Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, A new synthetic method of this compound is introduced below., name: 2-(1H-Pyrazol-3-yl)pyridine
EXAMPLE 12 The synthesis of 1,3-di(2-pyridyl)pyrazole (13). A mixture of compound 11 (22.2 g, 153 mmol) and 2-bromopyridine (42.3 g, 268 mmol) was heated for 20 h at 190 C. The cooled mixture was dissolved in hot H2 O (200 ml) and the pH was adjusted to basic with solid Na2 CO3. After cooling, the precipitate was filtered and washed with cold H2 O. Yield: 32.9 g (97%). UV (EtOH): 294, 283, 224. IR (KBr): 1593, 1578 (arom). 1 H-NMR (CDCl3): 7.14 (d, J=2.6, 1H); 7.21 (ddd, J=1.0, 4.9, 7.3, 1H); 7.27 (ddd, J=1.1, 4.9, 7.3, 1H); 7.79 (dt, J=1.7, 7.3, 1H); 7.85 (dt, J=1.7, 7.3, 1H); 8.12-8.16 (m, 2H); 8.44 (dd, J=1.7, 4.9, 1H); 8.64 (d, J=2.6, 1H); 8.68 (bd, J=4.9, 1H).
The synthetic route of 75415-03-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wallac Oy; US5859215; (1999); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics