Category: 75415-03-1

Synthetic Route of 75415-03-1,Some common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, molecular formula is C8H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-(1H-pyrazole-3-yl)pyridine (3.02 g, 20.80 mmol) and NBS (3.72 g, 20.90 mmol) in DMF (30 mL) was stirred for 2 h in an ice bath. The reaction mixture was poured into ice water, filtered, and dried in vacuo. The residue (4.38 g, 95% yield) as a white solid was reacted without further purification. 1H-NMR (270 MHz, CDCl3) delta: 11.46 (1H, br s), 8.63-8.65 (1H, m), 8.29 (1H, d, J = 8.4 Hz), 7.78-7.85 (1H, m), 7.64 (1H, s), 7.28-7.33 (1H, m). LC/MS (ESI): m/z 223 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Pyrazol-3-yl)pyridine, its application will become more common.

Reference:
Article; Sekimata, Katsuhiko; Sato, Tomohiro; Sakai, Naoki; Watanabe, Hisami; Mishima-Tsumagari, Chiemi; Taguri, Tomonori; Matsumoto, Takehisa; Fujii, Yoshifumi; Handa, Noriko; Honma, Teruki; Tanaka, Akiko; Shirouzu, Mikako; Yokoyama, Shigeyuki; Miyazono, Kohei; Hashizume, Yoshinobu; Koyama, Hiroo; Chemical and Pharmaceutical Bulletin; vol. 67; 3; (2019); p. 224 – 235;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, A new synthetic method of this compound is introduced below., name: 2-(1H-Pyrazol-3-yl)pyridine

EXAMPLE 12 The synthesis of 1,3-di(2-pyridyl)pyrazole (13). A mixture of compound 11 (22.2 g, 153 mmol) and 2-bromopyridine (42.3 g, 268 mmol) was heated for 20 h at 190 C. The cooled mixture was dissolved in hot H2 O (200 ml) and the pH was adjusted to basic with solid Na2 CO3. After cooling, the precipitate was filtered and washed with cold H2 O. Yield: 32.9 g (97%). UV (EtOH): 294, 283, 224. IR (KBr): 1593, 1578 (arom). 1 H-NMR (CDCl3): 7.14 (d, J=2.6, 1H); 7.21 (ddd, J=1.0, 4.9, 7.3, 1H); 7.27 (ddd, J=1.1, 4.9, 7.3, 1H); 7.79 (dt, J=1.7, 7.3, 1H); 7.85 (dt, J=1.7, 7.3, 1H); 8.12-8.16 (m, 2H); 8.44 (dd, J=1.7, 4.9, 1H); 8.64 (d, J=2.6, 1H); 8.68 (bd, J=4.9, 1H).

The synthetic route of 75415-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wallac Oy; US5859215; (1999); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, A new synthetic method of this compound is introduced below., Formula: C8H7N3

[Mn(m2-O)(H2O)2(HL)]2n2nNIPH (2): A mixture of Mn(OAc)24H2O (0.10 g, 0.4 mmol), H2NIPH (0.084 g, 0.4 mmol), L (0.058 g, 0.4 mmol), and 18 mL H2O was placed in a Teflon reactor (30 mL) and the pH value was adjusted to about 7 with 0.5 mol/L NaOH solution. Then the mixture was heated at 140C for 7 days. After cooling to room temperature at a rate of 10C/h, brown crystals of 1 were collected in 45% yield. Anal. Calcd. for C32H30Mn2N8O18 (%): C, 41.57; H, 3.27; N, 12.12. Found (%): 41.36; H, 3.01; N, 11.98. IR (KBr, cm-1): 3413(m), 3102(w), 1630(s), 1606(s), 1583(m), 1533(m), 1495(w), 1443(w), 1334(s), 1101(w), 998(w), 788(w), 720(m), 537(w).

The synthetic route of 75415-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Zhi-Tao; Valtchev, Valentin; Fang, Qian-Rong; Li, Xiu-Mei; Pan, Ya-Ru; Inorganic and Nano-Metal Chemistry; vol. 49; 2; (2019); p. 44 – 50;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75415-03-1 as follows. Safety of 2-(1H-Pyrazol-3-yl)pyridine

A mixture of HL (0.2 mmol, 29 mg), Zn(NO3)26H2O (0.2 mmol, 59 mg),ethanol (1 ml), and H2O (10 ml) was stirred for 0.5 h in air, then the resulting mixture was transferred in a Teflon-linedstainless reactor and heated to 140 C for 3 days under autogenous pressure and cooled to room temperature at a rate of10 C/h. Consequently, the colorless block-shaped crystals suitable for X-ray single crystal diffraction were obtained witha yield of 36.7 % (based on Zn(NO3)26H2O)

According to the analysis of related databases, 75415-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu; Huan; Cui; Han; Journal of Structural Chemistry; vol. 56; 6; (2015); p. 1124 – 1129; Zh. Strukt. Kim.; vol. 56; 6; (2015); p. 1177 – 1182,6;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 75415-03-1, These common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, copper hexahydrate perchlorate [Cu [C104] 2 · 6H20] (167 mg,0.45 mmol) and excess copper powder (230 mg, 3.62 mmol) were stirred in 8 mL of acetonitrile for 20 minutes,After which a solution of 1,4-bis [diphenylphosphine] butane (384 mg, 0.90 mmol) in 12 mL of dichloromethane was added,After stirring for 1 hour, a solution of 3- [2-pyridyl] pyrazole ligand (131 mg, 0.90 mmol) was added,The reaction was continued for 3 hours at room temperature. After filtration, the solvent was evaporated to dryness on a rotary evaporator,And recrystallized from a mixed solvent of dichloromethane (2 mL) and diethyl ether (20 mL) at a volume ratio of 1:10.Filtered and recrystallized to give colorless crystalline product which was washed 3-4 times with 25 mL of diethyl ether,After drying in vacuo, a white solid product was obtained as perchlorate ? bis [3- [2-Pyridyl] pyrazole] bis [mu-Mu-bis [diphenylphosphine] butane] bis [copper (II) complex] (456 mg, 0.31 mmol)was 69%.

The synthetic route of 75415-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangxi University of Science and Technology; Chen, Jinglin; Guo, Zonghao; He, lihua; Liu, Suijun; Wen, Herui; (13 pag.)CN104877673; (2016); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 75415-03-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Compound 4a (2 mmol), NaH (2.4 mmol) and indole were dissolved in DMF (10 mL). The reaction mixture was stirred at room temperature for 12h before diluted with water (20 mL) and extracted with ethyl acetate (30 mL × 3). The organic layer was concentrated in vacuum. Purication by ash column chromatography gave the target product 5h.

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Pyrazol-3-yl)pyridine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Chen-Ru; Wang, Ze-Feng; Shi, Lu; Wang, Zhong-Chang; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2382 – 2390;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 75415-03-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 16 Synthesis of 2-(1-(2-fluoro-4-nitrophenyl)-3-pyrazolyl)pyridine (18a) Compound 17a (1 g, 6.9 mmol) obtained from the aforesaid process and 3,4-difluoronitrobenzene (0.74 mL) were dissolved in N,N-dimethylformamide (20 mL), and then anhydrous potassium carbonate (1.9 g) was added thereto. The mixture was reacted at 100 C for 4 hours. After completion of the reaction, the reactant mixture was cooled to room temperature. Water was added to the mixture, resulting in a substantial amount of precipitate. Then, the precipitate wassuction-filtered, and the filter cake was recrystallized with acetone to get the product 18a as a white powder (1.7 g), witha yield of 93.4%.[0110] 1H-NMR (400 MHz, CDCl3 ): delta 8.69-8.70 (m, 1H), 8.39-8.44 (m, 1H), 8.26-8.27 (m, 1H), 8.15-8.21 (m, 2H),8.11-8.13 (m, 1H), 7.78-7.82 (m, 1H), 7.30-7.32 (m, 1H), 7.22 (d, J= 2.4 Hz, 1H)

The synthetic route of 2-(1H-Pyrazol-3-yl)pyridine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD.; Si Chuan University; LUO, Youfu; WANG, Zhenling; WEI, Yuquan; GENG, Funeng; EP2738169; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 75415-03-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Compound 4a (2 mmol), NaH (2.4 mmol) and indole were dissolved in DMF (10 mL). The reaction mixture was stirred at room temperature for 12h before diluted with water (20 mL) and extracted with ethyl acetate (30 mL × 3). The organic layer was concentrated in vacuum. Purication by ash column chromatography gave the target product 5h.

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Pyrazol-3-yl)pyridine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Chen-Ru; Wang, Ze-Feng; Shi, Lu; Wang, Zhong-Chang; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2382 – 2390;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 75415-03-1,Some common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, molecular formula is C8H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-(1H-pyrazole-3-yl)pyridine (3.02 g, 20.80 mmol) and NBS (3.72 g, 20.90 mmol) in DMF (30 mL) was stirred for 2 h in an ice bath. The reaction mixture was poured into ice water, filtered, and dried in vacuo. The residue (4.38 g, 95% yield) as a white solid was reacted without further purification. 1H-NMR (270 MHz, CDCl3) delta: 11.46 (1H, br s), 8.63-8.65 (1H, m), 8.29 (1H, d, J = 8.4 Hz), 7.78-7.85 (1H, m), 7.64 (1H, s), 7.28-7.33 (1H, m). LC/MS (ESI): m/z 223 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Pyrazol-3-yl)pyridine, its application will become more common.

Reference:
Article; Sekimata, Katsuhiko; Sato, Tomohiro; Sakai, Naoki; Watanabe, Hisami; Mishima-Tsumagari, Chiemi; Taguri, Tomonori; Matsumoto, Takehisa; Fujii, Yoshifumi; Handa, Noriko; Honma, Teruki; Tanaka, Akiko; Shirouzu, Mikako; Yokoyama, Shigeyuki; Miyazono, Kohei; Hashizume, Yoshinobu; Koyama, Hiroo; Chemical and Pharmaceutical Bulletin; vol. 67; 3; (2019); p. 224 – 235;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 75415-03-1, A common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, molecular formula is C8H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-(2-pyridyl)pyrazole (291 mg, 2 mmol) in THF (20 mL) was added NaH (0.3 g, 12.5 mmol). The mixture was stirred for lh and the Mel (568 mg, 4 mmol) was added in one portion. The reaction mixture was stirred for 18h at room temperature. The reaction was quenched with MeOH and the solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic phase was dried over Na2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 3-(2-pyridyl)-l-methylpyrazole (300 mg, 94%) as a yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.