Category: 288148-34-5

Reference of 288148-34-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 1mL of a solution containing arylsulfonyl chloride or arylacyl chloride or arylisocyanates ([Diversity reagent 13{1-8},13{9-10} or 13{11-12}, 0.40 mmol, 5 equiv) in CH2Cl2was added to the resin followed by addition of DIEA (0.88 mmol, 11 eq). Thereactors were shaken for 2 h at room temperature. The resin was drained andwashed with DMF (3 x 5 mL), MeOH (1 x 5 mL), and CH2Cl2(3 x 5 mL), and dried under low vacuum. The procedure described abovewas repeated.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazole-4-sulfonyl chloride. I believe this compound will play a more active role in future production and life.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa; Partyka, Anna; Sataa, Grzegorz; Ledna, Tomasz; Jastrzebska-Wiesek, Magdalena; Wesoowska, Anna; Bojarski, Andrzej J.; Zajdel, Pawel; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 334 – 346;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride

Add triethylamine (3.403 mL, 24.414 mmol) to a stirring solution of {2-[4-(2- chloro-pyridin-3-yl)-piperazin-l-yl]-ethyl}-methyl-amine hydrochloride salt (2.000 g, 6.103 mmol) in dichloromethane (100 mL). Add 1 -methyl- lH-pyrazole-4-sulfonyl chloride (1.102 g, 6.103 mmol) at room temperature. Stir at room temperature for 30 min. Dilute with dichloromethane and saturated aqueous sodium bicarbonate. Separate phases and extract the aqueous phase with dichloromethane. Combine the organic phases, dry over sodium sulfate, filter, and concentrate. Purify the resulting material by silica gel chromatography eluting with hexanes: acetone 1 : 1 to afford the title preparation (1.600 g, 66% yield). MS ES: m/z = 399 [M+H]+.

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2009/29439; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 288148-34-5

te/f-Butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carb- amate (35 mg, 0.082 mmol) was dissolved in dichloromethane (0.8 mL). 4-Dimethylamino- pyridine (10 mg, 0.082 mmol) and 1-methyl-1 H-pyrazole-4-sulfonyl chloride (16 mg, 0.09 mmol) was added. The reaction mixture was stirred at room temperature over night. The reaction mixture was diluted with ethyl acetate (20 ml) and washed with aqueous hydrochloric acid (1 N, 5 ml, twice) and sodium bicarbonate. The organic layer was dried (magnesium sulfate) and concentrated in vacuo. The crude product was purified by preparative thin layer chromatography (silica, ethyl acetate, n-heptane). Yield: 36 mg(0.063 mmol, 77%)ESI-MS [M-C02-isobutene+H+] = 473 Calculated for C29H37CIN4O4S = 572

The synthetic route of 1-Methyl-1H-pyrazole-4-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT GMBH & CO. KG; ABBOTT LABORATORIES; AMBERG, Wilhelm; OCHSE, Michael; LANGE, Udo; BEHL, Berthold; HORNBERGER, Wilfried; MEZLER, Mario; POHLKI, Frauke; TURNER, Sean; HUTCHINS, Charles; WO2012/20130; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H5ClN2O2S

General procedure: To a solution of methyl 2-amino-4-fluorobenzoate (1.64 g, 9.71 mmol) and methanesulfonyl chloride (5.28 mL, 115 mmol) in dichloromethane (100 mL) was added pyridine (7.86 mL, 97.1 mmol). The solution was stirred at room temperature for 18 hours. The reaction was quenched with 1N HCl and was stirred for 5 minutes. The mixture was extracted with DCM (3×). The combined organic layers were washed with brine, dried over anhydrous MgSO4, filtered and concentrated. The crude product was purified by silica gel chromatography to afford methyl 4-fluoro-2-(methylsulfonamido)benzoate.

The synthetic route of 1-Methyl-1H-pyrazole-4-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

Electric Literature of 288148-34-5,Some common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

100 mg (0.25 mmol) of 2-(4-benzyl-3-(ethoxycarbonylamino)chroman-6- yloxy)ethanaminium chloride were dissolved in 5 ml methylene dichloride. Then, 95 mg (0.79 mmol) dimethyl aminopyridine and 54 mg (0.30 mmol) 1 -methyl-1 H-pyrazole-4- sulfonyl chloride were added. The reaction mixture was stirred at room temperature over night. The mixture was concentrated in vacuo and the residue was dissolved in ethylace- tate and water. The phases were separated. The organic phase was washed with saturated ammonium chloride solution (2x), dried over MgS04 and concentrated (127 mg crude). The crude material was purified by column chromatography to give 1 18 mg (0.23 mmol, 93 %) of the desired product.ESI-MS [M+H+] = 515 Calculated for C25H3oN406S = 514.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its application will become more common.

Electric Literature of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 1-Methyl-1H-pyrazole-4-sulfonic acid 4-[2-(4-bromo-benzyl)-4,5-dimethyl-thiophene-3-carbonyl]-2-cyclopentyl-phenyl ester At ambient temperature, to a stirred solution of [2-(4-bromobenzyl)-4,5-dimethyl-thiophen-3-yl]-(3-cyclopentyl-4-hydroxy-phenyl)-methanone (0.283 g, 0.603 mmol) in N,N-DMF (3.0 mL) was added 60% sodium hydride/mineral oil (24.1 mg, 0.603 mmol). After 0.5 h, to the reaction was added a solution of 1-methyl-1H-pyrazole-4-sulfonyl chloride (0.120 g, 0.664 mmol) in N,N-DMF (1.3 mL). After 3 h, the reaction was quenched with 1N NaOH (40 mL), extracted with CH2 Cl2, dried (Na2 SO4) and concentrated. Purification on Biotage KP-Sil eluding with 20% acetone/hexane gave 0.202 g (55%) of the title compound as a yellow solid, mp 55-60 C. (DMSO-d6) delta 1.29-1.34 (m, 2 H), 1.59-1.79 (m, 6 H), 1.81 (s, 3 H), 2.28 (s, 3 H), 3.08 (quintet, 1 H), 3.87 (s, 2 H), 3.89 (s, 3 H), 6.98 (d, 2 H), 7.32 (d, 1 H), 7.39 (d, 2 H), 7.53-7.57 (m, 2 H), 7.97 (s, 1 H), 8.62 (s, 1 H). IR (KBr) 3450, 2950, 1650, 1490, 1400, 1370 and 1170 cm-1. mass spectrum (+ESI) m/z 613/615 (M+H).

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: pyrazoles-derivatives

Dissolve [2-(3′-chloro-2,3,5,6-tetrahydro-[l,2′]bipyrazinyl-4-yl)-ethyl]-methyl- amine hydrochloride salt (1.0 g, 2.57 mmol) in dichloromethane (20 ml) and cool in an ice-bath. Add triethylamine (1.79 ml, 12.87 mmol) and then 1 -methyl pyrazole-4- sulfonyl chloride (465 mg, 2.57 mmol). Remove the ice-bath and allow to warm to ambient temperature and allow to stir for 20 hr. Wash the combined organic layers with aqueous sodium bicarbonate, brine and water. Dry over sodium sulfate and concentrate. Purify by chromatography, eluting with 1:2 hexanes: acetone to afford the title compound (1.1 g, 97 % yield) as a white foam. MS ES: m/z = 400 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288148-34-5, its application will become more common.

Reference of 288148-34-5, The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Allylamine (1.05 equiv) and triethylamine (1.1 equiv) were added in CH2Cl2 to a solution of sulfonyl chloride (1 equiv) in CH2Cl2 (2.5mL/mmol). The reaction was stirred at room temperature for 1 h, then washedwith sat. NH4Cl solution and brine. The organic phase was dried over MgSO4, filtered and concentrated to give the following sulfonylchlorides, which were used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 288148-34-5

General procedure: 1mL of a solution containing arylsulfonyl chloride or arylacyl chloride or arylisocyanates ([Diversity reagent 13{1-8},13{9-10} or 13{11-12}, 0.40 mmol, 5 equiv) in CH2Cl2was added to the resin followed by addition of DIEA (0.88 mmol, 11 eq). Thereactors were shaken for 2 h at room temperature. The resin was drained andwashed with DMF (3 x 5 mL), MeOH (1 x 5 mL), and CH2Cl2(3 x 5 mL), and dried under low vacuum. The procedure described abovewas repeated.

According to the analysis of related databases, 288148-34-5, the application of this compound in the production field has become more and more popular.

The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 288148-34-5

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.18 1-Methyl-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}-N-cyclopropylmethyl-1H-pyrazole-4-sulfonamide (33) Yellow oil, 70 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 100%, tR = 5.37, C27H34N4O3S, MW 494.65, Monoisotopic Mass 494.24, [M+H]+ 495.4 1H NMR (300 MHz, CDCl3) delta 0.25-0.31 (m, 2H), 0.47-0.55 (m, 2H), 1.52-1.58 (m, 2H), 2.32-2.59 (m, 4H), 3.00 (d, J = 6.73 Hz, 2H), 3.22-3.37 (m, 4H), 3.66-3.76 (m, 2H), 3.92 (s, 3H), 4.37-4.41 (m, 2H), 6.93 (d, J = 8.17 Hz, 1H), 7.02 -7.09 (m, 1H), 7.22-7.38 (m, 7H), 7.65 (s, 1H), 7.78 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 5.16, 12.14, 27.56, 39.52, 48.23, 52.22, 52.73, 52.76, 52.79, 55.72, 63.25, 112.65, 122.28, 123.23, 127.20, 128.00, 128.99, 129.55, 130.81, 131.41, 131.59, 137.84, 138.35, 154.12. Anal. calcd for C27H34N4O3S¡¤2HCl: C, 57.14; H, 6.39; N, 9.87; S, 5.65; Found: C, 56.94; H, 6.69′ N, 10.12; S, 5.36. Mp for C27H34N4O3S¡¤2HCl: 198.3-198.8 C.

The chemical industry reduces the impact on the environment during synthesis 288148-34-5. I believe this compound will play a more active role in future production and life.