Reference of 368870-03-5, These common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5 mmol of compound III was dissolved in 20 mL of N, N-dimethylacetamide (DMA),20 mmol of N, N-diisopropylethylamine (DIPEA) was then added.6 mmol of intermediate IIb was added thereto at room temperature. Gabi,The temperature was raised to 90 C for 22 hours.Stop the reaction, remove the solvent under reduced pressure,The obtained crude product was separated by column chromatography to obtain the target compound Ib.
The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nantong University; Dai Hong; Liang Kai; Ni Yadan; Li Jinfeng; Shi Yujun; Gao Lei; Sui Ying; Zhou Huanyu; Zhou Qian; Yan Ruijian; (7 pag.)CN110713460; (2020); A;,
Pyrazole – Wikipedia,
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