Category: 67-51-6

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.67-51-6, Name is 3,5-Dimethyl-1H-pyrazole, SMILES is C1=C(C)[NH]N=C1C, belongs to pyrazoles-derivatives compound. In a document, author is Weingart, Pascal, introduce the new discover, Formula: C5H8N2.

Electronic Fine-tuning of Ruthenium(II) Transfer Hydrogenation Catalysts with Ethanol as the Hydrogen Source

A series of ruthenium(II) complexes bearing tridentate N,N’-diallyl-2,6-di(5-butylpyrazol-3-yl)pyridine ligands was synthesized and characterized. Introduction of substituents in the 4-position of the pyrazole rings tune the electron density at the ruthenium center, which was proved by correlation of the P-31 NMR chemical shifts with the sigma(p) parameters of the Hammett equation. The structural elucidation of a phosphine-free ruthenium(II) complex proves that one of the allyl side-chains undergoes chelating coordination to the ruthenium site to realize a 18 VE center. This compound is the starting point for complexes of the type (N,N,N)Ru(L)(Cl)(2) bearing ligands L other than triphenylphosphine. The ruthenium(II) complexes were investigated for their activity in the transfer hydrogenation with ethanol as the hydrogen source. Here the logarithms of the measured turn-over frequencies (TOF) correlate with the sigma(p) parameters of the Hammett equation in terms of a linear free-energy relationship.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 67-51-6 is helpful to your research. Formula: C5H8N2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 67-51-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 67-51-6, Name is 3,5-Dimethyl-1H-pyrazole, SMILES is C1=C(C)[NH]N=C1C, belongs to pyrazoles-derivatives compound. In a article, author is Stapf, Manuel, introduce new discover of the category.

Cycloalkyl Groups as Subunits of Artificial Carbohydrate Receptors: Effect of Ring Size of the Cycloalkyl Unit on the Receptor Efficiency

1,3,5-Trisubstituted 2,4,6-triethylbenzenes consisting of isopropyl groups as recognition units have previously been shown to have interesting binding properties towards selected carbohydrates. The design of such artificial carbohydrate receptors was inspired by the mode of action of carbohydrate-binding proteins, namely by the participation of the isopropyl side chain of valine in the formation of van der Waals interactions with the carbohydrate substrate. This study aimed to investigate how the replacement of the isopropyl groups by other structural motifs, such as cycloalkyl groups of varying sizes (three to seven-membered rings), influences the binding properties of the acyclic compounds towards carbohydrates. The cyclopropyl moiety represents a cyclic analog of the isopropyl group, whereas the other cycloalkyl units can be regarded as structural elements, which differ from the structure of the isopropyl group by a -(CH2)(n)-bridge (n= 1-4) between the two methyl groups. Furthermore, according to the natural interactions, the cyclopentyl group should be able to participate in the formation of van der Waals contacts in a similar way as that observed for the pyrrolidine ring of proline in some protein-carbohydrate complexes. Such systematic binding studies allow the identification of interesting structure-activity relationships, which are very useful for the development of artificial carbohydrate receptors with predictable binding properties.

Synthetic Route of 67-51-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 67-51-6 is helpful to your research.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Related Products of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 1-(4-Methoxy-phenyl)-3,5-dimethyl-1-H-pyrazole: The title compound was prepared from 4-methoxyphenylboronic acid (1.58 g, 10.4 mmol), 3,5-dimethyl-1H-pyrazoles (0.5 g, 5.2 mmol) using the general procedure A with a yield of 90% (0.9 g,); MS (APCI) m/z: 203 (M+1, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethyl-1H-pyrazole, its application will become more common.

Synthetic Route of 67-51-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67-51-6 as follows.

General procedure: NaH (60mmol) was added to the solution of 3,5-dimethylpyrazole or 3,5-diisopropylpyrazole (50mmol) in THF (40ml) at room temperature. The resulting mixture was stirred for 1h, and then CH3I (50mmol) was added. After the reaction mixture was continuously stirred overnight at room temperature, water (100ml) was added slowly. The solution was extracted with ethyl acetate (3¡Á50ml). The organic layers were combined, washed with saturated brine and dried over anhydrous MgSO4. The solvent was removed in vacuo to give the expected products. (0012) 1,3,5-Trimethylpyrazole, yield: 46%. 1H NMR: delta 2.18 (s, 3H), 2.19 (s, 3H) (CH3), 3.67 (s, 3H, NCH3), 5.76 (s, 1H, H4 of pyrazole) ppm. 13C NMR: delta 11.0, 13.4 (CH3), 35.6 (NCH3), 104.8 (C4 of pyrazole), 139.0, 147.0 (C3 and C5 of pyrazole) ppm.

According to the analysis of related databases, 67-51-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

15.6 g (0.088 mol) of the above intermediate crude product was dissolved in 500 mL of acetone and 17.6 g (0.132 mol) of NIS was added.The reaction solution was placed in ultrasonic wave for 8 h, the temperature should not exceed 25-30 .The reaction solution was filtered and the filtrate was concentrated and the resulting residue was passed through a short silica gel column,Dichloromethane as eluent. And concentrated under reduced pressure to give an orange liquid (16.85 g)Is a crude product of 4-iodo-3,5-dimethyl-lH-pyrazole.

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 67-51-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67-51-6 name is 3,5-Dimethyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole. To a 16 mL vial containing 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol) and a magnetic stir bar, 0.7 mL of water and 0.3 mL of ethyl acetate was added. Next, NaCl (123 mg, 2 mmol) was added and the vial was placed in a room temperature water bath to control exotherms. Finally, Oxone (322 mg, 0.52 mmol or 1.05 mmol KHSO5) was added and the vial was capped. The reaction proceeded with continuous and vigorous stirring until no starting material remained as indicated by TLC (1 h). The remaining oxidants were reduced with solid sodium bisulfite until starch iodide paper tested negative. Water (5 mL) was added and the mixture was extracted with 1:1 hexanes/diethyl ether (3 x 5 mL). The combined organic fractions were dried (MgSO4) and concentrated to yield crude product that was purified by flash chromatography (14 x 1 cm), 9:1 hexane/ethyl acetate eluent. Pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole was obtained as a pale yellow oil (215 mg, 93% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethyl-1H-pyrazole, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 67-51-6

3,5-Dimethyl-1H-pyrazole, 78.5 g (0.818 mol), was dissolved in 700 mL of water heated to 70C, and 517 g (3.271 mol) of potassium permanganate was added to the hot solution, maintaining the temperature no higher than 90C. The mixture was cooled to room temperature, the precipitate of MnO2 was filtered off and washed with water, and the filtrate was acidified with aqueous HCl to pH 2 and left overnight. The precipitate was filtered off and washed with water. Yield 41.75 g (33%), white crystals, mp 257-258C. 1H NMR spectrum: delta 7.07 ppm, s (1H, 4-H). 5-Methyl-1H-pyrazole-3-carboxylic acid (2). The aqueous filtrate obtained after separation of diacid 1, was neutralized to pH 5-6, and the precipitate of 2 was filtered off and washed with water. Yield 18.1 g (18%), white crystals, mp 210-211C. 1H NMR spectrum, delta, ppm: 2.25 s (3H, CH3), 6.42 s (1H, 4-H).

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Application of 67-51-6, These common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Powdered potassium hydroxide (1.751 g, 31.2 mmol) was added to a solution of 3,5-dimethylpyrazole (2 g, 20.81 mmol) in anhydrous DMSO (10.40 ml) and the resulting heterogeneous solution was stirred for 1.5 hr at 80 C before being cooled to roomtemperature. 2-Chloro benzylchloride (2.64 ml, 20.81 mmol) was then added in 6 M DMSO over 15 min, and the solution was stirred for a further 1.5 hrs. Upon completion as observed by TLC, the reaction was poured over water and the resulting aqueous phase was extracted with two 20 mL portions of CHCI3. The combined organic layers were washed with 100 mL of water, dried with anhydrous MgS04 and concentrated under reduced pressure to yield 4.55 g (99%) of l-(2-chlorobenzyl)-3,5-dimethyl-lH-pyrazole as a clear liquid. 1H NMR (300 MHz, CDCI3) delta 7.41 – 7.31 (m, 1H), 7.24 – 7.09 (m, 2H), 6.59 – 6.50 (m, 1H), 5.90 (s, 1H), 5.31 (s, 2H), 2.26 (s, 3H), 2.15 (s, 3H). 13C NMR (75 MHz, CDCI3) delta 148.32, 139.96, 135.46, 131.96, 129.42, 128.76, 127.72, 127.48, 105.84, 50.12, 13.80, 11.15. HRMS (m z): [MNa]+ calc for C12Hi3ClN2Na+ 243.07; found 243.0651.

Statistics shows that 3,5-Dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 67-51-6.