACKEHO V OLOMOUCI; USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.; HAVLICEK, Libor; STURC, Antonin; REZNICKOVA, Eva; JORDA, Radek; KRYSTOF, Vladimir; STRNAD, Miroslav; (66 pag.)WO2019/149295; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 368870-03-5, These common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5 mmol of compound III was dissolved in 20 mL of N, N-dimethylacetamide (DMA),20 mmol of N, N-diisopropylethylamine (DIPEA) was then added.6 mmol of intermediate IIb was added thereto at room temperature. Gabi,The temperature was raised to 90 C for 22 hours.Stop the reaction, remove the solvent under reduced pressure,The obtained crude product was separated by column chromatography to obtain the target compound Ib.

The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nantong University; Dai Hong; Liang Kai; Ni Yadan; Li Jinfeng; Shi Yujun; Gao Lei; Sui Ying; Zhou Huanyu; Zhou Qian; Yan Ruijian; (7 pag.)CN110713460; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 368870-03-5, HPLC of Formula: C10H11N3

A solution of ethyl 2-(bromomethyl)-6-methoxybenzoate (0.50 g), (4-(1H-pyrazol-1-yl)phenyl)methanamine (0.32 g) and potassium carbonate (0.38 g) in ethanol (5 mL) was stirred under a nitrogen atmosphere at room temperature overnight. To the reaction solution was added water, and the resulting precipitate was collected by filtration, and dried. To the obtained white solid was added 25% hydrobromic acid (acetic acid solution) (5 mL), and the mixture was stirred under a nitrogen atmosphere at 120C overnight. The reaction solution was neutralized with saturated aqueous sodium hydrogen carbonate solution, and ethyl acetate was added. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by NH silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.31 g). 1H NMR (300 MHz, DMSO-d6) delta 4.31 (2H, s), 4.69 (2H, s), 6.48-6.58 (1H, m), 6.82 (1H, d, J = 8.3 Hz), 6.94 (1H, d, J = 7.6 Hz), 7.30-7.44 (3H, m), 7.73 (1H, d, J = 1.3 Hz), 7.82 (2H, d, J = 8.7 Hz), 8.46 (1H, d, J = 2.3 Hz), 9.63 (1H, brs).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-1-yl)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 368870-03-5, A common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 212-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-N-(4-pyrazol- l-yl-benzyl)-isobutyramide 2-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-2-methyl-propionic acid (75.0 mg, 0.268 mmol), 4-Pyrazol-l-yl-benzylamine (46.5 mg, 0.268 mmol), N-(3-dimethylaminopropyl)- N’-ethylcarbodiimide hydrochloride (51.5 mg, 0.268 mmol) and 1-hydroxybenzotriazole (18.1 mg, 0.134 mmol) were dissolved in methylene chloride (7.50 mL) and the reaction mixture was allowed to stir overnight at room temperature. The reaction was concentrated under reduced pressure and the residue was taken up in 1.2 mL of acetonitrile. Purification by mass-directed HPLC using a gradient of 25-75% MeCN/water both containing 0.1% TFA as the eluting solvent to afford 2-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-N-(4- pyrazol- l-yl-benzyl)-isobutyramide trifluoroacetic acid salt as a pale -yellow solid (33 mg,28%), mp = 47-53 C. MS: 435 (M+H); 1H-NMR (CDC13, 400 MHz) delta 7.92-7.83 (m, 3H), 7.80-7.76 (m, 1H), 7.64-7.57 (m, 4H), 7.30-7.25 (m, 2H), 7.21 (d, 1H, J = 15.6 Hz), 6.55 (d, 1H, J = 15.6 Hz), 6.52-6.47 (m, 1H), 5.73-5.63 (m, 1H), 4.44 (d, 2H, J = 5.7 Hz), 1.64 (s, 6H).

The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, A new synthetic method of this compound is introduced below., Formula: C10H11N3

A mixture of methyl 3-((tetrahydrofuran-2-yl)methoxy)-5-vinylisonicotinate (0.18 g) obtained in Reference Example 47, sodium periodate (0.71 g) and osmium oxide (immobilized catalyst I) (0.084 g) and acetonitrile (4 mL)-acetone (4 mL)-water (4 mL) was stirred at room temperature overnight. The insoluble material was filtered off, the filtrate was ethyl acetate and water, and the organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was dissolved in diethyl ether (5 mL)-THF (5 mL), (4-(1H-pyrazol-1-yl)phenyl)methanamine (0.10 g) and anhydrous magnesium sulfate (0.15 g) were added, and the mixture was stirred under a nitrogen atmosphere at room temperature for 1 hr. The insoluble material was filtered off, and the filtrate was concentrated. To a solution of the residue in acetic acid (5 mL) was added sodium triacetoxyhydroborate (0.28 g), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with water and ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by NH silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.095 g). MS: [M+H]+ 391.2 1H NMR (300 MHz, DMSO-d6) delta 1.73-1.90 (2H, m), 1.97-2.07 (2H, m), 3.62-3.75 (1H, m), 3.82 (1H, t, J = 7.1 Hz), 4.20-4.33 (3H, m), 4.44 (2H, s), 4.72 (2H, s), 6.46-6.59 (1H, m), 7.41 (2H, d, J = 8.5 Hz), 7.73 (1H, d, J = 1.7 Hz), 7.82 (2H, d, J = 8.5 Hz), 8.40-8.51 (3H, m).

The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.

Related Products of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate (UIPC-II-278)(28) (60 mg, 0.26 mmol) was refluxed in triethylorthoformate(0.110 mL, 0.65 mmol) and acetic anhydride (0.10 mL, 1.05 mmol) for 24 h to yield the intermediate enol ether (29). After the reactionwas complete, the mixture was concentrated in vacuo and thendissolved in ethanol. To this was added (4-(1H-pyrazol-1-yl)phenyl)methanamine (55 mg, 0.30 mmol) and the reaction wasallowed to stir at room temperature for 2 h. The reaction wasconcentrated in vacuo and purified by flash chromatography using agradient of dichloromethane:methanol. The reaction intermediatewas then dissolved in dioxanes, sodium hydride (13 mg,0.52 mmol) was added at 0 C and the reaction was allowed to stirfor 1 h. Once complete, the reaction was concentrated in vacuo anddiluted with water and extracted thrice with 10 mL ethyl acetate.The combined organic layers were washed with brine, dried overNa2SO4, filtered and concentrated in vacuo to afford 30b in 89%yield. 30b was used for the next step without further purification.MS ESI calculate for (M H) 392.136, found 392.13. Retention time(analytical HPLC) 18.1 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.

Related Products of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate (UIPC-II-278)(28) (60 mg, 0.26 mmol) was refluxed in triethylorthoformate(0.110 mL, 0.65 mmol) and acetic anhydride (0.10 mL, 1.05 mmol) for 24 h to yield the intermediate enol ether (29). After the reactionwas complete, the mixture was concentrated in vacuo and thendissolved in ethanol. To this was added (4-(1H-pyrazol-1-yl)phenyl)methanamine (55 mg, 0.30 mmol) and the reaction wasallowed to stir at room temperature for 2 h. The reaction wasconcentrated in vacuo and purified by flash chromatography using agradient of dichloromethane:methanol. The reaction intermediatewas then dissolved in dioxanes, sodium hydride (13 mg,0.52 mmol) was added at 0 C and the reaction was allowed to stirfor 1 h. Once complete, the reaction was concentrated in vacuo anddiluted with water and extracted thrice with 10 mL ethyl acetate.The combined organic layers were washed with brine, dried overNa2SO4, filtered and concentrated in vacuo to afford 30b in 89%yield. 30b was used for the next step without further purification.MS ESI calculate for (M H) 392.136, found 392.13. Retention time(analytical HPLC) 18.1 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, A new synthetic method of this compound is introduced below., Formula: C10H11N3

To a solution of methyl 2-(bromomethyl)-4-fluoro-6-iodobenzoate (2.54 g) obtained in Reference Example 99 in THF (30 mL) were added (4-(1H-pyrazol-1-yl)phenyl)methanamine (4.5 g), triethylamine (2.44 g) and potassium carbonate (1.67 g), and the mixture was heated under reflux under a nitrogen atmosphere for 12 hr. The reaction solution was diluted with water and ethyl acetate, and the organic layer was separated, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was solidified with petroleum ether-ethyl acetate to give the title compound (2.85 g). 1H NMR (400 MHz, CDCl3) delta 4.18 (2H, s), 4.81 (2H, s), 6.47 (1H, t, J = 2.0 Hz), 7.10 (1H, dd, J = 7.6, 2.0 Hz), 7.41 (2H, d, J = 8.8 Hz), 7.60-7.80 (4H, m), 7.91 (1H, d, J = 2.4 Hz).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.