According to the analysis of related databases, 10250-64-3, the application of this compound in the production field has become more and more popular.
10250-64-3, Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3.
A mixture of HATU (0.5593 g, 1.471 mmol), DIPEA (0.7066 ml, 4.045 mmol), N- (2-aminoethyl) -4-ethoxybenzamide hydrochloride (0.300 g, 1.226 iranol) and l-methyl-3-phenyl-lH-pyrazole-5- carboxylic acid (0.2479 g, 1.226 mmol) in THF (15 mL) was stirred at room temperature overnight. The mixture was quenched with water (150 ml) and the solid filtered, dried on high vacuum and purified on silica gel by eluting with 75% EtOAc/Hex. The pure material was recrystallized from EtOAc/hexanes to give N- (2- (4-ethoxybenzamido) ethyl) -1-methyl- 3-phenyl-lH-pyrazole-5-carboxamide (0.145 g, 30%) as a white solid: 1H NMR (400 MHz, DMSOd6) delta 1.33 (t, J = 7.0 Hz, 3H), 3.42 (br, 4H), 4.05-4.10 (m, 5H), 6.97 (d, J = 8.8 Hz, 2H), 7.23 (s, IH), 7.32 (t, J = 7.3 Hz, IH), 7.43