Synthetic Route of 75415-03-1, These common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under an argon atmosphere, copper hexahydrate perchlorate [Cu [C104] 2 · 6H20] (167 mg,0.45 mmol) and excess copper powder (230 mg, 3.62 mmol) were stirred in 8 mL of acetonitrile for 20 minutes,After which a solution of 1,4-bis [diphenylphosphine] butane (384 mg, 0.90 mmol) in 12 mL of dichloromethane was added,After stirring for 1 hour, a solution of 3- [2-pyridyl] pyrazole ligand (131 mg, 0.90 mmol) was added,The reaction was continued for 3 hours at room temperature. After filtration, the solvent was evaporated to dryness on a rotary evaporator,And recrystallized from a mixed solvent of dichloromethane (2 mL) and diethyl ether (20 mL) at a volume ratio of 1:10.Filtered and recrystallized to give colorless crystalline product which was washed 3-4 times with 25 mL of diethyl ether,After drying in vacuo, a white solid product was obtained as perchlorate ? bis [3- [2-Pyridyl] pyrazole] bis [mu-Mu-bis [diphenylphosphine] butane] bis [copper (II) complex] (456 mg, 0.31 mmol)was 69%.
The synthetic route of 75415-03-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangxi University of Science and Technology; Chen, Jinglin; Guo, Zonghao; He, lihua; Liu, Suijun; Wen, Herui; (13 pag.)CN104877673; (2016); B;,
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