Category: 92-43-3

Related Products of 92-43-3,Some common heterocyclic compound, 92-43-3, name is 1-Phenyl-3-pyrazolidinone, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of CH2Cl2 (10 mL), H2SO4 (0.01 mol), intermediates 2 (0.01 mol) and KI (0.01 mol) was stirred at room temperature. Then, 30% H2O2 (0.02 mol) was added dropwise. The mixture was stirred at room temperature for 2 h and the product 3 directly crystallised from the CH2Cl2. Then 5% NaHSO3 (5 mL) was added to the mixture. The suspension was filtered off and washed, and the products were purifiedby recrystallisation from methanol.

The synthetic route of 92-43-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Jingjing; Yang, Shanguang; Dong, Ruimei; Jin, Zhudan; Wang, Mingliang; Journal of Chemical Research; vol. 42; 1; (2018); p. 24 – 27;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 92-43-3, name is 1-Phenyl-3-pyrazolidinone, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92-43-3, Computed Properties of C9H10N2O

1-Phenylpyrrolidin-3-one (82.99mmoM.0eq)Dissolved with 5% aqueous sodium hydroxide solution,Add ferric chloride hexahydrate (16.60 mmol, 0.2 eq), and pass the system to oxygen and keep the temperature at 80 C. After the reaction is completed, add water to the reaction solution to quench the reaction, and adjust RhoEta=1~2 with hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate.Concentrated under reduced pressure, and the residue was purified by column chromatography (eluent: PE: EpsilonAlpha = 2:1)The pale yellow solid product 1-phenyl-1H-pyrazol-3-ol (1.46 g, yield 11%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenyl-3-pyrazolidinone, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Taihe International Trade Co., Ltd.; Du Yonglei; Lv Liang; Li Hongwei; Liu Shiqin; Liu Jiyong; Hou Shuang; Ma Wen; (36 pag.)CN108503587; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 92-43-3, name is 1-Phenyl-3-pyrazolidinone, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92-43-3, Quality Control of 1-Phenyl-3-pyrazolidinone

EXAMPLE 2 alpha-Hydroxy-5-oxo-2-phenyl-1-pyrazolidine acetic acid By following the procedure of Example 1 and substituting 1-phenyl-3-pyrazolidinone for 1-[4-(trifluoromethyl)phenyl]-3-pyrazolinone the title compound is obtained in 48% yield, with a melting point of 127-9 C. Analysis for: C11 H12 N2 O4. Calcuated: C, 55.92; H, 5.12; N, 11.86. Found: C, 56.22; H, 5.37; N, 11.76.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 92-43-3, A common heterocyclic compound, 92-43-3, name is 1-Phenyl-3-pyrazolidinone, molecular formula is C9H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-Phenylpyrrolidin-3-one (82.99mmoM.0eq)Dissolved with 5% aqueous sodium hydroxide solution,Add ferric chloride hexahydrate (16.60 mmol, 0.2 eq), and pass the system to oxygen and keep the temperature at 80 C. After the reaction is completed, add water to the reaction solution to quench the reaction, and adjust RhoEta=1~2 with hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate.Concentrated under reduced pressure, and the residue was purified by column chromatography (eluent: PE: EpsilonAlpha = 2:1)The pale yellow solid product 1-phenyl-1H-pyrazol-3-ol (1.46 g, yield 11%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 92-43-3, name is 1-Phenyl-3-pyrazolidinone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 92-43-3

(a) 3-Chloro-4,5-dihydro-1-phenyl-1H-pyrazole 1-Phenylpyrazolidin-3-one (8.1 g) was suspened in dry toluene (100 ml), followed by addition of phosphoryl chloride (7.0 ml) and the mixture stirred for 1 hour at 85. When cool the toluene was decanted from the solid and solvent removed in vacuo to give the sub-title compound, (6.9 g), mp 92-93.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92-43-3.

These common heterocyclic compound, 92-43-3, name is 1-Phenyl-3-pyrazolidinone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 92-43-3

(a) 3-Chloro-4,5-dihydro-1-phenyl-1H-pyrazole 1-Phenylpyrazolidin-3-one (8.1 g) was suspened in dry toluene (100 ml), followed by addition of phosphoryl chloride (7.0 ml) and the mixture stirred for 1 hour at 85. When cool the toluene was decanted from the solid and solvent removed in vacuo to give the sub-title compound, (6.9 g), mp 92-93.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92-43-3.