Category: 15366-34-4

Reference of Methyl 1H-pyrazole-3-carboxylateIn 1992 ,《Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides》 appeared in Journal of Medicinal Chemistry. The author of the article were Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; Marongiu, Maria E.; Pani, Alessandra; La Colla, Paolo; Tramontano, Enzo. The article conveys some information:

Several pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-oneribonucleosides, e.g. I (R = R1 = H; R = R1 = H, Me, R = Br, iodo, R1 = H) and II (R2 = Me, CMe3, CH2Ph), were prepared and tested for antiviral/antitumor activities. Appropriate heterocyclic bases were prepared by standard methodologies. All compounds were evaluated in vitro for cytostatic and antiviral activity. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Reference of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Reference of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1977,Gilman, Norman W.; Holland, Betty C.; Walsh, Gregory R.; Fryer, R. Ian published 《Nucleophilic displacement of aromatic fluorine. Part V. Use of nitrogen heterocycles as nucleophiles》.Journal of Heterocyclic Chemistry published the findings.Recommanded Product: 15366-34-4 The information in the text is summarized as follows:

I (R = F) reacted with imidazole, 2-methylimidazole, 3,5-bis(acetoxymethyl)pyrazole, pyrrole, di-Et 2-methyl-4,5-imidazoledicarboxylate, Me pyrrole-2-carboxylate, di-Me pyrazole-3,5-dicarboxylate, and Me pyrazole-3-carboxylate to give N-aryl heterocycles, e.g., II. In some cases the analogous reaction with I (R = Cl) failed to occur. Some substitution reactions of other aromatic fluorides were also examined The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Recommanded Product: 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Recommanded Product: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Safety of Methyl 1H-pyrazole-3-carboxylateIn 2011 ,《Esterification of pyrazole-3- and 4-carboxylic acids》 appeared in Russian Journal of General Chemistry. The author of the article were Saakyan, A. A.. The article conveys some information:

The esterification of pyrazole-3- and 4-carboxylic acids with MeOH was described.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Safety of Methyl 1H-pyrazole-3-carboxylate) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Yu, Haibo; Cheng, Yan; Xu, Man; Song, Yuquan; Luo, Yanmei; Li, Bin published 《Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives》.Journal of Agricultural and Food Chemistry published the findings.Reference of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

A series of novel pyrazolyl acrylonitrile derivatives were designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of 1H NMR, 13C NMR and MS spectra. The structures of compounds (I) and (II) were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound II exhibits excellent acaricidal activity against all developmental stages of Tetranychus cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds II to mammals is quite low. The structure-activity relationships are also discussed. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Reference of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Reference of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C5H6N2O2In 1976 ,《Unusual reaction of 3-carbomethoxy-Δ2-pyrazoline in the presence of lead tetraacetate》 appeared in Khimiya Geterotsiklicheskikh Soedinenii. The author of the article were Akhrem, A. A.; Kvasyuk, E. I.; Mikhailopulo, I. A.. The article conveys some information:

Treatment of pyrazolinecarboxylate I with Pb(OAc)4 in dry C6H6 30 min at 70° gave 71% II and 14% III whose structures were confirmed by ir, uv, and NMR spectra. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: Methyl 1H-pyrazole-3-carboxylateIn 2021 ,《Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction》 was published in Organic Process Research & Development. The article was written by Burns, Matthew; Perkins, Dave; Chan, Lai C.; Pilling, Michael J.; Jawor-Baczynska, Anna; Mullen, Alexander K.; Steven, Alan; Wimsey, Chris; Elmekawy, Ahmed; Lamacraft, Alex; Dobson, Benjamin C.; McMillan, Angus E.; Hose, David R. J.; Inglesby, Phillip A.; Raw, Steven A.; Jones, Martin F.. The article contains the following contents:

Route design and process development of the small nitrogen heterocycle I, a constituent of AZD5718 (II), is described. The novel synthetic sequence to I involves a desymmetrizing alkylation of 4-nitropyrazole, a non-cryogenic lithiation-alkoxycarbonylation, and a global reduction-cyclization. This new synthetic route was implemented in the manufacture of I and was able to deliver over 1000 kg of product with a yield of 77% over the three stages. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Name: Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1988,Bulychev, Yu. N.; Preobrazhenskaya, M. N.; Chernyshev, A. I.; Esipov, S. E. published 《N-Alkylation of substituted pyrazoles and pyrazolo[3,4-d]pyrimidines by dimethylformamide diethyl acetal or orthoformate》.Khimiya Geterotsiklicheskikh Soedinenii published the findings.SDS of cas: 15366-34-4 The information in the text is summarized as follows:

Alkylating pyrazolecarboxylate I (R = R1 = H) by DMF di-Et acetal or HC(OEt)3 gives mixtures containing 41 and 38% I (R = Et, R1 = H) and 36 and 23% I (R = H, R1 = Et), resp. Similarly, alkylation of pyrazolopyrimidine II (R2 = MeS, R3 = H) gave 60 and 43% III, resp. Addnl. obtained were III (R2 = R3 = MeS, EtS; R2 = EtO, MeS). The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4SDS of cas: 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.SDS of cas: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1988,Tserunyan, V. V.; Asratyan, G. V.; Darbinyan, E. G. published 《Intramolecular hydrogen bond in 1-vinyl-5-pyrazolecarboxylic acid esters》.Khimiya Geterotsiklicheskikh Soedinenii published the findings.Computed Properties of C5H6N2O2 The information in the text is summarized as follows:

Pyrazolecarboxylates I (R = Me, Et, CHMe2, Bu; R1 = H) reacted with vinyl acetate in the presence of Hg(OAc)2 to give I (same R; R1 = vinyl) and their isomers (II). Intramol. H bonding between the α proton of the vinyl group and the carbonyl O was detected in II by NMR. After reading the article, we found that the author used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: Methyl 1H-pyrazole-3-carboxylateIn 1991 ,《Effect of electron-withdrawing groups on the thermal ring opening of 3H-pyrazoles to diazoalkenes》 was published in Journal of Chemical Research, Synopses. The article was written by Nakano, Yoshihiko; Hamaguchi, Masashi; Nagai, Toshikazu. The article contains the following contents:

3-Cyano-3H-pyrazoles, bearing a cyano, a p-chlorophenyl, or a p-chlorobenzyl group at C-3, e.g. I, generated from elimination reaction of the corresponding dihydropyrazoles with a leaving group such as a chlorine or p-chlorobenzoyloxy group, gave diazoalkene derivatives, resulting from the ring-opening of the 3H-pyrazoles. 3-Methoxycarbonyl-3H-pyrazoles bearing a methoxycarbonyl, a p-chlorophenyl, or p-chlorobenzyl group at C-3, prepared in a similar manner, gave mainly 1-methoxycarbonyl-1H-pyrazole derivatives, resulting from migration of the 3-methoxycarbonyl group to the adjacent nitrogen within the generated 3H-pyrazoles. Treatment of 3H-pyrazoles and 5-substituted 1-methoxycarbonyl-1H-pyrazoles with triethylamine gave 3-substituted 1-methoxycarbonyl-1H-pyrazoles, resulting from migration of the methoxycarbonyl group to the remote nitrogen. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Recommanded Product: Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Functionalized pyrazole with 1,3-alternate calix[4]arene and triazole ligands as highly selective fluorescent sensor for Hg2+ and Ag+ ions》 was written by Chen, Yin-Ju; Chen, Meng-Yu; Lee, Kun-Ti; Shen, Li-Ching; Hung, Hao-Chih; Niu, Hao-Che; Chung, Wen-Sheng. Application of 15366-34-4 And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020. The article conveys some information:

We report here the synthesis of a 1,3-alternate calix[4]arene 8, with bis-pyrazolylmethylpyrenes on the one end and bis-triazolylmethylphenyls on the other end, as a homoditropic fluorescent sensor for both Hg2+ and Ag+ ions. Calix[4]arene 3, with lower-rim bis-pyrazolylmethylpyrenes in cone conformation, was also synthesized as a control compound UV-Vis and fluorescence spectra were used for metal ions screening, and we found that both ligands 8 and 3 showed strong excimer emission of pyrenes when they are as a free ligand in CHCl3/MeOH (volume/volume, 3:1) solution; however, they both showed a high selectivity toward Hg2+ and Ag+ ions with strong fluorescence quenching and yet with different binding ratios. The fluorescence of ligand 8 was strongly quenched by Hg2+ but was only partially quenched by Ag+ ions; however, the fluorescence of ligand 3 was strongly quenched by Hg2+, Ag+, and Cu2+ ions. Job plot experiments showed that ligand 8 formed a 1:2 complex with both Hg2+ and Ag+ ions; ligand 3 formed a 1:1 complex with Hg2+, but it formed a 2:3 complex with Ag+. The binding constant of ligand 3 with Hg2+ and Ag+ ions was determined by the Benesi-Hildebrand plot of UV-vis titration experiments to be 2.99 x 103 and 3.83 x 103 M-1, resp., while the association constant of ligand 8 with Hg2+ and Ag+ was determined by Hill plot to be 1.46 x 1012 and 9.24 x 1011 M-2, resp. Ligand 8 forms a strong complex with either two Hg2+ or two Ag+ ions using both the upper and lower rims of the 1,3-alternate calix[4]arene as the binding pockets; hence, it represents one of the highly selective fluorescent sensors for the homoditropic sensing of Hg2+ and Ag+ ions. After reading the article, we found that the author used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics