Category: 10250-64-3

Electric Literature of 10250-64-3, A common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

The synthetic route of 10250-64-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nakagawa, Hidehiko; Seike, Suguru; Sugimoto, Masatoshi; Ieda, Naoya; Kawaguchi, Mitsuyasu; Suzuki, Takayoshi; Miyata, Naoki; Bioorganic and Medicinal Chemistry Letters; vol. 25; 23; (2015); p. 5619 – 5624;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 10250-64-3,Some common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3, Recommanded Product: 10250-64-3

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 10250-64-3,Some common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2. 1 -Methyl-3 -phenyl-N- [( 1 -pyridin-3 -ylcyclohexyl)methyl] – 1 H-pyrazole-5 – carboxamide; A solution of DMC in DCM (1.2 mL, 0.1 M, 1.2 eq.) is added to a solution of 2- methyl-5-phenyl-2H-pyrazole-3-carboxylic acid (20 mg, 0.1 mmol, 1.0 equ.), (1 -pyridin-3 -yl- cyclohexyl)-methylamine (19 mg, 0.1 mmol, 1.0 eq.) and TEA (33 muL, 0.24 mmol, 2. 4 eq.) in DCM (1.0 mL) at RT. After standing overnight at RT, the reaction mixture is purified by PTLC (EtOAc/etaexanes/TEA 50/50/1) to give the title compound. LC/MS (M+l) = 375.16; RT = 1.38 min. *IC50.

The synthetic route of 10250-64-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 10250-64-3, These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: Synthesis of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide, 1-90 [00355] Methanesulfonyl chloride (0.04 ml, 0.52 mmol) was added to a stirred mixture of 4- amino-N-(4-methoxy-6-methylpyrimidin-2-yl)benzene-l -sulfonamide (19.2, 110 mg, 0.37 mmol), l-methyl-3 -phenyl- lH-pyrazole-5-carboxylic acid (76mg, 0.37 mmol) and 3-picoline (0.11 ml, 1.12 mmol) in MeCN (dry, 5ml) at 0C. After addition the reaction mixture was allowed to reach rt and stirred for lh. The reaction crude was partitioned between DCM (75ml) and water (50ml). The aqueous layer was further extracted with DCM (2x 50ml) and the combined layers were evaporated to afford a material which was purified by prep HPLC (MeCN /Water, 0.1% formic acid) to obtain 126 mg (68%) of N-{4-[(4-methoxy-6-methylpyrimidin-2- yl)sulfamoyl]phenyl}-l-methyl-3-phenyl-lH-pyrazole-5-carboxamide 1-90 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 12.77 (s, 1H), 10.53 (s, 1H), 7.87 (s, 4H), 7.81 (d, J = 7.2 Hz, 2H), 7.50 (s, 1H), 7.45 (t, J = 7.7 Hz, 2H), 7.35 (t, J = 7.4 Hz, 1H), 6.14 (s, 1H), 4.14 (s, 3H), 3.73 (s, 3H), 2.21 (s, 3H).

Statistics shows that 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 10250-64-3.

These common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 10250-64-3

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

The synthetic route of 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3, Recommanded Product: 10250-64-3

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

10250-64-3, Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3.

A mixture of HATU (0.5593 g, 1.471 mmol), DIPEA (0.7066 ml, 4.045 mmol), N- (2-aminoethyl) -4-ethoxybenzamide hydrochloride (0.300 g, 1.226 iranol) and l-methyl-3-phenyl-lH-pyrazole-5- carboxylic acid (0.2479 g, 1.226 mmol) in THF (15 mL) was stirred at room temperature overnight. The mixture was quenched with water (150 ml) and the solid filtered, dried on high vacuum and purified on silica gel by eluting with 75% EtOAc/Hex. The pure material was recrystallized from EtOAc/hexanes to give N- (2- (4-ethoxybenzamido) ethyl) -1-methyl- 3-phenyl-lH-pyrazole-5-carboxamide (0.145 g, 30%) as a white solid: 1H NMR (400 MHz, DMSOd6) delta 1.33 (t, J = 7.0 Hz, 3H), 3.42 (br, 4H), 4.05-4.10 (m, 5H), 6.97 (d, J = 8.8 Hz, 2H), 7.23 (s, IH), 7.32 (t, J = 7.3 Hz, IH), 7.43